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2010 Fiscal Year Final Research Report

The prophylactic effect of pulmonary vein isolation on the occurrence of atrial fibrillation in a left atrial volume load canine model

Research Project

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Project/Area Number 20591660
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionNippon Medical School

Principal Investigator

NITTA Takashi  Nippon Medical School, 医学部, 教授 (40256954)

Co-Investigator(Kenkyū-buntansha) ISGI Yosuke  日本医科大学, 医学部, 講師 (10307895)
OMORI Hiroya  日本医科大学, 医学部, 助教 (40343587)
SAKAMOTO Shun-Ichiro  日本医科大学, 医学部, 助教 (50398872)
Project Period (FY) 2008 – 2010
Keywords心房細動 / 肺静脈 / 容量負荷
Research Abstract

To test if prophylactic pulmonary vein isolation prevents development of atrial fibrillation, the left atrial antrum circular ablation was performed by a bipolar radiofrequency ablation device in a subclavian artery - pulmonary artery canine model. The left atrial dimension was progressively increased. The atrial activation cycles were progressively shortened, particularly in the left atrium. During atrial fibrillation, focal rapid activations were observed at the superior pulmonary veins. These activations were blocked by the pulmonary vein isolation.

  • Research Products

    (47 results)

All 2010 2009 2008 Other

All Journal Article (9 results) (of which Peer Reviewed: 8 results) Presentation (29 results) Book (7 results) Remarks (2 results)

  • [Journal Article] Serial Changes in Epicardial Electrograms During and After a Coronary Artery Occlusion.2010

    • Author(s)
      Fujimatsu T, Nitta T, Osawa H, Shimizu K
    • Journal Title

      General Thoracic and Cardiovascular Surgery. 58巻

      Pages: 323-330

    • Peer Reviewed
  • [Journal Article] Surgical ablation for atrial fibrillation in cardiac surgery.2010

    • Author(s)
      Ad N, Cheng DC, Martin J, Berglin EE, Chang BC, Doukas G, Gammie JS, Nitta T, Wolf RK, Puskas JD
    • Journal Title

      Innovations. 5巻

      Pages: 74-83

    • Peer Reviewed
  • [Journal Article] Surgical ablation for atrial fibrillation in cardiac surgery : Ameta-analysis and systematic review.2010

    • Author(s)
      Cheng DC, Ad N, Martin J, Berglin EE, Chang BC, Doukas G, Gammie JS, Nitta T, Wolf RK, Puskas JD
    • Journal Title

      Innovations. 5巻

      Pages: 84-96

    • Peer Reviewed
  • [Journal Article] Efficacy of a novel bipolar radiofrequency ablation device on the beating heart for atrial fibrillation ablation : a long-term porcine study.2010

    • Author(s)
      Voeller RK, Zierer A, Lall SC, Sakamoto S, Schuessler RB, Damiano RJ Jr
    • Journal Title

      J Thorac Cardiovasc Surg. 140巻

      Pages: 203-8

    • Peer Reviewed
  • [Journal Article] Vagal denervation and reinnervation after ablation of ganglionated plexi.2010

    • Author(s)
      Sakamoto S, Schuessler RB, Lee AM, Aziz A, Lall SC, Damiano RJ Jr
    • Journal Title

      J Thorac Cardiovasc Surg. 139巻

      Pages: 444-52

    • Peer Reviewed
  • [Journal Article] Electrophysiological and Histological Assessment of Transmurality after Epicardial Ablation Using Unipolar Radiofrequency Energy.2009

    • Author(s)
      Miyagi Y, Ishii Y, Nitta T, Ochi M, Shimizu M
    • Journal Title

      J Card Surg. 24巻

      Pages: 34-40

    • Peer Reviewed
  • [Journal Article] A less invasive examination for atrial tachycardias after surgery for congenital heart disease.2009

    • Author(s)
      新田隆
    • Journal Title

      Circ J. 73巻

      Pages: 430-431

    • Peer Reviewed
  • [Journal Article] 外科用アブレーションデバイスを用いた新しい心房細動手術2009

    • Author(s)
      石井庸介,新田隆
    • Journal Title

      最新医学 64巻

      Pages: 1716-1721

  • [Journal Article] Intraoperative verification of conduction block in atrial fibrillation surgery2008

    • Author(s)
      Ishii Y, Nitta T, Kambe M, Kurita J, Ochi M, Miyauchi Y, Shimizu K
    • Journal Title

      J Thorac Cardiovasc Surg. 136巻

      Pages: 998-1004

    • Peer Reviewed
  • [Presentation] Hybrid Therapy for Chronic AF2010

    • Author(s)
      新田隆
    • Organizer
      Third Annual Meeting of Asia-Pacific Heart Rhythm Society
    • Place of Presentation
      Korea
    • Year and Date
      20101000
  • [Presentation] Full-Maze手術のすべての切開線は必要か2010

    • Author(s)
      石井庸介
    • Organizer
      第25回日本不整脈学会
    • Place of Presentation
      名古屋
    • Year and Date
      20100600
  • [Presentation] Maze for selected patients2010

    • Author(s)
      新田隆
    • Organizer
      第40回日本心臓血管外科学会
    • Place of Presentation
      神戸
    • Year and Date
      20100200
  • [Presentation] 心房細動手術のコツと落とし穴2009

    • Author(s)
      新田隆
    • Organizer
      第19回東北心臓血管外科手術手技研究会
    • Place of Presentation
      仙台
    • Year and Date
      20091100
  • [Presentation] 心房細動の外科治療2009

    • Author(s)
      新田隆
    • Organizer
      第11回京滋心臓血管外科セミナー
    • Place of Presentation
      京都
    • Year and Date
      20091000
  • [Presentation] AF surgery concomitant to other cardiac procedures, 22009

    • Author(s)
      新田隆
    • Organizer
      Asia Pacific Heart Rhythm Association
    • Place of Presentation
      Beijing, China
    • Year and Date
      20091000
  • [Presentation] 512チャンネル多点同時3次元マッピングシステム2009

    • Author(s)
      坂本俊一郎
    • Organizer
      第57回日本心臓病学会
    • Year and Date
      20090900
  • [Presentation] 心房細動の外科治療2009

    • Author(s)
      新田隆
    • Organizer
      第12回北海道心臓の会
    • Place of Presentation
      札幌
    • Year and Date
      20090900
  • [Presentation] 外科用アブレーションデバイスを用いた心房細動手術-その利点と使用上の注意点2009

    • Author(s)
      石井庸介
    • Organizer
      第24回日本不整脈学会
    • Place of Presentation
      国
    • Year and Date
      20090700
  • [Presentation] 心房細動手術の最近の動向2009

    • Author(s)
      新田隆
    • Organizer
      第9回湘南アブレーション・コミッティー
    • Place of Presentation
      葉山
    • Year and Date
      20090700
  • [Presentation] 心房細動手術2009

    • Author(s)
      新田隆
    • Organizer
      第20回関西心臓外科手術手技研究会
    • Place of Presentation
      大阪
    • Year and Date
      20090700
  • [Presentation] 心房細動の外科治療2009

    • Author(s)
      新田隆
    • Organizer
      第14回小杉循環器FORUM
    • Place of Presentation
      神奈川
    • Year and Date
      20090600
  • [Presentation] 心房細動手術後の不整脈に対する周術期対策2009

    • Author(s)
      新田隆
    • Organizer
      兵庫医科大学特別講演会
    • Place of Presentation
      大阪
    • Year and Date
      20090600
  • [Presentation] 心房細動手術のコツと落とし穴2009

    • Author(s)
      新田隆
    • Organizer
      信州大学講演会
    • Place of Presentation
      松本
    • Year and Date
      20090400
  • [Presentation] Intraoperative Verification of Conduction Block in AF surgery2009

    • Author(s)
      新田隆
    • Organizer
      第5回Five-Continent International Symposium on Cardiovascular Disease
    • Place of Presentation
      Beijing, China
    • Year and Date
      20090400
  • [Presentation] アブレーションラインにおける伝導ブロックの検証2009

    • Author(s)
      石井庸介
    • Organizer
      第39回日本心臓血管外科学会総会
    • Year and Date
      20090400
  • [Presentation] 心房細動手術の最近の動向2009

    • Author(s)
      新田隆
    • Organizer
      第4回福岡冠疾患内科外科ジョイントフォーラム
    • Place of Presentation
      福岡
    • Year and Date
      20090200
  • [Presentation] 心臓手術後心房細動の機序と治療2008

    • Author(s)
      新田隆
    • Organizer
      第3回心臓外科cutting edge forum
    • Place of Presentation
      名古屋
    • Year and Date
      20081100
  • [Presentation] Intraoperative verification of conduction block in AF surgery2008

    • Author(s)
      新田隆
    • Organizer
      ISMICS Winter Seminar 2008
    • Place of Presentation
      沖縄
    • Year and Date
      20081100
  • [Presentation] Intraoperative verification of conduction block in AF surgery2008

    • Author(s)
      新田隆
    • Organizer
      First Asia-pacific Heart Rhythm Society
    • Place of Presentation
      Singapore
    • Year and Date
      20081100
  • [Presentation] Minimally Invasive Surgery for Lone AF-Benefits and Limitations2008

    • Author(s)
      新田隆
    • Organizer
      First Asia-pacific Heart Rhythm Society
    • Place of Presentation
      Singapore
    • Year and Date
      20081100
  • [Presentation] New Insight from Human Epicardial Mapping2008

    • Author(s)
      新田隆
    • Organizer
      First Asia-pacific Heart Rhythm Society
    • Place of Presentation
      Singapore
    • Year and Date
      20081100
  • [Presentation] 不整脈の外科治療2008

    • Author(s)
      新田隆
    • Organizer
      阪神心臓弁膜症シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      20081000
  • [Presentation] 冠静脈洞肺静脈に対する術中伝導ブロック確認の有効性-心房細動手術の成功率を上げるか2008

    • Author(s)
      井庸介
    • Organizer
      第61回日本胸部外科学会総会
    • Place of Presentation
      福岡
    • Year and Date
      20081000
  • [Presentation] 心房細動の外科治療2008

    • Author(s)
      新田隆
    • Organizer
      第75回岐阜循環器疾患研究会
    • Place of Presentation
      岐阜
    • Year and Date
      20080700
  • [Presentation] 心房細動の外科治療2008

    • Author(s)
      新田隆
    • Organizer
      次世代のアブレーションデバイス講演会
    • Place of Presentation
      新潟
    • Year and Date
      20080700
  • [Presentation] 心房細動手術の落とし穴と対策2008

    • Author(s)
      新田隆
    • Organizer
      近畿心血管治療ジョイントライブ2008
    • Place of Presentation
      京都
    • Year and Date
      20080400
  • [Presentation] Map-guided Surgical Ablation2008

    • Author(s)
      新田隆
    • Organizer
      57^<th> Annual Meeting of American College of Cardiology
    • Place of Presentation
      Chicago, IL
    • Year and Date
      20080300
  • [Presentation] 不整脈外科の最先端2008

    • Author(s)
      新田隆
    • Organizer
      第18回聖路加国際病院ハートセミナー
    • Place of Presentation
      東京
    • Year and Date
      20080100
  • [Book] 循環器疾患最新の治療(2010-2011)2010

    • Author(s)
      坂本俊一郎、新田隆
    • Total Pages
      347-352
    • Publisher
      南江堂
  • [Book] 不整脈2009(孤立性心房細動の外科治療:Protagonst)2009

    • Author(s)
      新田隆
    • Total Pages
      181-191
    • Publisher
      メディカルレビュー社
  • [Book] 循環器(最近の不整脈外科治療,Annual Review 2009)2009

    • Author(s)
      新田隆,石井庸介、坂本俊一郎
    • Total Pages
      216-223
    • Publisher
      中外医学社
  • [Book] 不整脈クリニカルプラクティス(B.非薬物療法5)外科療法)2009

    • Author(s)
      新田隆
    • Total Pages
      123-128
    • Publisher
      南江堂
  • [Book] II弁膜症の外科/冠動脈の外科(心房細動の手術,図説成人心臓外科「手術を究める」)2009

    • Author(s)
      新田隆
    • Total Pages
      94-105
    • Publisher
      メディカルビュー
  • [Book] 最新医学別冊(新しい診断と治療のABC:心房細動手術の適応と実際)2009

    • Author(s)
      新田隆,石井庸介、坂本俊一郎
    • Total Pages
      234-242
    • Publisher
      最新医学社
  • [Book] Manual of Surgical Treatment of Atrial Fibrillation(The radial procedure for atrial fibrillation : theoretical basis and clinical application.)2008

    • Author(s)
      新田隆
    • Total Pages
      113-118
    • Publisher
      Blackwell Futura
  • [Remarks] ホームページ等

    • URL

      http://hosp.nms.ac.jp/staff/904.html

  • [Remarks]

    • URL

      http://www.ctsnet.org/home/tnitta

URL: 

Published: 2012-01-26   Modified: 2015-07-22  

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