2010 Fiscal Year Final Research Report
SOX Family Regulate Colon Cancer Progression through Wnt Signaling.
| Project/Area Number |
20591599
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Tazuke Kofukai Medical Research Institute |
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Principal Investigator |
HASHIDA Hiroki Tazuke Kofukai Medical Research Institute, 医学研究所第1研究部, 研究員 (70281607)
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| Project Period (FY) |
2008 – 2010
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| Keywords | SOX4 / SOX family / 大腸癌 / 大腸発生 / ワクチン療法 / microRNA |
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| Research Abstract |
When the appearance of SOX4 was a strong positivity by inducing SOX4 tocolon cancer cell, it turned out that the shift of beta-catenin to the nucleus was changed, and the disease stage advanced, and the prognosis was poor. In the examination for microRNA signature, it was thought that the progress of colon cancer had happened because of strength of signature. It was suggested that SOX4 controls the Wnt signaling by beta-catenin, and was thought the possibility of taking part in generating and making of colon cancer. It was suggested that there was a possibility of the one by the introduction of microRNA as a vaccine therapy of SOX4.
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Research Products
(12 results)
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[Journal Article] Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling2011
Author(s)
Masahiro Sonoshita, Masahiro Aoki, Haruhiko Fuwa, Koji Aoki, Hisahiro Hosogi, Yoshiharu Sakai, Hiroki Hashida, Arimichi Takabayashi, Makoto Sasaki, Sylvie Robine, Kazuyuki Itoh, Kiyoko Yoshioka, Fumihiko Kakizaki, Takanori Kitamura, Masanobu Oshima, Makoto Mark Taketo
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Journal Title
Cancer Cell Vol.19、No.1
Pages: 125-137
Peer Reviewed
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