2010 Fiscal Year Final Research Report

Molecular mechanism for the low invasiveness of laparoscopic surgery

Research Project

Project/Area Number	20591590
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Digestive surgery
Research Institution	Hiroshima University
Principal Investigator	OKAJIMA Masazumi Hiroshima University, 病院, 特任教授 (90274068)
Co-Investigator(Kenkyū-buntansha)	IKEDA Satoshi 広島大学, 大学院・医歯薬学総合研究科, 寄付講座講師 (60397924)
Project Period (FY)	2008 – 2010
Keywords	腹腔鏡手術 / 低侵襲手術 / 分子生物学
Research Abstract	We investigated the molecular mechanism for the low invasiveness of laparoscopic surgery. 1. Portal vein blood pH, hepatic function, and hepatic histology were disturbed in a porcine carbon dioxide pneumoperitoneum model. It may be necessary to pay attention to liver damage during laparoscopic surgery. 2. Post operative adhesions were suppressed in rat pneumoperitoneum model compared to open surgery. Plasminogen activator inhibitor-1 (PAI-1) level, which is a key molecule for post operative adhesion formation, was suppressed in serum and peritoneal lavage in pneumoperitoneum model. The PAI-1 mRNA level measured from rat and human omentum were also suppressed, which implied the mechanism of reduction for postoperative adhesions in laparoscopic surgery.

(2 results)