2010 Fiscal Year Final Research Report
Immunological function of thymoma in terms of interaction between T cells and neoplastic epithelial cells
| Project/Area Number |
20591669
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Osaka University |
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Principal Investigator |
KADOTA Yosihisa Osaka University, 医学系研究科, 助教 (50464243)
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| Co-Investigator(Kenkyū-buntansha) |
OKUMURA Meinosin 大阪大学, 医学系研究科, 教授 (40252647)
INOUE Masayosi 大阪大学, 医学系研究科, 講師 (10379232)
MINAMI Masato 大阪大学, 医学部附属病院, 准教授 (10240847)
UTUMI Tomoki 大阪大学, 医学系研究科, 助教 (40423165)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 胸腺腫 / 重症筋無力症 / 胸腺微小環境 / TH-POK / AIRE |
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| Research Abstract |
Thymoma is known to associate with autoimmune diseases. Thymoma derived T cells were thought plausible to investigate the pathogenesis of thymoma associated autoimmunity. In this study we investigate the development of thymoma T cell in terms of its lineage-commitment and its exportation to the peripheral blood. Our results suggested that Th-POK and Runx3 expression of T cell in thymoma could have key roles in the lineage commitment.
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