2010 Fiscal Year Final Research Report
Protective effects of cold spinoplegia with fasudi I against ischemic spinal cord injury in rabbits
| Project/Area Number |
20591650
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
NAKASHIMA Atsuhiro Kyushu University, 九州大学病院, 助教 (10260704)
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| Co-Investigator(Kenkyū-buntansha) |
TANOUE Yoshihisa 九州大学, 病院, 助教 (40372742)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 脊髄虚血 / rho-kinase inhibitor / 虚血再潅流障害 / spiuoplegia |
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| Research Abstract |
This study has revealed that fasudil has a neuroprotective effect against ischemic spinal cord injury in rabbits. Inhibition of the Rho/Rho kinase pathway by fasudil reduces the number of infiltrating cells in the ventral horn and prolongs the expression of eNOS. In the near future, ROCK may be an important therapeutic target for paraplegia induced by spinal cord ischemia.
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