Basic research for evaluating the donor lung mechanical properties using FOT (Forced Oscillation Technique)

2010 Fiscal Year Final Research Report

• Project/Area Number: 20591667
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Kyoto University
• Principal Investigator: SAKAI Hiroaki Kyoto University, 医学研究科, 講師 (50362489)
• Co-Investigator(Kenkyū-buntansha): DATE Hiroshi 京都大学, 医学研究科, 教授 (60252962) ; FUJINAGA Takuji 京都大学, 医学研究科, 助教 (00444456) ; ZHAO Koutou 京都大学, 大学院・医学研究科, 助教 (00444464)
• Project Period (FY): 2008 – 2010
• Keywords: FOT / lung mechanical property

Research Abstract

The forced oscillation technique (FOT) was a method to characterize respiratory impedance. Recently, FOT has been applied in both human subjects and animal models of lung disease. The main advantages of FOT are its noninvasiveness with minimal subject cooperation, and its potential ability to reflect the magnitude and distribution of airway and tissue diseases from frequency-dependent features of parameters. We applied this method to evaluate the mechanical properties of the cold storage rat lung and reported the results. We also reported case that the possibility of early detection of acute rejection after lung transplantation using FOT in humans. However the relationship between histopathology and respiratory impedance spectra has not been studied. In the next step we are planning to evaluate the sensitivity and specificity of the lung impedance (ZL) parameters, in identifying the relationship between histopathological AR grade and lung mechanics in a rat lung transplantation model. We considered that inferring structure from function is described the goal of medical diagnosis.

Research Products

• [Journal Article] Inhibitory effects of simvastatin on platelet-derived growth factor signaling in pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension. (2010)
  • Author(s): Ikeda T, Nakamura K, Akagi S, Kusano KF, Matsubara H, Fujio H, Ogawa A, Miura A, Miura D, Oto T, Yamanaka R, Otsuka F, Date H, Ohe T, Ito H.
  • Journal Title: J Cardiovasc Pharmacol 55(1) Pages: 39-48
  • Peer Reviewed
• [Journal Article] Living-donor single-lobe lung transplant in a 6-year-old girl after 7-month mechanical ventilator support. (2010)
  • Author(s): Shoji T, Bando T, Fujinaga T, Date H.
  • Journal Title: J Thorac Cardiovasc Surg 139(5) Pages: e112-3
  • Peer Reviewed
• [Journal Article] Forced oscillation technique as a non-invasive assessment for lung transplant recipients. (2010)
  • Author(s): 3) Hamakawa H, Sakai H, Takahashi A, Zhang J, Okamoto T, Satoda N, Aoyama A, Chen F, Fujinaga T, Shoji T, Bando T, Mishima M, Wada H, Date H.
  • Journal Title: Adv Exo Ned Biol 662 Pages: 293-8
  • Peer Reviewed
• [Journal Article] Living-donor lobar lung transplantation for interstitial pneumonia associated with dermatomyositis. (2010)
  • Author(s): Shoji T, Bando T, Fujinaga T, Okubo K, Yukawa N, Mimori T, Date H.
  • Journal Title: Transplant Int 23(5) Pages: e10-1
  • Peer Reviewed
• [Journal Article] Post-transplant lymphoproliferative disorder following cytomegalovirus reactivation in a lung recipient. (2010)
  • Author(s): Aoyama A, Omasa M, Kondo N, Chen F, Date H, Bando T.
  • Journal Title: Gen Thorac Cardiovasc Surg 58(5) Pages: 251-4
  • Peer Reviewed
• [Journal Article] Perioperative assessment of oversized lobar graft downsizing in living-donor lobar lung transplantation using three-dimensional computed tomographic volumetry. (2010)
  • Author(s): Chen F, Fujinaga T, Shoji T, Yamada T, Nakajima D, Sakamoto J, Sakai H, Bando T, Date H.
  • Journal Title: Transplant Int 23(9) Pages: e41-4
  • Peer Reviewed
• [Journal Article] Repeat resection of pulmonary metastasis is beneficial for patients with colorectal carcinoma. (2010)
  • Author(s): Chen F, Sakai H, Miyahara R, Bando T, Okubo K, Date H.
  • Journal Title: World J Surg 34(19) Pages: 2373-8
  • Peer Reviewed
• [Journal Article] Establishment of an ex vivo lung perfusion model using non-heart-beating large pigs. (2010)
  • Author(s): Okamoto T, Chen F, Zhang J, Yamada T, Nakayama E, Morikawa H, Bando T, Date H.
  • Journal Title: Transplant Proc 42(5) Pages: 1598-601
  • Peer Reviewed
• [Journal Article] Right ventricular outflow tract obstruction after bilateral lung trnsplantation. (2009)
  • Author(s): Chen F, Hanaoka N, Hasegawa S, Fujinaga T, Shoji T, Sakai H, Bando T
  • Journal Title: Thorac Cardiovasc Surg(Epub 2009 Jan 23) 57(1) Pages: 48-50
  • Peer Reviewed
• [Journal Article] Nebulized phosphodiesterase III inhibitor during warm ischemia attenuates pulmonary ischemia-reperfusion injury. (2009)
  • Author(s): Zhang J, Chen F, Zhao X, Aoyama A, Okamoto T, Fujinaga T, Shoji T, Sakai H, Cui Y, Bando T, Date H
  • Journal Title: J Heart Lung Transplant 28(1) Pages: 79-84
  • Peer Reviewed
• [Journal Article] Body mass index in male patients with COPD : correlation with low attenuation areas on CT. (2009)
  • Author(s): Ogawa E, Nakano Y, Ohara T, Muro S, Hirai T, Sato S, Sakai H, Tsukino M, Kinose D, Nishioka M, Niimi A, Chin K, Pare PD, Mishima M.
  • Journal Title: Thorax. 64(1) Pages: 20-5
  • Peer Reviewed
• [Journal Article] A follow-up report on a new method of segmental resection for small-sized early lung cancer. (2009)
  • Author(s): Bando T, Miyahara R, Sakai H, Shoji T, Sonobe M, Sato K, Fujinaga T, Chen F, Okubo K, Hirata T, Wada H
  • Journal Title: Lung Cancer. 63(1) Pages: 58-62
  • Peer Reviewed
• [Journal Article] Sirolimus treatment for recurrent lymphangioleiomyomatosis after lung transplantation. (2009)
  • Author(s): Chen F, Omasa M, Kondo N, Fujinaga T, Shoji T, Sakai H, Bando T
  • Journal Title: Ann Thorac Surg 87(1) Pages: e6-7
  • Peer Reviewed
• [Journal Article] Sternal wound dehiscence after transverse thoracosternotomy for bilateral lung transplantation: report of a case. (2008)
  • Author(s): Chen F, Aoyama A, Kondo N, Fujinaga T, Shoji T, Omasa M, Sakai H, Bando T
  • Journal Title: Surg Today 38 Pages: 942-4
  • Peer Reviewed
• [Journal Article] Pulmonary resection for metastatic head and neck cancers. (2008)
  • Author(s): Chen F, Sonobe M, Sato K, Fujinaga T, Shoji T, Sakai H, Miyahara R, Bando T, Okubo K, Hirata T, Date H
  • Journal Title: World J Surg 32 Pages: 1657-62
  • Peer Reviewed
• [Journal Article] Pulmonary resection for metastases from hepatocellular carcinoma. (2008)
  • Author(s): Chen F, Sato K, Fujinaga T, Sonobe M, Shoji T, Sakai H, Miyahara R, Bando T, Okubo K, Hirata T, Date H
  • Journal Title: World J Surg 32 Pages: 2213-7
  • Peer Reviewed
• [Journal Article] Pulmonary resection for metastasis from esophageal carcinoma. (2008)
  • Author(s): Chen F, Sato K, Sakai H, Miyahara R, Bando T, Okubo K, Hirata T, Date H
  • Journal Title: Interact Cardiovasc Thorac Surg 7 Pages: 809-12
  • Peer Reviewed
• [Journal Article] Value of Foxp3 expression in peripheral blood as rejection marker after miniature swine lung transplantation. (2008)
  • Author(s): Satoda N, Shoji T, Wu Y, Fuijnaga T, Chen F, Aoyama A, Zhang JT, Takahashi A, Okamoto T, Matsumoto I, Sakai H, Li Y, Zhao X, Manabe T, Kobayashi E, Sakaguchi S, Wada H, Uemoto S, Tottori J, Bando T, Date H, Koshiba T
  • Journal Title: J Heart Lung Transplant 27(12) Pages: 1293-301
  • Peer Reviewed
• [Journal Article] Successful subzero nonfreezing preservation of rat lungs at -2C utilizing a new supercooling technology. (2008)
  • Author(s): Okamoto T, Nakamura T, Zhang J, Aoyama A, Chen F, Fujinaga T, Shoji T, Hamakawa H, Sakai H, Manabe T, Wada H, Date H, Bando T
  • Journal Title: J Heart Lung Transplant. 27(10) Pages: 1150-7
  • Peer Reviewed
• [Presentation] Peripheral airway heterogeneity of the rat lung after cold preservation : assessment using forced oscillation technique (2009)
  • Author(s): H.Sakai
  • Organizer: ACTSA
  • Place of Presentation: Seoul
  • Year and Date: 2009-10-25
• [Presentation] Date Dynamic Instabilities in Perfused Rat Lungs with Cold Preservation Solutions (2008)
  • Author(s): H.Hamakawa, H.Sakai, J.Zhang, F.Chen, A.Aoyama, T.Fujinaga, T.Shoji, T.Bando, H.Wada, H.
  • Organizer: ATS
  • Place of Presentation: Thematic Poster Session, USA
  • Year and Date: 2008-05-21
• [Presentation] Evaluation of Lung Mechanics in Acute Lung Allograft Rejection in Rats, Using Forced Oscillation Technique (FOT) (2008)
  • Author(s): A.Takahashi, H.Sakai, X.Zhao, M.D., H.Hamakawa, T.Okamoto, N. Satoda, A. Aoyama, J. Zhang, F. Chen, T. Fujinaga, T. Shoji, T. Bando, H. Wada, H. Date
  • Organizer: ATS
  • Place of Presentation: Poster Discussion Session, USA
  • Year and Date: 2008-05-19
• [Presentation] Evaluation of lung mechanics on acute allograft rejection in a rat single lung transplant model using forced oscillation technique (FOT) ERS Vienna 2009 Congress (2008)
  • Author(s): A.Takahashi, H.Sakai, Zhao X, H.Date, et al
  • Organizer: New Surgical Approach for COPD : Covering Lung with an Elastic Net ATS.(T.Sato, H.Sakai, A.Takahashi, H.Date, T.Nakamura)
  • Place of Presentation: Mini-Symposium, Vienna
  • Year and Date: 2008-05-18
• [Presentation] New Surgical Approach for COPD : Covering Lung with an Elastic Net (2008)
  • Author(s): T.Sato, H.Sakai, A.Takahashi, H.Date, T.Nakamura
  • Organizer: ATS
  • Place of Presentation: Mini-Symposium, USA
  • Year and Date: 2008-05-18
• [Presentation] Chest Subcutaneous Fat Mass Measured by Chest Computed Tomography Correlated with Low Attenuation Areas in COPD (2008)
  • Author(s): E.Ogawa, T.Ohara, D.Kinose, M.D., M.Nishioka., H.Sakai, S.Muro, T.Hirai, Y.Nakano, M.Mishima
  • Organizer: ATS
  • Place of Presentation: Poster Discussion USA
  • Year and Date: 2008-05-18
• [Book] 呼吸器外科領域「重症心不全の治療:補助循環・人工心臓・再生医療の実際 (2010)
  • Author(s): 阪井宏彰, 伊達洋至
  • Total Pages: 128-133
  • Publisher: 秀潤社
• [Book] Living donor lobar lung transplantation.(In: Hakim N, Canelo R, Papalois V, eds.)(Living Related Transplantation.) (2010)
  • Author(s): Date H, Shimizu N
  • Total Pages: 143-61
  • Publisher: London : Imperial College Press
• [Book] 肺高血圧症と肺移植(山口徹・高本眞一・小室一成・佐地勉(編))(Annual Review循環器) (2010)
  • Author(s): 伊達洋至
  • Total Pages: 245-8
  • Publisher: 中外医学社
• [Book] 縦隔および横隔膜(北島政樹(監)加藤治文・畠山勝義・北野正剛(編))(標準外科学第12版) (2010)
  • Author(s): 伊達洋至
  • Total Pages: 434-42
  • Publisher: 医学書院
• [Book] Diagnostic strategies for mediastinal tumors and cysts.(In: Venuta F ed. Thoracic Surgery Clinics. Diseases of the mediastinum.) (2009)
  • Author(s): 伊達洋至
  • Total Pages: 29-35
  • Publisher: Philadelpia : WB Saunders Company
• [Book] 肺移植、松岡健(編)呼吸器疾患ガイドライン-最新の診療指針-. (2009)
  • Author(s): 伊達洋至
  • Total Pages: 318-20
  • Publisher: 総合医学社
• [Book] 肺気腫に対するlung volume reduction surgery (LVRS)(正岡昭・藤井義敬(編)呼吸器外科学改訂第4版) (2009)
  • Author(s): 伊達洋至
  • Total Pages: 306-9
  • Publisher: 南山堂
• [Book] エキスパートの呼吸管理(岡元和文(編)肺移植前後の呼吸管理) (2008)
  • Author(s): 山根正修、伊達洋至
  • Total Pages: 478-82
  • Publisher: 中外医学社
• [Book] 新しい診断と治療のABC.特発性肺線維症(泉孝英(編)外科療法・肺移植) (2008)
  • Author(s): 伊達洋至
  • Total Pages: 147-53
  • Publisher: 最新医学社
• [Book] 生体侵襲と臓器管理(松田直之(編)肺移植手術の生体侵襲) (2008)
  • Author(s): 伊達洋至
  • Total Pages: 1187-90
  • Publisher: 総合医学社
• [Remarks] ホームページ等
  • URL: http://www.thoracic-kyoto-u.gr.jp/