2010 Fiscal Year Final Research Report
Examination of simple and easy detection procedure in the cerebrospinal fluid leakage diagnosis
| Project/Area Number |
20591691
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Cerebral neurosurgery
|
|---|
| Research Institution | Nagoya City University |
|---|
Principal Investigator |
NISHIO Minoru Nagoya City University, 大学院・医学研究科, 助教 (40315891)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MASE Mitsuhito 名古屋市立大学, 大学院・医学研究科, 准教授 (60238920)
YAMADA Kazuo 名古屋市立大学, 大学院・医学研究科, 教授 (90150341)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
SAKURAI Keita 名古屋市立大学, 大学院・医学研究科, 助教 (70453066)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | 脳脊髄液減少症 / 低髄液圧症候群 / L-PDGS |
|---|
| Research Abstract |
We measured the lipocain-type prostaglandin D synthetase (L-PDGS) in the cerebrospinal fluid (CSF) and serum samples from 6 patients with CSF leakage and 6 patients without CSF leakage. The L-PDGS levels in the blood serum were compared for a group of patients with and without CSF leakage, for a group of patients with low CSF pressure and normal CSF pressure, and for a group of patients with and without CSF leakage after a lumbar puncture. In the comparison of any groups, significant concentrations of L-PGDS in the blood serum were not detected. Therefore, we conclude that even if a minute amount of CSF leakage occurs, it is difficult to evaluate because it does not affect the L-PDGS concentration levels in the patients' blood.
|
