2010 Fiscal Year Final Research Report
Application of liposome decorated with sugar chains to prevent vascular stenosis after angioplasty
| Project/Area Number |
20591700
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Cerebral neurosurgery
|
|---|
| Research Institution | National Institute of Advanced Industrial Science and Technology |
|---|
Principal Investigator |
TSURUSHIMA Hideo National Institute of Advanced Industrial Science and Technology, 大学院・人間総合科学研究科, 准教授 (50315470)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | 脳血管内外科学 |
|---|
| Research Abstract |
Restenosis remains a serious complication that can occur after angioplasty. This study investigated the efficiency of an active targeting chemotherapy using liposomes,including doxorubicin, which surface was decorated with sialyl Lewis X (SLX), (Dox-Lipo-SLX), to prevent stenosis after angioplasty. Its delivery was controlled via the affinity between SLX and E-selectin proteins, which are expressed on injured arteries. In vitro experiments confirmed that doxorubicin accumulated owing to Dox-Lipo-SLX by adhering to E-selectin-positive cells. Rats with balloon-injured arteries were intravenously injected with Dox-Lipo-SLX. A significant doxorubicin accumulation was observed on the injured vessel walls in rats treated with Dox-Lipo-SLX. The efficiency of stenosis prevention was evaluated. The residual lumen area of the group treated with Dox-Lipo-SLX was significantly larger than all of the other groups. These results demonstrate that an active targeting drug delivery system with Dox-Lipo-SLX effectively prevents stenosis after angioplasty.
|
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Remarks] ホームページ等
-
[Remarks] 取材報道
-
[Remarks] メディカルトリビューン紙2009年5月7日 Vol.42 No.19 p16「Stroke2009 臨床導入を目指した脳卒中に対する先端治療研究を報告:血管形成術後再狭窄予防active targeting DDSに期待」において研究内容が報道された
-
[Remarks] 医学書院/週刊医学界新聞第2828号 2009年4月27日「あらためて今「脳卒中」を知るStroke 2009:最先端治療法の臨床応用」において研究内容が報道された
-
[Remarks] メディカルトリビューン紙 2010年8月19日 VOL.43 NO.33 p36「第26回日本DDS学会ラジカル含有環境応答性ナノ粒子によるDDSを創製」にて研究内容が報道された
-
-
-
