2010 Fiscal Year Final Research Report
Analysis of a particle with membrane fusion protein for boron neutron capture therapy
| Project/Area Number |
20591705
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
NAKAI Kei University of Tsukuba, 大学院・人間総合科学研究科, 講師 (50436284)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMURA Akira 筑波大学, 大学院・人間総合科学研究科, 教授 (90241819)
YAMAMOTO Tetsuya 筑波大学, 大学院・人間総合科学研究科, 講師 (30375505)
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| Project Period (FY) |
2008 – 2010
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| Keywords | ホウ素 / リポソーム / 中性子 / 悪性脳腫瘍 / 膜融合 |
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| Research Abstract |
The Boron Neutron Capture Therapy (BNCT) has been used clinically for the treatment of malignant tumors. Two drugs, p-boronophenylalanine (BPA) and the sulfhydral borane (BSH) have been used. We developed the new boron delivery system with Liposome encapsulated Boron compounds, borono-porphyrin, and vesicle with membrane fusion proteins. Cell boron concentration was measured. The results showed this delivery system could be applicable for BNCT.
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