2010 Fiscal Year Final Research Report
Identification and characterization of cancer stem cells in gastrointestinal stromal tumors for overcome Glivec-resistance
| Project/Area Number |
20591579
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Keio University |
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Principal Investigator |
SAIKAWA Yoshiro Keio University, 医学部, 講師 (00225682)
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| Project Period (FY) |
2008 – 2010
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| Keywords | GIST / 癌幹細胞 / CD133 / グリベック |
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| Research Abstract |
Some evidences have suggested that CD133/Prominin1 is a marker for a subset of cancer stem like cells in solid tumors. Our study for the first time provided evidence that CD133 positive cancer stem cells display capability on tumorigenesis and resistance to glivec. CD133 is expressed in the minority of GISTs, suggesting a novel, additional standard marker for identifying cancer stem cells (CSCs). Future studies should focus on the role of CD133 in the pathogenesis of GIST and subsequently on its potential to act as a molecular target for adjuvant therapy with new molecular antitumor agents.
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Research Products
(1 results)
