2010 Fiscal Year Final Research Report
The role of PPARγ in bile duct ligation-induced hepatic injury in rats.
| Project/Area Number |
20591608
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Nagoya University |
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Principal Investigator |
EBATA Tomoki Nagoya University, 医学系研究科, 講師 (60362258)
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| Co-Investigator(Kenkyū-buntansha) |
KOKURYO Toshio 名古屋大学, 大学院・医学系研究科, 特任助教 (60378023)
YOKOYAMA Yukihiro 名古屋大学, 大学院・医学系研究科, 寄附講座講師 (80378091)
NAGINO Masato 名古屋大学, 大学院・医学系研究科, 教授 (20237564)
SUGAWARA Gen 名古屋大学, 医学部附属病院, 助教 (00402587)
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| Project Period (FY) |
2008 – 2010
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| Keywords | PPAR_Y / 15D-PGJ_2 |
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| Research Abstract |
In this study, we sought to determine the effects of PPAR_Y modulation on bile duct ligation (BDL)-induced hepatic injury and on lipopolysaccharide (LPS)-induced acute obstructive cholangitis.
PPAR_Y activation with PGJ2 can be a potent therapeutic option for hepatic injury under the condition of biliary obstruction and acute obstructive cholangitis
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