2010 Fiscal Year Final Research Report
The basic research on HIF-1-targeted cancer therapy
| Project/Area Number |
20591666
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
TERAMOTO Koji Shiga University of Medical Science, 医学部, 助教 (10452244)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 腫瘍免疫学 / 腫瘍微小環境 |
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| Research Abstract |
In this study, we examined the possibility that hypoxia in tumor tissues might be implicated in the immunosuppression in tumor-bearing host. Based on the data that hypoxia-inducible factor-1 (HIF-1) regulates expressions of many genes associated with tumor progression, we hypothesized that inhibition of HIF-1 in tumor tissues would augment anti-tumor immune responses. Tumor-bearing mice were administered HIF-1 inhibitor into the established tumor, and then, anti-tumor immune responses elicited in the mice were examined. As results, HIF-1 inhibition attenuated the level of TGF-beta in tumor tissues. In tumor-draining lymph nodes and spleen, the numbers of regulatory cells were decreased. In spleen, antigen-specific effector cells were increased
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