2010 Fiscal Year Final Research Report
Basic analysis of anti-allergic agent MMKY-01, which accelerating drug sensitivity to gemicitabine in pancreatic cancer cell.
| Project/Area Number |
20591632
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Saga University |
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Principal Investigator |
KITAJIMA Yoshihiko Saga University, 医学部, 客員研究員 (30234256)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 膵癌 / 胆嚢癌 / ジェムシタビン / MMKY-01 / RRM1 / ユビキチン / TGF-β |
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| Research Abstract |
The present study demonstrated that MMKY-01 accelerates drug sensitivity to gemcitabine via decreasing RRM1 expression in pancreatic and gall bladder (GB) cancer cells. The reduced RRM1 expression was derived through ubiquitin-proteosome pathway in pancreatic cancer. Further analysis revealed that MMKY-01 rendered gemcitabine resistant GB cancer cell to apoptosis. These results indicated that MMKY-01 plus gemcitabine is possibly effective to pancreatic as well as GB cancer. Especially, MMKY-01 treatment was revealed to reverse the gemcitabine resistance in GB cancer.
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