2010 Fiscal Year Final Research Report
New therapeutic approach with bone marrow cell for hereditary liver diseases
| Project/Area Number |
20591604
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Shinshu University |
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Principal Investigator |
NAKATA Takenari Shinshu University, 医学部附属病院, 講師 (70377638)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAGAWA Shinichi 信州大学, 医学部, 教授 (80229806)
MOTOYAMA Hiroaki 信州大学, 医学部附属病院, 助教(特定雇用) (20569587)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 移植医療 / 再生医療 / 骨髄移植 |
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| Research Abstract |
We used Long Evans Cinnamon (LEC) rats as recipients, a model of Wilson disease and liver carcinogenesis. GFP-expressing BMCs were injected into newborn LEC rats through the spleen.
At 18 months after injection, we found some green fluorescent protein-expressing areas macroscopically in the liver of treated LEC rats. The oxidative activity of ceruloplasmin increased. Moreover, we confirmed that the BMDHs were generated by cell fusion and was not detected in any of the neoplastic lesions or cholngiofibrotic regions.
Our results suggest that this novel strategy for creating BMDHs is effective and safe.
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[Journal Article] COP35, a cholangiocarcinoma-binding oligo-peptide, interacts with the clathrin heavy chain accompanied by GRP78.2011
Author(s)
Kitahara H, Masumoto J, Parker AL, Maruta F, Kubo N, Shimizu A, Akita N, Miwa S, Kobayashi N, Nakayama J, Miyagawa S.
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Journal Title
Peer Reviewed
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[Journal Article] Adrenomedullin in sinusoidal endothelial cells play protective roles against cold injury of liver.2010
Author(s)
Iinuma N, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Arai T, Yoshizawa T, Koyama T, Uetake R, Kawate H, Muto S, Tagawa Y, Miyagawa S, Shindo T.
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Journal Title
Peptides. 31
Pages: 865-871
Peer Reviewed
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[Journal Article] Primary liver carcinoma exhibiting dual hepatocellular-biliary epithelial differentiations associated with citrin deficiency.2008
Author(s)
Soeda J, Yazaki M, Nakata T, Miwa S, Ikeda S, Hosoda W, Iijima M, Kobayashi K, Saheki T, Kojiro M, Miyagawa S.
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Journal Title
J Clin Gastroenterol. 42
Pages: 855-860
Peer Reviewed
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