2010 Fiscal Year Final Research Report
T cell function in ulcerative colitis, particularly relationship between osteopontin and ulcerative colitis
| Project/Area Number |
20591595
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Nihon University |
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Principal Investigator |
MASUDA Hideki Nihon University, 医学部, 教授 (40173752)
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| Co-Investigator(Kenkyū-buntansha) |
HAYAKAWA Satoshi 日本大学, 医学部, 教授 (30238084)
TAKAHASHI Yasuo 日本大学, 医学部, 准教授 (30339329)
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| Co-Investigator(Renkei-kenkyūsha) |
AIZAWA Shihoko 日本大学, 医学部, 助手 (30513858)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 潰瘍性大腸炎 / クローン病 / 炎症性腸疾患 / オステオポンテイン |
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| Research Abstract |
We simultaneously examined plasma OPN levels and 17 cytokines. In UC patients, significant relationships were observed between plasma OPN levels and cytokines including IL-1β, IL-4, IL-5, IL-6, IL-7, IL-13, IFN-γ, TNF-α and GM-CSF. In the CD patients, we observed a remarkable correlation solely between OPN and IL-8. In conclusion, we posit the importance of OPN in reflecting the distinct pathophysiologies of UC and CD.
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