2010 Fiscal Year Final Research Report
Cerebral hyperperfusion and cognitive impairment after carotid endarterectomy are associated with free radicals produced during surgery
| Project/Area Number |
20591694
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Iwate Medical University |
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Principal Investigator |
OGASAWARA Kuniaki Iwate Medical University, 医学部, 教授 (00305989)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 脳血管障害学 |
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| Research Abstract |
The aim of the present study was to clarify relationship between development of postoperative cerebral hyperperfusion or cognitive impairment and value of free radicals produced during surgery using electrical spin trapping for blood obtained from catheter set at the jugular bulb in patients undergoing carotid endarterectomy. As a result, value of free radical production during surgery correlated with intensity of cerebral ischemia during carotid occlusion, and excessive free radical production caused postoperative cerebral hyperperfusion and cognitive impairment. Value of free radical production during surgery was significantly lower in patients with free radical scavenger, edaravone, than in those without.
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