2010 Fiscal Year Final Research Report
Proteomic analysis of the regulation of proteins by NO-induced posttranslational modification and anti-cancer therapy
| Project/Area Number |
20591633
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
SUGITA Hiroki Kumamoto University, 医学部附属病院, 非常勤診療医師 (30398218)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAMORI Hiroshi 熊本大学, 大学院・生命科学研究部, 講師 (90363514)
HIROTA Masahiko 熊本大学, 医学部附属病院, 非常勤診療医師 (80284769)
KAMOHARA Hidenobu 熊本大学, 医学部附属病院, 講師 (90398222)
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| Project Period (FY) |
2008 – 2010
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| Keywords | insulin / IGFシグナル / 癌 / 一酸化窒素(NO) / ユビキチン化 / IGF-I |
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| Research Abstract |
NO inhibits the phosphorylation of IGF-IR, EGFR, Akt and IRS-1 protein expression, but upregulates Ras/Erk pathway in cancer cells (pancreatic and colon cancer cells). C terminus is responsible site for NO-induced ubiqutination and degradation of IRS-1 protein. NO inhibits the proliferation and invasion of pancreatic, colon and breast cancer cells. Combination of NO-donor and MEK-inhibitor enhances anti-cancer activity in these cancer cells.
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Research Products
(12 results)
