Reserch of large maf transcription factors on pancreatic cell and preadipocyte differentiation

2010 Fiscal Year Final Research Report

• Project/Area Number: 20591637
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: TSUCHIYA Mariko 東京女子医科大学, 医学部, 准教授 (00266826)
• Co-Investigator(Renkei-kenkyūsha): TSUCHIYA Ken 東京女子医科大学, 医学部, 准教授 (00246472)
• Project Period (FY): 2008 – 2010
• Keywords: 転写因子 / インスリン / maf / siRNA / マイクロアレイ / 膵細胞

Research Abstract

Suppression of mafA mRNA with siRNA prevents adipose cell differentiation in 3T3-L1 cells, which suggests a possible role of the transcription factor mafA in regulation of adipocyte function and differentiation. MafA is a key molecule in glucose and energy balance in the central nervous system and peripheral organs, and mafA is likely involved in the regulation of hormonal systems related to glucose metabolism.

Research Products

• [Journal Article] Kosaku Nitta and Atsushi Maeda MafA is a key molecule in glucose and energy balance in the central nervous system and peripheral organs (2011)
  • Author(s): Mariko Tsuchiya, Ken Tsuchiya, Kazuki Yasuda, Mikiko Fujita, Akira Takinishi, Maiko Furukawa
  • Journal Title: Int. J. Biomed. Sci. Volume: 7(1) Pages: 19-26
• [Journal Article] Supression of MafA mRNA with siRNA prevents adipose cell differentiation in 3T3-L1 cells (2009)
  • Author(s): Mariko Tsuchiya, Atsushi Maeda, Ayume Suzuki, Kazuki Yasuda, Takumi Yoshida, Kosaku Nitta and Ken Tsuchiya
  • Journal Title: Int. J. Mol. Med. Volume: 23 Pages: 725-732
• [Presentation] Transcription factor mafB and a functional link to E-cadherin expression in b cell differentiation (2011)
  • Author(s): Mariko Tsuchiya, Ken Tsuchiya, Kosaku Nitta, Atsushi Maeda
  • Organizer: 71st scientific sessions of American Diabetes Association
  • Place of Presentation: San Diego, CA
  • Year and Date: 20110624-28
• [Presentation] Transcription factor mafB is implicated in regulation of expression of lipocalin2 and EMT-related genes as well as genes composing of developing pancreas (2010)
  • Author(s): Mariko Tsuchiya, Atsushi Maeda, Kosaku Nitta, Ken Tsuchiya
  • Organizer: 70^<th> scientific session of American Diabetic Association
  • Place of Presentation: Orland, FL
  • Year and Date: 20100625-29
• [Presentation] Functional role of transcription factor of mafB in vivo assessed by siRNA techinique and microarray analysis (2009)
  • Author(s): Mariko Tsuchiya, Ayume Suzuki, Akiko Hayashi, Junko Tanaka, Ken Tsuchiya Atsushi Maeda
  • Place of Presentation: Viena
  • Year and Date: 20090929-1002
• [Presentation] MafA is a key molecule in glucose and energy balance in the central nervous system as in the peripheral organs (2009)
  • Author(s): Mariko Tsuchiya, Ken Tsuchiya, Kazuki Yasuda, Ayume Suzuki, Atsushi Maeda
  • Organizer: 69^<th> scientific sessions of American Diabetic Association
  • Place of Presentation: New Orleans, LA
  • Year and Date: 20090605-09
• [Presentation] Supression of mafA mRNA attenuates morphology and functions of adipocyte differentiation by 3T3-L1 cells (2008)
  • Author(s): Mariko Tsuchiya, Atsushi Maeda, Kazuki Yasuda, Ken Tsuchiya
  • Organizer: 68^<th> scientific sessions of American Diabetic Association
  • Place of Presentation: San Francisco, CA
  • Year and Date: 20080606-10