2010 Fiscal Year Final Research Report
Clinicopatological analysis of carcinogenesis of gastric carcinoma
| Project/Area Number |
20591580
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Hyogo College of Medicine |
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Principal Investigator |
SASAKO Mitsuru Hyogo College of Medicine, 医学部, 教授 (40143490)
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| Co-Investigator(Kenkyū-buntansha) |
KIKUCHI Shojiro 兵庫医科大学, 医学部, 講師 (70381960)
KAIBE Nobuaki 兵庫医科大学, 医学部, 病院助手 (40529351)
FUJIWARA Yoshinori 近畿大学, 医学部, 診療講師 (10258155)
YOSHIKAWA Reigetsu 神戸アベンチスト病院, 外科, 医師 (90319864)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 癌幹細胞 / ピロリ菌 / 食道 / 胃癌 / hedgehog情報伝達系 / シチジデアミナーゼ / 分化 |
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| Research Abstract |
Purpose
We focused to prognosis of gastric cancer patients, and the expression of AID/Epithelial-mesenchymal transition related gene in gastric cancer tissue.
Results
1. We established a database of gastric cancer patients in Hyogo Collage of Medicine, which contains clinical factor, pathological factors, the expression of AID/EMT related genes.
2. Clinicopathological features of gastric cancer are pathological heterogeneity and invasiveness. We performed quantitative real-time RT-PCR array for AID/EMT (84genes) using resected gastric cancer tissue in our hospital. EMT related gene was significantly related to invasiveness of diffuse type of cancer.
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[Journal Article] Clinical Significance of Circulating Tumor Cells, Including Cancer Stem-Like Cells, in Peripheral Blood for Recurrence and Prognosis in Patients with Dukes' Stage B and C Colorectal Cancer.2011
Author(s)
H.Iinuma, T Watanabe, K.Mimori, M.Adachi, N.Hayashi, J.Tamura, K.Matsuda, R.Fukushima, K.Okinaga, M.Sasako, M.Mori
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Journal Title
Journal of Clinical Oncology 20(12)
Pages: 1547-1555
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[Journal Article] A Large-Scale Study of MT1-MMP as a Marker for Isolated Tumor Cells in Peripheral Blood and Bone Marrow in Gastric Cancer Cases.2008
Author(s)
K.Mimori, T.Fukagawa, Y.Kosaka, K.Ishikawa, M.Iwatasuki, T.Yokobori, S.Hirasaki, Y.Takatsuno, H.Sakashita, H.Ishii, M.Sasako, M.Mori
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Journal Title
Annals of Surgical Oncology 15(10)
Pages: 2934-2942
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[Journal Article] Identification of prognostic biomarkers in gastric cancer using endoscopic biopsy samples.2008
Author(s)
Y.Yamada, T.Arao, T.Gotoda, H.Taniguchi, I.Oda, K.Shirao, Y.Shimada, T.Hamaguchi, K.Kato, T.Hamano, F. Koizumi, T.Tamura, D.Saito, T.Shimoda, M.Saka, T.Fukagawa, H.Katai, T.Sano, M.Sasako, K.Nishio
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Journal Title
Cancer Science 99(11)
Pages: 2193-2199
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