Is it possible to develop radical treatment of cancer based on cancer stem cell theory?

2010 Fiscal Year Final Research Report

• Project/Area Number: 20591634
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kumamoto University
• Principal Investigator: TAKAMORI Hiroshi Kumamoto University, 大学院・生命科学研究部, 講師 (90363514)
• Co-Investigator(Kenkyū-buntansha): HIROTA Masahiko 熊本大学, 医学部附属病院, 非常勤診療医師 (80284769) ; HAYASHI Naoko 熊本大学, 医学部附属病院, 非常勤診療医師 (20452899) ; HORINO Kei 熊本大学, 医学部附属病院, 非常勤診療医師 (60452900)
• Co-Investigator(Renkei-kenkyūsha): OHMURAYA Masaki 熊本大学, 発生医学研究センター, 研究機関 (60398229)
• Project Period (FY): 2008 – 2010
• Keywords: がん幹細胞 / ポリコーム群蛋白 / Bmi-1 / EZH-2 / 膵癌 / 膵管内乳頭状粘液腫瘍 / 発癌

Research Abstract

Bmi-1, which is one of the polycomb group protein, is expressed in the nucleus of the cancer cells, but is not expressed in stroma cells in the pancreatic cancer tissues. There was no specific characteristic of expression of Bmi-1, that is, Bmi-1 distributes in the tumor tissue diffusely. There was no statistical significance of prognosis between Bmi-1 expression cases and a non-expression case of Bmi-1. EZH-2, which is also one of the polycomb group protein, is not expressed in normal pancreatic duct and adenoma, but is expressed in cancer cells. It indicated that EZH-2 might be contributed to carcinogenesis of pancreatic cancer.

Research Products

• [Journal Article] Clinical significance of circulating tumor cells, including cancer stem-like cells, in peripheral blood for recurrence and prognosis in patients with dukes' stage Band C colorectalcancer. (2011)
  • Author(s): H.Iinuma, T.Watanabe, K.Mimori, M.Adachi, N.Hayashi, J.Tamura, K.Matsuda, R.Fukushima, K.Okinaga, M.Sasako, M.Mori.
  • Journal Title: J.Clin.Oncol. 29 Pages: 1547-1555
  • Peer Reviewed
• [Journal Article] Perioperative intra-arterial and systemic chemoth erapy for pancreatic cancer. (2011)
  • Author(s): H.Takamori, K.Kanemitsu, M.Hirota, O.Ikeda, H.Tanaka, T.Beppu, Y.Yamashita, N.Oya, H.Baba.
  • Journal Title: Ann.Surg.Oncol. 18 Pages: 1110-1115
  • Peer Reviewed
• [Journal Article] Clinical Significance of Wnt-induced Secreted Protein-1(WISP-1/CCN4) in Esophageal Squamous Cell Carcinoma. (2011)
  • Author(s): Y.Nagai, M.Watanabe, S.Ishikawa, R.Karashima, J.Kurashige, S.Iwagami, M.Iwatsuki, Y.Baba, Y.Imamura, N.Hayashi, H.Baba.
  • Journal Title: Anticancer Res. 31 Pages: 991-997
  • Peer Reviewed
• [Journal Article] Extensive lymphatic spread of cancer cells in patients with thoracic esophageal squamous cell carcinoma : detection of CEA-mRNA in the three-field lymph nodes. (2010)
  • Author(s): Y.Imamura, N.Hayashi, N.Sato, K.Kinoshita, J.Kurashige, S.Saito, K.Hirashima, R.Karashima, Y.Hiyoshi, Y.Nagai, M.Watanabe, H.Baba.
  • Journal Title: J.Surg.Oncol. 102 Pages: 509-515
  • Peer Reviewed
• [Journal Article] Phosphorylated mTOR expression is associated with poor prognosis for patients with esophageal squamous cell carcinoma. (2010)
  • Author(s): K.Hirashima, Y.Baba, M.Watanabe, R.Karashima, N.Sato, Y.Imamura, Y.Hiyoshi, Y.Nagai, N.Hayashi, K.Iyama, H.Baba.
  • Journal Title: Ann.Surg.Oncol. 17 Pages: 2486-2493
  • Peer Reviewed
• [Journal Article] Nitricoxide inhibits the proliferation and invasion of pancreatic cancer cells through degradation of insulin receptor substrate-1 protein. (2010)
  • Author(s): H.Sugita, M.Kaneki, S.Furuhashi, M.Hirota, H.Takamori, H.Baba.
  • Journal Title: Mol.Cancer Res. 8 Pages: 1152-1163
  • Peer Reviewed
• [Journal Article] Interdigitating dendritic cell sarcoma of the ileum recurred in multiple lymph nodes and duodenum three years after operation without chemotherapy. (2010)
  • Author(s): S.Ishihara, Y.Honda, T.Asato, M.Nonaka, S.Nakagawa, K.Hirashima, N.Hayashi, H.Baba, K.Iyama.
  • Journal Title: Pathol.Res.Pract. 206 Pages: 514-518
  • Peer Reviewed
• [Journal Article] Can the physiologic ability and surgicalstress (E-PASS) scoring system predict operative morbidity after distal pancreatectomy? (2010)
  • Author(s): D.Hashimoto, H.Takamori, Y.Sakamoto, H.Tanaka, M.Hirota, H.Baba.
  • Journal Title: Surg.Today. 40 Pages: 632-637
  • Peer Reviewed
• [Journal Article] Pancreato duodenectomy using a no-touch isolation technique. (2010)
  • Author(s): M.Hirota, K.Kanemitsu, H.Takamori, A.Chikamoto, H.Tanaka, H.Sugita, J.Sand, I.Nordback, H.Baba.
  • Journal Title: Am.J.Surg. 199 Pages: e65-e68
  • Peer Reviewed
• [Journal Article] Relationship of strain-ependent susceptibility to experimentally induced acute pancreatitis with regulation of Prss1 and Spink3 expression. (2010)
  • Author(s): J.Wang, M.Ohmuraya, K.Suyama, M.Hirota, N.Ozaki, H.Baba, N.Nakagata, K.Araki, K.Yamamura.
  • Journal Title: Lab.Invest. 90 Pages: 654-664
  • Peer Reviewed
• [Journal Article] The role of oxysterol binding protein-related protein 5 inpancreatic cancer. (2010)
  • Author(s): S.Ishikawa, Y.Nagai, T.Masuda, Y.Koga, T.Nakamura, Y.Imamura, H.Takamori, M.Hirota, A.Funakosi, M.Fukushima, H.Baba.
  • Journal Title: Cancer Sci. 101 Pages: 898-905
  • Peer Reviewed
• [Journal Article] FOLFOX enables high resectability and excellent prognosis for initially unresectable colorectal liver metastases. (2010)
  • Author(s): T.Beppu, N.Hayashi, T.Masuda, H.Komori, K.Horino, H.Hayashi, H.Okabe, Y.Baba, K.Kinoshita, C.Akira, M.Watanebe, H.Takamori, H.Baba.
  • Journal Title: Anticancer Res. 30 Pages: 1015-1020
  • Peer Reviewed
• [Journal Article] Is an estimation of physiologic ability and surgical stress able to predict operative morbidity after ancreaticoduodenectomy? (2010)
  • Author(s): D.Hashimoto, H.Takamori, Y.Sakamoto, Y.Ikuta, O.Nakahara, S.Furuhashi, H.Tanaka, M.Watanabe, T.Beppu, M.Hirota, H.Baba.
  • Journal Title: J.Hepatobiliary.Pancreat.Sci. 17 Pages: 132-138
  • Peer Reviewed
• [Journal Article] Adenoviral oncolytic suicide gene therapy for a peritoneal dissemination model of gastric cancer in mice. (2010)
  • Author(s): Y.Imamura, S.Ishikawa, N.Sato, R.Karashima, K.Hirashima, Y.Hiyoshi, Y.Nagai, Y.Koga, N.Hayashi, M.Watanabe, G.Yamada, H.Baba.
  • Journal Title: Ann.Surg.Oncol. 17 Pages: 643-652
  • Peer Reviewed
• [Journal Article] Clinical significance of dihydropyrimidine dehydrogenase and thymidylate synthase expression in patients with ancreatic cancer. (2010)
  • Author(s): O.Nakahara, H.Takamori, H.Tanaka, Y.Sakamoto, Y.Ikuta, S.Furuhashi, M.Watanabe, T.Beppu, M.Hirota, K.Kanemitsu, H.Baba.
  • Journal Title: Int.J.Clin.Oncol. 15 Pages: 39-45
  • Peer Reviewed
• [Journal Article] Treatment results of FOLFOX chemotherapy before surgery for lymph node metastasis of advanced colorectal cancer with synchronous liver metastasis: the status of LN metastasis and vessel invasions at the primary site in patients who responded to FOLFOX. (2010)
  • Author(s): H.Sawayama, N.Hayashi, S.Honda, Y.Baba, E.Toyama, M.Watanabe, H.Takamori, T.Beppu, H.Baba.
  • Journal Title: Int.J.Clin.Oncol. 15 Pages: 70-76
  • Peer Reviewed
• [Journal Article] Recanalization of obstructed choledo chojejunostomy using the magnet compression anastomosis echnique. (2010)
  • Author(s): K.Suyama, H.Takamori, E.Yamanouchi, H.Tanaka, Y.Sakamoto, Y.Ikuta, Y.Maki, K.Sakurai, M.Hirota, H.Baba.
  • Journal Title: Am.J.Gastroenterol. 105 Pages: 230-231
  • Peer Reviewed
• [Journal Article] Significance of renal rimgrade on omputed tomography in severity evaluation of acute pancreatitis. (2010)
  • Author(s): Y.Imamura, M.Hirota, S.Ida, N.Hayashi, M.Watanabe, H.Takamori, K.Awai, H.Baba.
  • Journal Title: Pancreas 39 Pages: 41-46
  • Peer Reviewed
• [Journal Article] Chronic pancreatitis in mice by treatment with choline-deficient ethionine-supplemented diet. (2010)
  • Author(s): S.Ida, M.Ohmuraya, M.Hirota, N.Ozaki, S.Hiramatsu, H.Uehara, H.Takamori, K.Araki, H.Baba, K.Yamamura.
  • Journal Title: Exp.Anim. 59 Pages: 421-429
  • Peer Reviewed
• [Journal Article] MicroRNA-21 regulates the proliferation and invasion in esophageal squamous cell carcinoma. (2010)
  • Author(s): Y.Hiyoshi, H.Kamohara, R.Karashima, N.Sato, Y.Imamura, Y.Nagai, N.Yoshida, E.Toyama, N.Hayashi, M.Watanabe, H.Baba.
  • Journal Title: Clin.Cancer Res. 15 Pages: 915-1922
  • Peer Reviewed
• [Journal Article] Rapid genotyping of tumor necrosis factor alpha with fluorogenic hybridization probes on the LightCycler. (2010)
  • Author(s): N.Hayashi, Y.Imamura, Y.Hiyoshi, H.Takamori, T.Beppu, M.Hirota, H.Baba.
  • Journal Title: Clin.Exp.Med. 8 Pages: 217-224
  • Peer Reviewed
• [Journal Article] Neuroendocrine tumor of the rectum. (2009)
  • Author(s): K.Suyama, N.Hayashi, H.Shigaki, N.Sato, K.Hirashima, Y.Nagai, Y.Hiyoshi, Y.Sakamoto, N.Yoshida, E.Toyama,M.Watanabe, H.Baba.
  • Journal Title: Am.J.Surg. 198 Pages: e39-e41
  • Peer Reviewed
• [Journal Article] Serine protease inhibitor Kazal type 1 promotes proliferation of pancreatic cancer cells through the epidermal growth factor receptor. (2009)
  • Author(s): N.Ozaki, M.Ohmuraya, M.Hirota, S.Ida, J.Wang, H.Takamori, S.Higashiyama, H.Baba, K.Yamamura.
  • Journal Title: Mol.Cancer Res. 7 Pages: 1572-1581
  • Peer Reviewed
• [Journal Article] Pattern of lymph node involvement in proximal gastric cancer. (2009)
  • Author(s): S.Ishikawa, S.Shimada, N.Miyanari, M.Hirota, H.Takamori, H.Baba.
  • Journal Title: World J.Surg. 33 Pages: 1687-1692
  • Peer Reviewed
• [Journal Article] Effect of low-molecular weight trypsin inhibitor, nafamostat mesilate, on trypsin activity using the pancreatic acinar cells. (2009)
  • Author(s): D.Hashimoto, M.Ohmuraya, J.Wang, K.Yamamura, M.Hirota, H.Baba.
  • Journal Title: Pancreas 38 Pages: 595-597
  • Peer Reviewed
• [Journal Article] Transcervical superior mediastinal lymph node dissection combined with transhiatal lower esophageal dissection before transthoracic esophagectomy : a safe approach for salvage esophagectomy. (2009)
  • Author(s): M.Watanabe, N.Yoshida, R.Karashima, N.Sato, K.Hirashima, Y.Imamura, Y.Hiyoshi, Y.Nagai, S.Iwagami, E.Toyama, N.Hayashi, H.Baba.
  • Journal Title: J.Am.Coll.Surg. 208 Pages: e7-e9
  • Peer Reviewed
• [Journal Article] Spleen and gastrosplenic ligament preserving distal pancreatectomy under aminimum incision approach assisted by laparoscopy. (2009)
  • Author(s): M.Hirota, A.Ichihara, S.Furuhashi, H.Tanaka, H.Takamori, H.Baba.
  • Journal Title: J.Hepatobiliary.Pancreat.Surg. 16 Pages: 792-795
  • Peer Reviewed
• [Journal Article] Cancer cells spread through lymphvessels in the submucosal layer of the common bile duct in gallbladder carcinoma. (2009)
  • Author(s): A.Chikamoto, T.Tsuji, O.Nakahara, Y.Sakamoto, Y.Ikuta, H.Tanaka, H.Takamori, M.Hirota, K.Kanemitsu, H.Baba.
  • Journal Title: J.Hepatobiliary.Pancreat.Surg. 16 Pages: 557-561
  • Peer Reviewed
• [Journal Article] The relationship between the glucose transporter type 1 expression and F-fluorodeoxyg lucose uptake in esophageal squamous cell carcinoma. (2009)
  • Author(s): Y.Hiyoshi, M.Watanabe, Y.Imamura, Y.Nagai, Y.Baba, N.Yoshida, E.Toyama, N.Hayashi, H.Baba.
  • Journal Title: Oncology 76 Pages: 286-292
  • Peer Reviewed
• [Journal Article] Multiple gastrointestinal stromal tumors in neurofibroma tosis type 1 : report of a case. (2009)
  • Author(s): K.Hirashima, H.Takamori, M.Hirota, H.Tanaka, A.Ichihara, Y.Sakamoto, Y.Ikuta, R.Karashima, M.Watanabe, K.Iyama, H.Baba.
  • Journal Title: Surg.Today. 39 Pages: 979-983
  • Peer Reviewed
• [Journal Article] Oxysterol binding protein-related protein-5 is related to invasion and poor prognosis in pancreatic cancer. (2008)
  • Author(s): Y.Koga, S.Ishikawa, T.Nakamura, T.Masuda, Y.Nagai, H.Takamori, M.Hirota, K.Kanemitsu, Y.Baba, H.Baba.
  • Journal Title: Cancer Sci. 99 Pages: 2387-2394
  • Peer Reviewed
• [Journal Article] Percutaneous transfistulous pancreatic duct drainage and interventional pancreatojejunostomy as a treatment option for intractable pancreatic fistula. (2008)
  • Author(s): M.Hirota, K.Kanemitsu, H.Takamori, A.Chikamoto, N.Hayashi, K.Horino, H.Baba.
  • Journal Title: Am.J.Surg. 196 Pages: 280-284
  • Peer Reviewed
• [Journal Article] Expression pattern of serine protease inhibitor kazal type 3 (Spink3) during mouse embryonic development. (2008)
  • Author(s): J.Wang, M.Ohmuraya, M.Hirota, H.Baba, G.Zhao, M.Takeya, K.Araki, K.Yamamura.
  • Journal Title: Histochem.Cell Biol. 130 Pages: 387-397
  • Peer Reviewed
• [Journal Article] Platelet count asa sensitive and convenient parameter for assessing the prognosis in acute pancreatitis. (2008)
  • Author(s): Y.Fujimura, M.Hirota, A.Ichihara, H.Takamori, H.Baba.
  • Journal Title: Pancreas 37 Pages: 225-227
  • Peer Reviewed
• [Journal Article] Involvement of autophagy in trypsinogen activation within the pancreatic acinar cells. (2008)
  • Author(s): D.Hashimoto, M.Ohmuraya, M.Hirota, A.Yamamoto, K.Suyama, S.Ida, Y.Okumura, E.Takahashi, H.Kido, K.Araki, H.Baba, N.Mizushima, K.Yamamura.
  • Journal Title: J.Cell Biol. 181 Pages: 1065-1072
  • Peer Reviewed
• [Journal Article] C/EBP homologous protein is crucial for the acceleration of experimental pancreatitis. (2008)
  • Author(s): K.Suyama, M.Ohmuraya, M.Hirota, N.Ozaki, S.Ida, M.Endo, K.Araki, T.Gotoh, H.Baba, K.Yamamura.
  • Journal Title: Biochem.Biophys.Res.Commun. 367 Pages: 176-182
  • Peer Reviewed
• [Journal Article] The expression of type IV collagen alpha6 chain is related to the prognosis in patients with esophageal squamous cell arcinoma. (2008)
  • Author(s): Y.Baba, K.Iyama, K.Ikeda, S.Ishikawa, N.Hayashi, N.Miyanari, Y.Sado, Y.Ninomiya, H.Baba.
  • Journal Title: Ann.Surg.Oncol. 15 Pages: 555-565
  • Peer Reviewed
• [Journal Article] Heterogeneous prognoses of patients with tumors invaded within muscularis propria according to tumor depth in the ayers of the muscularis propria. (2008)
  • Author(s): Y.Imamura, Y.Baba, S.Ishikawa, Y.Hiyoshi, Y.Nagai, T.Nakamura, N.Hayashi, N.Miyanari, K.Iyama, H.Baba.
  • Journal Title: Gastric.Cancer 11 Pages: 219-225
  • Peer Reviewed
• [Journal Article] Long-term utcomes of extended radical resection combined with intraop erative radiation therapy for pancreatic ancer. (2008)
  • Author(s): H.Takamori, T.Hiraoka, K.Kanemitsu, T.Tsuji, H.Tanaka, A.Chikamoto, K.Horino, T.Beppu, M.Hirota, H.Baba.
  • Journal Title: J.Hepatobiliary.Pancreat.Surg. 15 Pages: 603-607
  • Peer Reviewed
• [Presentation] バイオマーカーを用いた進行・再発大腸癌に対する個別化治療の試み (2010)
  • Author(s): 林尚子
  • Organizer: 第48回日本癌治療学会学術集会
  • Place of Presentation: 京都 京都国際会館
  • Year and Date: 2010-10-28
• [Presentation] 遊離癌細胞(ITC)の同定と機能解析 (2010)
  • Author(s): 林尚子
  • Organizer: JDDW2010第8回日本消化器外科学会大会
  • Place of Presentation: 横浜 パシフィコ横浜
  • Year and Date: 2010-10-13
• [Presentation] 術後膵液瘻とそれに伴う腹腔内出血防止の工夫(Double Wrapping Method) (2010)
  • Author(s): 高森啓史
  • Organizer: JDDW2010第8回日本消化器外科学会大会
  • Place of Presentation: 横浜 パシフィコ横浜
  • Year and Date: 2010-10-13
• [Presentation] Perioprative chemotherapy for pancreatic cancer Joint Meeting of the International Association of Pancreatology and the Japan Pancreas Society 2010 (2010)
  • Author(s): 高森啓史
  • Organizer: 第14回国際膵臓学会・第41回日本膵臓学会合同会議
  • Place of Presentation: 福岡 福岡国際会議場
  • Year and Date: 2010-07-11
• [Presentation] 膵癌に対する術前化学療法と術後化学療法の比較-有害事象発生の観点から- (2010)
  • Author(s): 高森啓史
  • Organizer: 第22回日本肝胆膵外科学会
  • Place of Presentation: 仙台 仙台国際センター
  • Year and Date: 2010-05-26
• [Presentation] 膵癌治療成績向上に向けた試み-術前化学療法におけるCA19-9値の推移からの検討- (2010)
  • Author(s): 高森啓史
  • Organizer: 第96回日本消化器病学会総会
  • Place of Presentation: 新潟 新潟市音楽文化会館ホール
  • Year and Date: 2010-04-22
• [Presentation] オンコロジストとしての外科医に求められる基礎研究とは何か-ITC研究の知見から- (2010)
  • Author(s): 林尚子
  • Organizer: 第110回日本外科学会
  • Place of Presentation: 名古屋 名古屋国際会議場
  • Year and Date: 2010-04-08
• [Presentation] 膵癌に治癒はあるか-5年生存例の検討から- (2010)
  • Author(s): 高森啓史
  • Organizer: 第110回日本外科学会
  • Place of Presentation: 名古屋 名古屋国際会議場
  • Year and Date: 2010-04-08
• [Presentation] 5-Fluorouracil intra-arterial infusion combined with systemic gemcitabine for pancreatic cancer. 130 aptietns. (2009)
  • Author(s): 高森啓史
  • Organizer: 40th anniversary joint meeting of the American pancreatic association & Japan pancreas Society
  • Place of Presentation: アメリカハワイ ヒルトンハワイアンビレッジ
  • Year and Date: 2009-11-03
• [Presentation] 切除不能進行再発大腸癌肝転移に対する化学療法後肝切除の妥当性-経済的観点から- (2009)
  • Author(s): 林尚子
  • Organizer: 第47回日本癌治療学会学術集会
  • Place of Presentation: 神奈川 パシフィコ横浜
  • Year and Date: 2009-10-22
• [Presentation] 再発形式からみた膵癌長期生存の検討 (2009)
  • Author(s): 高森啓史
  • Organizer: JDDW(第51回日本消化器病学会)
  • Place of Presentation: 京都 京都国際会館
  • Year and Date: 2009-10-14
• [Presentation] Neoadjuvant and adjuvant chemotherapy (2009)
  • Author(s): 高森啓史
  • Organizer: 19th IASGO
  • Place of Presentation: 中国 北京 北京国際コンベンションセンター
  • Year and Date: 2009-09-23
• [Presentation] 局所進行膵癌に対する治療戦略 (2009)
  • Author(s): 高森啓史
  • Organizer: 第40回日本膵臓学会大会
  • Place of Presentation: 東京 慶應プラザホテル
  • Year and Date: 2009-07-30
• [Presentation] 高齢者(80歳以上)に対する膵切除術 (2009)
  • Author(s): 高森啓史
  • Organizer: 第64回日本消化器外科学会総会
  • Place of Presentation: 大阪 大阪国際会議場
  • Year and Date: 2009-07-16
• [Presentation] 膵癌に対する集学的治療施行例における早期死亡率の検討 (2009)
  • Author(s): 高森啓史
  • Organizer: 第21回日本肝胆膵外科学会・学術集会
  • Place of Presentation: 愛知 ウエスティンナゴヤキャッスル
  • Year and Date: 2009-06-10
• [Presentation] 膵癌に対する集学的治療施行例における長期生存の条件 (2009)
  • Author(s): 高森啓史
  • Organizer: 第109回日本外科学会
  • Place of Presentation: 福岡 福岡国際会議場
  • Year and Date: 2009-04-02
• [Presentation] 膵癌外科治療の有用性と限界 (2009)
  • Author(s): 高森啓史
  • Organizer: 第23回冬期札幌がんセミナーいまがんを考える2009
  • Place of Presentation: 北海道 ロイトン札幌
  • Year and Date: 2009-02-07
• [Presentation] 膵癌の対する術前化学療法の意義 (2008)
  • Author(s): 高森啓史
  • Organizer: 第46回日本癌治療学会総会
  • Place of Presentation: 愛知名古屋国際会議場
  • Year and Date: 2008-10-30
• [Presentation] 直腸癌に対する集学的治療-直腸癌局所再発の外科治療を中心に- (2008)
  • Author(s): 林尚子
  • Organizer: 第46回日本癌治療学会総会
  • Place of Presentation: 愛知名古屋国際会議場
  • Year and Date: 2008-10-30
• [Presentation] A novel mltimodality treatment for pancreatic cancer. (2008)
  • Author(s): 高森啓史
  • Organizer: 8th International conference of anticancer research
  • Place of Presentation: ギリシア Norida Hotel
  • Year and Date: 2008-10-22
• [Presentation] 膵癌治療における局所動注全身化学療法の有用性 (2008)
  • Author(s): 高森啓史
  • Organizer: 第39回日本膵臓学会大会
  • Place of Presentation: 横浜パシフィコ横浜
  • Year and Date: 2008-07-29
• [Presentation] 再発大腸癌に対する治療の現状と展望 (2008)
  • Author(s): 林尚子
  • Organizer: 第63回日本消化器外科学会総会
  • Place of Presentation: 北海道 札幌プリンスホテルパミール
  • Year and Date: 2008-07-16
• [Presentation] Isolated tumor cell の臨床的意義と臨床応用の可能性 (2008)
  • Author(s): 林尚子
  • Organizer: 第108回日本外科学会定期学術集会長崎
  • Place of Presentation: 長崎 長崎ブリックホール
  • Year and Date: 2008-05-15
• [Presentation] 切除適応膵癌治療における最適の補助化学療法は何か? (2008)
  • Author(s): 高森啓史
  • Organizer: 第108回日本外科学会定期学術集会
  • Place of Presentation: 長崎 長崎新聞文化ホール
  • Year and Date: 2008-05-15