2010 Fiscal Year Final Research Report
The effect of i nterleukin-17 producing CD4+ T cells (T_H-17 cells) on immune system and progression of digestive cancer.
| Project/Area Number |
20591571
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Tottori University |
|---|
Principal Investigator |
SAITO Hiroaki Tottori University, 医学部, 助教 (20335532)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | 消化器癌 / T_H-17細胞 / インターロイキン17 |
|---|
| Research Abstract |
In the current study, we determined the frequency of T_H-17 cells obtained from gastric cancer patients. In addition, clinical significance of IL-17 that is mainly produced by T_H-17 cells was determined in gastric cancer patients. The frequency of T_H-17 cells in the tissue of gastric cancer was significantly more than those in peripheral blood. The concentration of IL-17, hallmark of T_H-17, in gastric cancer patients was significantly higher than that in normal controls. The prognosis of gastric cancer patients with high IL-17 concentration was significantly poor than that with low IL-17 concentration. Furthermore, multivariate analysis indicated that IL-17 concentration was an independent prognostic indicator as well as lymph node metastasis was. In conclusion, T_H-17 cells may play an extremely important role in the progression of gastric cancer though the IL-17 production.
|
