2010 Fiscal Year Final Research Report

Direct delivery of vascular endothelial growth factor improves heart failure in rats' myocardial infarction model.

Research Project

Project/Area Number	20591655
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Thoracic surgery
Research Institution	Wakayama Medical University
Principal Investigator	TOGUCHI Koji Wakayama Medical University, 医学部, 助教 (20549753)
Co-Investigator(Kenkyū-buntansha)	KANEKO Masahiro 和歌山県立医科大学, 医学部, 学内助教 (40433346) HIRAMATSU Takeshi 和歌山県立医科大学, 医学部, 講師 (70221520) OKAMURA Yoshitaka 和歌山県立医科大学, 医学部, 教授 (80245076) MAEDA Masanobu 和歌山県立医科大学, 医学部, 教授 (80181593) WAKI Hidefumi 和歌山県立医科大学, 医学部, 講師 (50274957) KOHSAKA Akira 和歌山県立医科大学, 医学部, 講師 (00458051) NISHIMURA Yoshiharu 和歌山県立医科大学, 医学部, 講師 (70254539) HATADA Atsutoshi 和歌山県立医科大学, 医学部, 助教 (70508027)
Project Period (FY)	2008 – 2010
Keywords	急性心筋梗塞 / 血管内皮増殖因子 / 心不全 / タンパク質導入 / タンパク質治療
Research Abstract	It was successful that direct delivery of vascular endothelial growth factor(VEGF) into myocardium in acute myocardial infarction rat model. The direct delivery of VEGF reduced the size of infarcted area in acute phase after acute myocardial infarction. And then the direct delivery of VEGF improved cardiac function.