2010 Fiscal Year Final Research Report
Clinical significance of Laminin-332 and its potential as a therapeutic target
| Project/Area Number |
20591572
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
MIYANARI Nobutomo Kumamoto University, 医学部附属病院, 非常勤診療講師 (90336230)
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| Co-Investigator(Kenkyū-buntansha) |
HAYASHI Naoko 熊本大学, 医学部附属病院, 非常勤診療医師 (20452899)
BABA Hideo 熊本大学, 大学院・生命科学研究部, 教授 (20240905)
YOSHIDA Naoya 熊本大学, 医学部附属病院, 非常勤診療医師 (60467983)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 食道外科学 / mTOR / RAD001 / ラミミン-332 |
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| Research Abstract |
Inactivation of the AKT pathway by laminin-332 blocking antibody suppressed the invasiveness of esophageal cancer cell line. The addition of the purified laminin-332 activated the AKT pathway and increased the invasiveness of cell line. These results indicate that Laminin-332 could contribute to the malignant behavior of esophageal cancer through AKT pathway. mTOR is a key molecule in the AKT pathway and is increasingly important as a potential target for anticancer therapy. Thus, we focused on revealing clinical usefulness of mTOR inhibitor in esophageal cancer. p-mTOR overexpression was independently associated with poor prognosis in ESCC, supporting the potential for mTOR as a therapeutic target for ESCC. We are currently performing further in vitro and in vivo study to clarify the antitumor effect of RAD001 (mTOR inhibitor) on ESCC.
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[Journal Article] Clinical Significance of Wntinduced Secreted Protein-1 (WISP -1/CCN4) in Esophageal Squamous Cell Carcinoma.2011
Author(s)
Nagai Y, Watanabe M, Ishikawa S, Karashima R, Kurashige J, Iwagami S, Iwatsuki M, Baba Y, Imamura Y, Hayashi N, Baba H.
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Journal Title
Anticancer Res. 31(3)
Pages: 991-997
Peer Reviewed
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[Journal Article] Induction chemotherapy with docetaxel/cisplatin/5-fluorouracil for patients with node-positive esophageal cancer.2011
Author(s)
Watanabe M, Nagai Y, Kinoshita K, Saito S, Kurashige J, Karashima R, Hirashima K, Sato N, Imamura Y, Hiyoshi Y, Baba Y, Iwagami S, Miyamoto Y, Iwatsuki M, Hayashi N, Baba H.
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Journal Title
Digestion. 83(3)
Pages: 146-152
Peer Reviewed
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[Journal Article] Extensive lymphatic spread of cancer cells in patients with thoracic esophageal squamous cell carcinoma : detection of CEA-mRNA in the three-field lymph nodes.2010
Author(s)
Imamura Y, Hayashi N, Sato N, Kinoshita K, Kurashige J, Saito S, Hirashima K, Karashima R, Hiyoshi Y, Nagai Y, Watanabe M, Baba H.
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Journal Title
J Surg Oncol. 102(5)
Pages: 509-515
Peer Reviewed
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[Journal Article] Phosphorylated mTOR expression is associated with poor prognosis for patients with esophageal squamous cell carcinoma.2010
Author(s)
Hirashima K, Baba Y, Watanabe M, Karashima R, Sato N, Imamura Y, Hiyoshi Y, Nagai Y, Hayashi N, Iyama K, Baba H.
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Journal Title
Ann Surg Oncol. 17(9)
Pages: 2486-2493
Peer Reviewed
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[Journal Article] p12CDK2-AP1 is associated with tumor progression and a poor prognosis in esophageal squamous cell carcinoma.2009
Author(s)
Hiyoshi Y, Watanabe M, Hirashima K, Karashima R, Sato N, Imamura Y, Nagai Y, Yoshida N, Toyama E, Hayashi N, Baba H.
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Journal Title
Oncol Rep. 22(1)
Pages: 35-39
Peer Reviewed
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[Journal Article] Transcervical superior mediastinal lymph node dissection combined with transhiatal lower esophageal dissection before transthoracic esophagectomy : a safe approach for salvage esophagectomy.2009
Author(s)
Watanabe M, Yoshida N, Karashima R, Sato N, Hirashima K, Imamura Y, Hiyoshi Y, Nagai Y, Iwagami S, Toyama E, Hayashi N, Baba H.
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Journal Title
J Am Coll Surg. 208(4)
Pages: e7-e9
Peer Reviewed
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[Journal Article] MicroRNA-21 regulates the proliferation and invasion in esophageal squamous cell carcinoma.2009
Author(s)
Hiyoshi Y, Kamohara H, Karashima R, Sato N, Imamura Y, Nagai Y, Yoshida N, Toyama E, Hayashi N, Watanabe M, Baba H.
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Journal Title
Clin Cancer Res. 15(6)
Pages: 1915-1922
Peer Reviewed
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[Journal Article] Multiple and metachronous esophageal intramural metastases from a gastric adenocarcinoma.2008
Author(s)
Ikeda O, Toh Y, Aoki Y, Harimoto N, Taomoto J, Masuda T, Ohga T, Adachi E, Sakaguchi Y, Okamura T, Hirahashi M, Nishiyama K, Baba H.
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Journal Title
Gastric Cancer. 11(2)
Pages: 19-22
Peer Reviewed
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[Presentation] Phosphorylated mTOR activation and therapeutic effects of everolimus (RAD001) in esophageal squamous cell carcinoma.2010
Author(s)
Hirashima K, Baba Y, Watanabe M, Sato N, Karashima R, Kurashige J, Imamura Y, Iwatsuki M, Hayashi N,Iyama K, Baba H.
Organizer
7^<th> International symposium on cancer research and therapy (ISCRT)
Place of Presentation
東京 東京会館
Year and Date
20101126-20101127
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[Presentation] Cerulein induced acute pancreatitis suppress the mTOR activity.2010
Author(s)
Ida S, Ohmuraya M, Hirota M, Nakahara O, Furuhashi S, Abe S, Tanaka H, Horino K, Takamori H, Beppu T, Baba H.
Organizer
Joint Meeting of the International Association of Pancreatology and the Japan Pancreas Society 2010.
Place of Presentation
福岡 福岡国際会議場
Year and Date
20100711-20100713
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[Presentation] Prognostic value of mTOR activation and therapeutic effects of everolimus in esophageal squamous cell carcinoma.2010
Author(s)
Hirashima K, Baba Y, Saito S, Kinoshita K, Satou N, Kurashige J, Karashima R, Imamura Y, Ikeda O, Hayashi N, Watanabe M, Iyama K, Baba H.
Organizer
AACR 101^<st> Annual Meeting
Place of Presentation
アメリカワシントンWalter E.Washington Convention Center
Year and Date
20100417-20100419
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