2010 Fiscal Year Final Research Report
The basic research on HIF-1-targeted cancer therapy
Project/Area Number |
20591666
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Thoracic surgery
|
Research Institution | Shiga University of Medical Science |
Principal Investigator |
TERAMOTO Koji Shiga University of Medical Science, 医学部, 助教 (10452244)
|
Project Period (FY) |
2008 – 2010
|
Keywords | 腫瘍免疫学 / 腫瘍微小環境 |
Research Abstract |
In this study, we examined the possibility that hypoxia in tumor tissues might be implicated in the immunosuppression in tumor-bearing host. Based on the data that hypoxia-inducible factor-1 (HIF-1) regulates expressions of many genes associated with tumor progression, we hypothesized that inhibition of HIF-1 in tumor tissues would augment anti-tumor immune responses. Tumor-bearing mice were administered HIF-1 inhibitor into the established tumor, and then, anti-tumor immune responses elicited in the mice were examined. As results, HIF-1 inhibition attenuated the level of TGF-beta in tumor tissues. In tumor-draining lymph nodes and spleen, the numbers of regulatory cells were decreased. In spleen, antigen-specific effector cells were increased
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