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2010 Fiscal Year Final Research Report

Clinical application and the validation of 3T-MRI based multi-tensor fiber tractography

Research Project

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Project/Area Number 20591685
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionOsaka University

Principal Investigator

HASHIMOTO Naoya  Osaka University, 大学院・医学系研究科, 准教授 (90315945)

Co-Investigator(Kenkyū-buntansha) YAMADA Kei  京都府立医科大学, 医学系研究科, 講師 (80315960)
YOSHIMINE Toshiki  大阪大学, 大学院・医学系研究科, 教授 (00201046)
Project Period (FY) 2008 – 2010
Keywords3T-MRI / 拡散テンソル / マルチテンソル / トラクトグラフィー / 電気生理学的検証
Research Abstract

A novel approach of fiber tractography named "multi-tensor tractography (MT)" was applied to 3T-MRI based DTI and successfully used in neurosurgery to improve the accuracy of neuro-navigational system. Then, MT mounted on the system has been validated by intra-operative electrophysiological monitoring and mapping.

  • Research Products

    (40 results)

All 2011 2010 2009 2008 Other

All Journal Article (17 results) (of which Peer Reviewed: 17 results) Presentation (21 results) Book (2 results)

  • [Journal Article] Diffusion tensor based tumor infiltration index cannot discriminate vasogenic edema from tumor-infiltrated edema.2010

    • Author(s)
      Kinoshita M, Goto T, Okita Y, Kagawa N, Kishima H, Hashimoto N, Yoshimine T
    • Journal Title

      Neuro-oncol 96

      Pages: 409-415

    • Peer Reviewed
  • [Journal Article] 11C-methionine uptake correlates with tumor cell density rather than with microvessel density in glioma : a stereotactic image-histology comparison.2010

    • Author(s)
      Okita Y, Kinoshita M, Goto T, Kagawa N, Kishima H, Shimosegawa E, Hatazawa J, Hashimoto N, Yoshimine T
    • Journal Title

      Neuroimage 49

      Pages: 2977-2982

    • Peer Reviewed
  • [Journal Article] A surgically treated case of Lhermitte-Duclos disease with a precise natural history and high uptake of FDG on PET.2010

    • Author(s)
      Goto Y, Hashimoto N, Okita Y, Goto T, Rabo C, Hirayama H, Horikawa Y, Kinoshita M, Kagawa N, Yoshimine T
    • Journal Title

      J Neuro-oncol 97

      Pages: 445-450

    • Peer Reviewed
  • [Journal Article] MR molecular imaging of HER-2 in a murine tumor xenograft by SPIO labeling of anti-HER-2 affibody.2010

    • Author(s)
      Kinoshita M, Yoshioka Y, Okita Y, Hashimoto N, Yoshimine T
    • Journal Title

      Contrast Media Mol Imaging 5

      Pages: 18-22

    • Peer Reviewed
  • [Journal Article] MR Imaging of Ventral Thalamic Nuclei.2010

    • Author(s)
      Yamada K, Akazawa K, Yuen S, Goto M, Matsushima S, Takahata A, Nakagawa M, Mineura K, Nishimura T
    • Journal Title

      AJNR Am J Neuroradiol 31

      Pages: 732-735

    • Peer Reviewed
  • [Journal Article] Cerebral white matter lesions may be partially reversible in patients with carotid artery stenosis.2010

    • Author(s)
      Yamada K, Sakai K, Owada K, Mineura K, Nishimura T
    • Journal Title

      AJNR Am J Neuroradiol 31

      Pages: 1350-1352

    • Peer Reviewed
  • [Journal Article] Optimum b value for resolving crossing fibers : a study with standard clinical b value using 1.5-T MR.2010

    • Author(s)
      Akazawa K, Yamada K, Matsushima S, Goto M, Yuen S, Nishimura T
    • Journal Title

      Neuroradiology 52

      Pages: 723-728

    • Peer Reviewed
  • [Journal Article] In vivo assessment of peripheral nerve regeneration by diffusion tensor imaging.2010

    • Author(s)
      Morisaki S, Kawai Y, Umeda M, Nishi M, Oda R, Fujiwara H, Yamada K, Higuchi T, Tanaka C, Kawata M, Kubo T
    • Journal Title

      J Magn Reson Imaging 31

      Pages: 535-542

    • Peer Reviewed
  • [Journal Article] Use of fractional anisotropy for determination of the cut-off value in 11C-methionine positron emission tomography for glioma.2009

    • Author(s)
      Kinoshita M, Hashimoto N, Goto T, Kagawa N, Kishima H, Izumoto S, Tanaka H, Fujita N, Yoshimine T
    • Journal Title

      Neuroimage 45

      Pages: 312-318

    • Peer Reviewed
  • [Journal Article] Serial volumetric assessmsent of the natural history and growth pattern of incidentally discovered meniniomas.2009

    • Author(s)
      Hashiba T, Hashimoto N, Izumoto S, Suzuki T, Kagawa N, Maruno M, Kato A, Yoshimine T
    • Journal Title

      Jornal of Neurosurgery 110(4)

      Pages: 675-684

    • Peer Reviewed
  • [Journal Article] Assessment of arcuate fasciculus with diffusion-tensor tractography may predict the prognosis of aphasia in patients with left middle cerebral artery infarcts.2009

    • Author(s)
      Hosomi A, Nagakane Y, Yamada K, Kuriyama N, Mizuno T, Nishimura T, Nakagawa M
    • Journal Title

      Neuroradiology 51

      Pages: 549-555

    • Peer Reviewed
  • [Journal Article] Diffusion tensor tractography should be used with caution.2009

    • Author(s)
      Yamada K
    • Journal Title

      Proc Natl Acad Sci USA 106

      Pages: E14

    • Peer Reviewed
  • [Journal Article] Diffusion tensor imaging may help the determination of time at onset in cerebral ischaemia.2009

    • Author(s)
      Sakai K, Yamada K, Nagakane Y, Mori S, Nakagawa M, Nishimura T
    • Journal Title

      J Neurol Neurosurg Psychiatry 80

      Pages: 986-990

    • Peer Reviewed
  • [Journal Article] Incidental acute infarcts identified on diffusion-weighted images : A university hospital-based study.2008

    • Author(s)
      Yamada K, Nagakane Y, Sasajima H, Nakagawa M, Mineura K, Masunami T, Akazawa K, Nishimura T
    • Journal Title

      AJNR Am J Neuroradiol 29

      Pages: 937-940

    • Peer Reviewed
  • [Journal Article] Cerebral white matter damage in frontotemporal dementia assessed by diffusion tensor tractography.2008

    • Author(s)
      Matsuo K, Mizuno T, Yamada K, Akazawa K, Kasai T, Kondo M, Mori S, Nishimura T, Nakagawa M
    • Journal Title

      Neuroradiology 50

      Pages: 605-611

    • Peer Reviewed
  • [Journal Article] Alteration of fractional anisotropy and apparent diffusion coefficient in obsessive-compulsive disorder : A diffusion tensor imaging study.2008

    • Author(s)
      Nakamae T, Narumoto J, Shibata K, Matsumoto R, Kitabayashi Y, Yoshida t, Yamada K, Nishimura T, Fukui K
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry 32

      Pages: 1221-1226

    • Peer Reviewed
  • [Journal Article] Variability in absolute apparent diffusion coefficient values across different platforms may be substantial : A multivendor, multi-institutional comparison study.2008

    • Author(s)
      Sasaki M, Yamada K, Watanabe Y, Matsui M, Ida M, Fujiwara S, Shibata E
    • Journal Title

      Radiology 249

      Pages: 624-630

    • Peer Reviewed
  • [Presentation] Novel "Subcortical" Stimulation and Detection of Sensori-visual Evoked Potentials for the Validation of Fiber-tractography.2011

    • Author(s)
      Hashimoto N, Goto T, Yamada K
    • Organizer
      The 2nd International Symposium on the Project Computational Anatomy
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2011-03-06
  • [Presentation] Anatomical Validation and Clinical Feasibility of Fiber-Tractography Based on Diffusion Tensor Imaging.2011

    • Author(s)
      Hashimoto N, Goto T, Yamada K
    • Organizer
      The 2nd International Symposium on the Project Computational Anatomy
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2011-03-06
  • [Presentation] Glucose and methionine uptake decouples in T2-hyperintese area with tumor infiltration but not in pure vasogenic edema.2010

    • Author(s)
      Kinoshita M, Goto T, Kagawa N, Fujimoto Y, Kishima H, Hatazawa J, Hashimoto N, Yoshimine T
    • Organizer
      Neuroscience 2010 -40^<th> Annual meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2010-11-16
  • [Presentation] 皮質下脳波計測による神経白質線維の活動計測.2010

    • Author(s)
      後藤哲、平田雅之、橋本直哉、貴島晴彦、柳澤琢史、齋藤洋一、佐野史郎、吉峰俊樹
    • Organizer
      第69回日本脳神経外科学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2010-10-28
  • [Presentation] 無症候性病変の手術適応と手術時期.2010

    • Author(s)
      吉峰俊樹、橋本直哉、羽柴哲夫、後藤哲、沖田典子、Rabo Carter、藤本康倫、香川尚己、木下学、山本福子、木嶋教行、有田英之
    • Organizer
      第69回日本脳神経外科学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2010-10-28
  • [Presentation] 多画像同時解析による新規画像診断法の開発:voxel-wise analysisが可能にする真のマルチモダール画像解析2010

    • Author(s)
      木下学、後藤哲、有田英之、沖田典子、香川尚己、藤本康倫、貴島晴彦、畑澤順、橋本直哉、吉峰俊樹
    • Organizer
      第69回日本脳神経外科学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2010-10-27
  • [Presentation] Affibodyを用いたMRIによるHER-2受容体の分子イメージング2010

    • Author(s)
      木下学、吉岡芳親、沖田典子、橋本直哉、吉峰俊樹
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-24
  • [Presentation] Stereotactic Image-Histology Comparison Among 11C-Methionine Uptake and Histopathology in Gliomas.2010

    • Author(s)
      沖田典子, 木下学, Goto T, 香川尚己, 木嶋教行, 橋本直哉, 吉峰俊樹
    • Organizer
      7th Meeting of Asian Society for Neuro-Oncology
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2010-06-12
  • [Presentation] MR molecular imaging of HER-2 in a murine tumor xenograft by SPIO labeling of anti-HER-2 Affibody.2010

    • Author(s)
      木下学, 吉岡芳親, 沖田典子, 橋本直哉, 吉峰俊樹
    • Organizer
      International Society for Magnetic Resonance in Medicine (ISMRM) 18th Scientific Meeting
    • Place of Presentation
      Stockholm, Sweeden
    • Year and Date
      2010-05-03
  • [Presentation] 拡散テンソル画像によるtumor infiltration indexは悪性gliomaの浸潤評価に有用か?2009

    • Author(s)
      木下学、後藤哲、沖田典子、香川尚己、貴島晴彦、橋本直哉、吉峰俊樹
    • Organizer
      第27回日本脳腫瘍学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-11-08
  • [Presentation] 悪性グリオーマにおけるモニタリングと長期成績:現状と今後の展望.2009

    • Author(s)
      橋本直哉, 木嶋教行, 千葉泰良, 沖田典子, 山本福子, 後藤哲, 平田雅之, 木下学, 香川尚己, 吉峰俊樹
    • Organizer
      第68回日本脳神経外科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-14
  • [Presentation] 言語領野近傍の手術におけるmultitensor fiber tractographyとmethioninePETとの有効利用:覚醒下手術の迅速化.2009

    • Author(s)
      橋本直哉, 木嶋教行, 千葉泰良, 沖田典子, 山本福子, 後藤哲, 平田雅之, 木下学, 香川尚己, 吉峰俊樹
    • Organizer
      第14回日本脳腫瘍の外科学会
    • Place of Presentation
      東京
    • Year and Date
      2009-09-25
  • [Presentation] Use of fractional anisotropy for determination of the cut-off value in 11C-methionine positron emission tomography for glioma.2009

    • Author(s)
      木下学, 橋本直哉, Goto T, 柳澤琢史, 香川尚己, 木嶋教行, 畑澤順, 吉峰俊樹
    • Organizer
      ISMRM 17th Annual Meeting and Exhibition
    • Place of Presentation
      Honululu, USA
    • Year and Date
      2009-04-23
  • [Presentation] 左島弁蓋部神経膠腫に対してマルチモダリティー覚醒手術を施行した一症例2009

    • Author(s)
      後藤雄子、平田雅之、後藤哲、沖田典子、山本福子、千葉泰良、木下学、香川尚己、橋本直哉、吉峰俊樹
    • Organizer
      近畿脳腫瘍研究会
    • Place of Presentation
      大阪
    • Year and Date
      2009-04-04
  • [Presentation] Use of fractional anisotropy for determination of the cut-off value in methionine PET.2009

    • Author(s)
      木下学、後藤哲、柳澤琢史、沖田典子、香川尚己、貴島晴彦、橋本直哉、吉峰俊樹
    • Organizer
      第32回日本脳神経CI学会総会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-06
  • [Presentation] 拡散テンソル画像による細胞密度、増殖能の評価とFDG-PETとの相関性2008

    • Author(s)
      木下学、沖田典子、後藤哲、山本福子、千葉泰良、香川尚己、貴島晴彦、橋本直哉、吉峰俊樹
    • Organizer
      第26回日本脳腫瘍学会
    • Place of Presentation
      松山
    • Year and Date
      2008-12-02
  • [Presentation] Multi-tensor fiber trackingのグリオーマ手術への応用2008

    • Author(s)
      橋本直哉、後藤哲、沖田典子、山本福子、千葉泰良、木下学、香川尚己、吉峰俊樹
    • Organizer
      第26回日本脳腫瘍学会
    • Place of Presentation
      松山
    • Year and Date
      2008-12-01
  • [Presentation] MRIによる脳腫瘍の生物学的特性の評価の試み?拡散テンソル画像(DTI)による細胞密度、増殖能の評価-2008

    • Author(s)
      木下学、橋本直哉、後藤哲、沖田典子、山本福子、千葉泰良、香川尚己、貴島晴彦、吉峰俊樹
    • Organizer
      第67回日本脳神経外科学会総会
    • Place of Presentation
      盛岡
    • Year and Date
      2008-10-03
  • [Presentation] 脳磁図、皮質電位、ファイバートラッキング、経頭蓋磁気刺激を用いた術前術中視覚機能評価2008

    • Author(s)
      平田雅之、橋本直哉、後藤哲、齊藤洋一、貴島晴彦、押野悟、柳澤琢史、細見晃一、依藤史郎、吉峰俊樹
    • Organizer
      第8回日本脳神経外科術中画像研究会
    • Place of Presentation
      大阪
    • Year and Date
      2008-07-26
  • [Presentation] Multi-tensor tractographと11C-methionine PETを搭載したナビゲーションシステムによる脳腫瘍の手術2008

    • Author(s)
      橋本直哉、平田雅之、沖田典子、後藤哲、山本福子、千葉泰良、木下学、香川尚己、吉峰俊樹
    • Organizer
      第8回日本脳神経外科術中画像研究会
    • Place of Presentation
      大阪
    • Year and Date
      2008-07-26
  • [Presentation] 無症候性髄膜腫の自然経過:体積計測による個別未来予測2008

    • Author(s)
      橋本直哉、羽柴哲夫、後藤哲、沖田典子、山本福子、千葉泰良、木下学、香川尚己、吉峰俊樹
    • Organizer
      第17回日本脳ドック学会総会
    • Place of Presentation
      郡山
    • Year and Date
      2008-06-28
  • [Book] 脳磁図、皮質の脳波、ファイバートラキング、経頭蓋磁気刺激を用いた術前・術中視覚機能評価2009

    • Author(s)
      平田雅之、後藤哲、谷直樹、甲津彩子、元木優、齋藤洋一、貴島晴彦、橋本直哉、柳澤琢史、細見晃一、依藤史郎、吉峰俊樹
    • Total Pages
      721-728
    • Publisher
      臨床脳波 51
  • [Book] Incidentally discovered meningiomas : growth rates and patterns. Tumors of the Central Nervous System.

    • Author(s)
      橋本直哉, 吉峰俊樹
    • Publisher
      Springer (New York)(in press)

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Published: 2012-01-26   Modified: 2016-04-21  

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