2010 Fiscal Year Final Research Report
The Elucidation of Mechanisms Underlying Resistance to Molecular Targeted Therapy in Malignant Gliomas and Development of Novel Therapeutic Strategy.
| Project/Area Number |
20591706
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MUKASA Akitake The University of Tokyo, 医学部附属病院, 特任講師 (90463869)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Minoru 東京大学, 医学部附属病院, 助教 (50332581)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 悪性神経膠腫 / 上皮性増殖因子受容体 / 分子標的治療 / 薬剤耐性 / 腫瘍幹細胞 |
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| Research Abstract |
The aim of this project was to identify key molecules among genes named as Substitute for EGFR* Expression (SE*Es) which are presumed to contribute to the resistance against therapy for malignant glioma, and to clarify their functions. First we categorized clinical specimens of malignant gliomas into basic subclasses based on genetic analyses and established several cell lines of brain tumor stem-like cells. Then to detect whether expressions of SE*E genes are elevated in human malignant gliomas and brain tumor stem-like cells, we investigated genomic amplification and gene expression in these tumor samples and consequently could pick up potentially important candidate genes which are subjected to further analyses.
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[Journal Article] Tumor Heterogeneity is an Active Process Maintained by a Mutant EGFR-induced Cytokine Circuit in Glioblastoma.2010
Author(s)
Inda MM, Bonavia R, Mukasa A, Narita Y, Sah DW, Vandenberg S, Brennan C, Johns TG, Bachoo R, Hadwiger P, Tan P, Depinho RA, Cavenee W, Furnari F
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Journal Title
Genes & Development. 24巻
Pages: 1731-1745
Peer Reviewed
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[Remarks] ホームページ等
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