• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2010 Fiscal Year Final Research Report

The effects of bone marrow derived macrophages on ischemic brain damage

Research Project

  • PDF
Project/Area Number 20591688
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionEhime University

Principal Investigator

HATA Ryuji  Ehime University, 大学院・医学系研究科, 准教授 (90258153)

Co-Investigator(Kenkyū-buntansha) ONISHI Takanori  愛媛大学, 大学院・医学系研究科, 教授 (70233210)
KUMON Yoshiaki  愛媛大学, 大学院・医学系研究科, 准教授 (80127894)
DEZAKI Junzo  愛媛大学, 大学院・医学系研究科, 講師 (00036451)
Project Period (FY) 2008 – 2010
Keywords脳虚血 / 自然免疫 / TLR4(Toll like receptor 4) / マイクログリア
Research Abstract

Cerebral ischemia triggers acute inflammation, which exacerbates primary brain damage. Activation of the innate immune system is an important component of this inflammatory response. Inflammation occurs through the action of proinflammatory cytokines. Production of these cytokines is initiated by signaling through Toll-like receptors (TLRs). Among them, TLR4 recognizes primarily lipopolysaccharide (LPS) and an increasing evidence points that TLR4 plays a crucial role in the concert mechanism of the cerebra ischemia. In this study, we investigated the effect of targeted disruption of TLR4 on the severity of ischemic brain injury. TLR4 ablation significantly decreased infarct size at 1 day after reperfusion. The amelioration of tissue damage in the absence of TLR4 underscores the importance of innate immunity for the manifestation of ischemic brain injury. Furthermore, TLR4 ablation in the bone marrow derived macrophage significantly decreased infarct size. These results indicate that bone barrow derived macrophages are an important modulator of ischemic brain injury.

  • Research Products

    (24 results)

All 2011 2010 2009 2008 Other

All Journal Article (23 results) (of which Peer Reviewed: 23 results) Remarks (1 results)

  • [Journal Article] Reduced ischemic brain injury by partial rejuvenation of bone marrow cells in aged rats.2011

    • Author(s)
      Taguchi A, Zhu P, Cao F, Kikuchi-Taura A, Kasahara Y, Stern DM, Soma T, Matsuyama T, Hata R.
    • Journal Title

      J Cereb Blood Flow Metab. 31

      Pages: 855-867

    • Peer Reviewed
  • [Journal Article] Fine structural study of the regeneration of muscle fibers in the rat soleus muscle during aging.2011

    • Author(s)
      Desaki J, Nishida N.
    • Journal Title

      J Electron Microsc. 60

      Pages: 191-200

    • Peer Reviewed
  • [Journal Article] Conditional deletion of Stat3 promotes neurogenesis and inhibits astrogliogenesis in neural stem cells.2010

    • Author(s)
      Cao F, Hata R, Zhu P, Nakashiro K, Sakanaka M
    • Journal Title

      Biochem Biophys Res Commun. 394

      Pages: 843-847

    • Peer Reviewed
  • [Journal Article] Delayed neuronal cell death in brainstem after transient brainstem ischemia in gerbils.2010

    • Author(s)
      Cao F, Hata R, Zhu P, Takeda S, Yoshida T, Hakuba N, Sakanaka M, Gyo K.
    • Journal Title

      BMC Neurosci. 14;11

      Pages: 115-126

    • Peer Reviewed
  • [Journal Article] Risk of progression from mild memory impairment to clinically diagnosable Alzheimer disease in a Japanese community (from the Nakayama Study).2010

    • Author(s)
      Sonobe N, Hata R, Ishikawa T, Sonobe T, Matsumoto T, Toyota Y, Mori T, Fukunaga R, Komori K, Ueno S, Tanimukai S, Ikeda M
    • Journal Title

      Int Psychogeriatr. 16[Epub ahead of print]

      Pages: 1-8

    • Peer Reviewed
  • [Journal Article] Cancer stem-like cells of glioblastoma characteristically express MMP-13 and display highly invasive activity.2010

    • Author(s)
      Inoue A, Takahashi H, Harada H, Kohno S, Ohue S, Kobayashi K, Yano H, Tanaka J, Ohnishi T.
    • Journal Title

      Int J Oncol. 37

      Pages: 1121-1131

    • Peer Reviewed
  • [Journal Article] Retrosigmoid suprafloccular transhorizontal fissure approach for resection of brainstem cavernous malformation.2010

    • Author(s)
      Ohue S, Fukushima T, Friedman AH, Kumon Y, Ohnishi T.
    • Journal Title

      Neurosurgery. 66

      Pages: 306-312

    • Peer Reviewed
  • [Journal Article] Evaluation of intraoperative brain shift using an ultrasound-linked navigation system for brain tumor surgery.2010

    • Author(s)
      Ohue S, Kumon Y, Nagato S, Kohno S, Harada H, Nakagawa K, Kikuchi K, Miki H, Ohnishi T.
    • Journal Title

      Neurol Med Chir (Tokyo). 50

      Pages: 291-300

    • Peer Reviewed
  • [Journal Article] Surgical management of brainstem cavernomas : selection of approaches and microsurgical techniques.2010

    • Author(s)
      Ohue S, Fukushima T, Kumon Y, Ohnishi T, Friedman AH.
    • Journal Title

      Neurosurg Rev. 33

      Pages: 315-322

    • Peer Reviewed
  • [Journal Article] Iba1(+)/NG2(+) macrophage-like cells expressing a variety of neuroprotective factors ameliorate ischemic damage of the brain.2010

    • Author(s)
      Smirkin A, Matsumoto H, Takahashi H, Inoue A, Tagawa M, Ohue S, Watanabe H, Yano H, Kumon Y, Ohnishi T, Tanaka J.
    • Journal Title

      J Cereb Blood Flow Metab. 30

      Pages: 603-615

    • Peer Reviewed
  • [Journal Article] Fine structural study of the innervation of muscle spindles in the internal oblique muscle of the abdominal wall in the adult mouse.2010

    • Author(s)
      Desaki J, Ezaki T, Nishida N.
    • Journal Title

      J Electron Microsc. 59

      Pages: 243-250

    • Peer Reviewed
  • [Journal Article] A further observation of muscle spindles in the extensor digitorum longus muscle of the aged rat.2010

    • Author(s)
      Desaki J, Nishida N.
    • Journal Title

      J Electron Microsc. 59

      Pages: 79-86

    • Peer Reviewed
  • [Journal Article] Up-regulation of syntaxinl in ischemic cortex after permanent focal ischemia in rats.2009

    • Author(s)
      Cao F, Hata R, Zhu P, Niinobe M, Sakanaka M
    • Journal Title

      Brain Res. 1272

      Pages: 52-61

    • Peer Reviewed
  • [Journal Article] Ischemic tolerance in the cochlea.2009

    • Author(s)
      Takeda S, Hata R, Cao F, Yoshida T, Hakuba N, Hato N, Gyo K
    • Journal Title

      Neurosci Lett. 462

      Pages: 263-266

    • Peer Reviewed
  • [Journal Article] A small lamellar corpuscle within a small nerve bundle outside the tendon of the rat soleus muscle.2009

    • Author(s)
      Desaki J, Nishida N.
    • Journal Title

      J Electron Microsc. 58

      Pages: 67-72

    • Peer Reviewed
  • [Journal Article] Downregulation of SPARC expression inhibits cell migration and invasion in malignant gliomas.2009

    • Author(s)
      Seno T, Harada H, Kohno S, Teraoka M, Inoue A, Ohnishi T.
    • Journal Title

      Int J Oncol. 34

      Pages: 707-715

    • Peer Reviewed
  • [Journal Article] Postischemic mild hypothermia alleviates hearing loss because of transient ischemia.2008

    • Author(s)
      Takeda S, Hakuba N, Yoshida T, Fujita K, Hato N, Hata R, Hyodo J, Gyo K
    • Journal Title

      Neuroreport. 19

      Pages: 1325-1328

    • Peer Reviewed
  • [Journal Article] Ramified microglial cells promote astrogliogenesis and maintenance of neural stem cells through activation of Stat3 function.2008

    • Author(s)
      Zhu P, Hata R, Cao F, Gu F, Hanakawa Y, Hashimoto K, Sakanaka M
    • Journal Title

      FASEB J. 22

      Pages: 3866-3877

    • Peer Reviewed
  • [Journal Article] Accumulation of macrophage-like cells expressing NG2 proteoglycan and Iba1 in ischemic core of rat brain after transient middle cerebral artery occlusion.2008

    • Author(s)
      Matsumoto H, Kumon Y, Watanabe H, Ohnishi T, Shudou M, Chuai M, Imai Y, Takahashi H, Tanaka J.
    • Journal Title

      J Cereb Blood Flow Metab. 28

      Pages: 149-163

    • Peer Reviewed
  • [Journal Article] Postoperative temporary neurological deficits in adults with moyamoya disease.2008

    • Author(s)
      Ohue S, Kumon Y, Kohno K, Watanabe H, Iwata S, Ohnishi T.
    • Journal Title

      Surg Neurol. 69

      Pages: 281-286

    • Peer Reviewed
  • [Journal Article] Scanning electron microscopic observation of the sensory region in the frog muscle spindle.2008

    • Author(s)
      Desaki J.
    • Journal Title

      J Electron Microsc. 57

      Pages: 143-147

    • Peer Reviewed
  • [Journal Article] Regeneration of muscle fibers in the extensor digitorum longus muscle of the aged rat.2008

    • Author(s)
      Desaki J.
    • Journal Title

      J Electron Microsc. 57

      Pages: 59-66

    • Peer Reviewed
  • [Journal Article] Novel muscle spindles containing muscle fibers devoid of sensory innervation in the extensor digitorum longus muscle of aged rats.2008

    • Author(s)
      Desaki J, Nishida N.
    • Journal Title

      J Electron Microsc. 57

      Pages: 77-82

    • Peer Reviewed
  • [Remarks] ホームページ等

URL: 

Published: 2012-01-26   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi