2010 Fiscal Year Final Research Report
Development of effectiveness of chemoradiotherapy for advanced esophageal cancer
| Project/Area Number |
20591570
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Tottori University |
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Principal Investigator |
IKEGUCHI Masahide Tottori University, 医学部, 教授 (20193188)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 食道癌 / 放射線化学療法 / NFκB siRNA |
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| Research Abstract |
Chemotherapy is the key of treatment of advanced esophageal squamous cell carcinoma (ESCC). Immunohistchemistry of 109 patients with ESCC revealed that NF-κB expressed in the nuclei of 60% of tumors and correlated with tumor progression. The effect of 5-FU was evaluated on the proliferation of two ESCC cell lines (TE-4 and TE-8). When cultured cells were exposed to TNFa, NF-κB translocated to the nucleus and was activated. Cells with activated NF-κB had poor sensitivity to 5-FU. After transfection with NF-κB siRNA into the cells, the level of NF-κB protein was decreased and the sensitivity against to 5-FU of cell was recovered. These results suggest that NF-κB may be a target for ESCC therapy because of its selective expression in this type of cancer.
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