• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2010 Fiscal Year Final Research Report

Establishment of the hepatic reserve and molecular biological

Research Project

  • PDF
Project/Area Number 20591635
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionUniversity of Miyazaki

Principal Investigator

CHIJIIWA Kazuo  University of Miyazaki, 医学部, 教授 (90179945)

Co-Investigator(Kenkyū-buntansha) KONDO Kazuhiro  宮崎大学, 医学部, 准教授 (10244196)
KAI Masahiro  宮崎大学, 医学部, 講師 (40264379)
OHUCHIDA Jiro  宮崎大学, 医学部, 助教 (10363590)
HIDAKA Hidek  宮崎大学, 医学部, 助教 (90398264)
UCHIYAMA Shuichiro  宮崎大学, 医学部, 助教 (50437935)
NAGAIKE Koki  宮崎大学, 医学部, 助教 (70437937)
Project Period (FY) 2008 – 2010
Keywords大量肝切除 / 閉塞性黄疸 / 肝不全 / トランスポーター / 門脈塞栓
Research Abstract

Excessive hepatectomy close to the hepatic reserve function has a risk to induce postoperative liver failure. The mechanisms inducing hyperbiliruninemia with respect to anion transporters were examined in rats after 90% hepatectomy and found that excreting transporter expression (Bsep, Mrp3) but not the uptake transporters (NTCP, OATP) showed a significant difference compared to 70% hepatectomy. Moreover, Biomarkers (Glypican-3, HAI-1) influencing prognosis were established in hepatocellular carcinoma.

  • Research Products

    (18 results)

All 2011 2010 2009 2008 Other

All Journal Article (10 results) Presentation (5 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Prognostic Significance of Circumferential Cell Surface Immunoreactivity of Glypican-3 in Hepatocellular Carcinoma.2011

    • Author(s)
      Yorita, K., Takahashi, N., Takai, H., Kato, A., Suzuki, M., Ishiguro, T., Ohtomo, T., Nagaike, K., Kondo, K., Chijiiwa, K., Kataoka, H.
    • Journal Title

      Liver International 31(1)

      Pages: 120-131

  • [Journal Article] Expression of Hepatocyte Growth Factor Activator Inhibitor Type 1 in Human Hepatocellular Carcinoma and Postoperative Outcomes.2010

    • Author(s)
      Funagayama, M., Kondo, K., Chijiiwa, K., Kataoka, H.
    • Journal Title

      World Journal of Surgery 34(7)

      Pages: 1563-1571

  • [Journal Article] Predictive Value of Tc-99m Galactosyl Human Serum Albmin Liver SPECT on the Assessment of Functional Recovery after Partial Hepatectomy:A Comparison with CT Volumetry.2010

    • Author(s)
      Wakamatsu, H., Nagamachi, S., Kiyohara, S., Fujita, S., Kamimura, K., Nishi, R., Nagano, M., Kondou, K., Chijiiwa, K., Tamura, S
    • Journal Title

      Annals of Nuclear Medicine 24(10)

      Pages: 729-734

  • [Journal Article] Effects of Bile Acids on Rat Hepatic Mirosomal Type I 11β-hydroxysteroid Dehydrogenase.2010

    • Author(s)
      Maeda, Y., Naganuma, S., Niina, I., Shinohara, A., Koshimoto, C., Kondo, K., Chijiiwa, K.
    • Journal Title

      Steroids 75(2)

      Pages: 164-168

  • [Journal Article] Dickkopf-1 is Overexpressed in Human Pancreatic Ductal Adenocarcinoma Cells and is Involved in Invasive Growth.2010

    • Author(s)
      Takahashi, N., Fukushima, T., Yorita, K., Tanaka, H., Chijiiwa, K., Kataoka, H.
    • Journal Title

      International Journal of Cancer 126(7)

      Pages: 1611-1620

  • [Journal Article] Surgical Strategy for Hepatocellular Carcinoma Patients with Portal Vein Tumor Thrombus Based on Prognostic Factors.2009

    • Author(s)
      Kondo, K., Chijiiwa, K., Kai, M., Otani, K., Nagaike, K., Ohuchida, J., Hiyoshi, M., Nagano, M.
    • Journal Title

      Journal of Gastrointestinal Surgery 13(6)

      Pages: 1078-1083

  • [Journal Article] Prospective Randomized Controlled Study of Gastric Emptying Assessed by ^<13>C-Acetate Breath Test After Pylorus-Preserving Pancreaticoduodenectomy. Comparison between Antecolic and Vertical Retrocolic Duodenojejunostomy.2009

    • Author(s)
      Chijiiwa, K., Imamura, N., Ohuchida, J., Hiyoshi, M., Nagano, M., Otani, K., Kai, M., Kondo, K.
    • Journal Title

      Journal of Hepato-Biliary-Pancreatic Surgery 16(1)

      Pages: 49-55

  • [Journal Article] Differential Expression of Organic Anion Transporters in Rats Subjected to 70% or 90% Hepatectomy.2009

    • Author(s)
      Sano, K., Chijiiwa, K., Kai, M., Hidaka, Y., Kanemaru, M.
    • Journal Title

      Hepato-Gastroenterology 56(89)

      Pages: 176-180

  • [Journal Article] Clinicopathologic Characteristics of Hepatocellular Carcinoma with Bile Duct Invasion.2009

    • Author(s)
      Ikenaga, N., Chijiiwa, K., Otani, K., Ohuchida, J., Uchiyama, S., Kondo, K.
    • Journal Title

      Journal of Gastrointestial Surgery 13(1)

      Pages: 492-497

  • [Journal Article] Outcome of Surgical Treatment of Hilar Cholangiocarcinoma.2008

    • Author(s)
      Otani, K., Chijiiwa, K., Kai, M., Ohuchida, J., Nagano, M., Tsuchiya, K., Kondo, K.
    • Journal Title

      Journal of Gastrointest Srugery 12(6)

      Pages: 1033-1040

  • [Presentation] Prognostic Significance of 1. Circumferential Cell Surface Immunoreactivity of Glypican-3 in Hepatocellular Carcinoma.2011

    • Author(s)
      Yorita, K., Takahashi, N., Kato, A., Suzuki, M., Ishiguro, T., Ohtomo, T., Kondo, K., Chijiiwa,K, Kataoka, H.
    • Organizer
      The 3rd JCA-AACR Special Joint Conference : The Latest Advance in Liver Cancer Research
    • Place of Presentation
      Chiba
    • Year and Date
      20110301-20110303
  • [Presentation] 肝細胞癌に対する担癌領域門脈先行クランプによる系統的肝切除術2010

    • Author(s)
      近藤千博, 千々岩一男, 甲斐真弘, 大谷和広, 長池幸樹, 大内田次郎, 旭吉雅秀, 永野元章
    • Organizer
      第110回日本外科学会定期学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      20100408-20100410
  • [Presentation] ラット急性肝不全モデルにおける有機アニオントランスポーターの変動2009

    • Author(s)
      佐野浩一郎, 千々岩一男, 甲斐真弘, 日高淑晶, 金丸幹郎
    • Organizer
      第64回日本消化器外科学会総会
    • Place of Presentation
      大阪
    • Year and Date
      20090716-20090718
  • [Presentation] ミニシンポジウム3;肝予備能の評価:ICG血中停滞率とGSA R-maxによる肝予備能評価と肝切除術後残肝機能との相関について2009

    • Author(s)
      近藤千博, 千々岩一男, 甲斐真弘, 大谷和広, 長池幸樹, 大内田次郎, 旭吉雅秀, 永野元章, 長町茂樹
    • Organizer
      第21回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      20090610-20090612
  • [Presentation] シンポジウム3:胆道癌における進展度診断の新展開:胆道癌の進展度診断と予後因子2009

    • Author(s)
      甲斐真弘, 千々岩一男, 大内田次郎, 近藤千博, 大谷和広, 長池幸樹, 永野元章, 旭吉雅秀, 今村直哉
    • Organizer
      第109回日本外科学会定期学術集会
    • Place of Presentation
      福岡
    • Year and Date
      20090402-20090404
  • [Book] 肝良性腫瘍(消化器疾患の最新の治療2009-2010.:16.)2009

    • Author(s)
      近藤千博, 千々岩一男
    • Total Pages
      447(342-344)
    • Publisher
      南江堂
  • [Book] Digestive Surgery NOw No.4胆・膵外科標準手術操作のコツとトラブルシューティング:総胆管拡張症手術2009

    • Author(s)
      大内田次郎、千々岩一男
    • Total Pages
      169(72-86)
    • Publisher
      メジカルビュー社
  • [Remarks] ホームページ等

    • URL

      http://www.med.my/in

URL: 

Published: 2012-01-26   Modified: 2014-08-15  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi