2010 Fiscal Year Final Research Report
Tumor cell spread during lung cancer operation and postoperative distant metastasis.
| Project/Area Number |
20591679
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Hyogo College of Medicine |
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Principal Investigator |
HASEGAWA Seiki Hyogo College of Medicine, 医学部, 教授 (10252438)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Fumihiro 産業医科大学, 医学部, 教授 (10283673)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 肺癌 / 循環腫瘍細胞 / 肺静脈 / 遠隔転移 |
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| Research Abstract |
One possible explanation for postoperative recurrence of lung cancer is intraoperative tumor cell spread. To verify the above hypothesis, we measured circulating tumor cell (CTC) count in both preoperative peripheral venous blood and also pulmonary venous blood of the extracted lobe by CellSearchTM system. CTC was detected in peripheral blood in 5 patients (16.7% ; the periCTC-count, 1 in 2 patients and 2, 3, 16 in one patient each), and the incidence was higher in squamous cell carcinoma patients than in adenocarcinoma patients (p=0.028). CTC was detected in pulmonary venous blood in most patients (29/30, 96.7%), and the mean and median CTC-counts were 1195 and 81, respectively (range, 0-10034). There was no significant correlation between CTC-count in peripheral blood and in pulmonary venous blood.
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