2010 Fiscal Year Final Research Report
Genetic analysis of glioblastoma cancer stem cell with special reference to chronological and spatial change
| Project/Area Number |
20591708
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kanazawa University |
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Principal Investigator |
HAYASHI Yutaka Kanazawa University, 医学系, 准教授 (90262568)
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| Research Collaborator |
NAKADA Mitsutoshi 金沢大学, 医学系, 助教 (20334774)
KITA Daisuke 金沢大学, 医学系, 助教 (10377385)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 脳腫瘍 / 神経膠芽腫 / 腫瘍幹細胞 |
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| Research Abstract |
To evaluate the specific factors in tumorigenesis of the glioblastoma, especially in chronological and spatial character, several genes expressions and mutations were analyzed. Among the integrins that could be related with invasion, the alpha 3 subunit had a significantly higher expression level in tumor stem cells. The alpha 3 subunit of integrin could play an important role in the tumor invasion. Furthermore, during a course of tumor progression, FAS and TP53 mutation were detected. These genetic alterations could be related with tumor progression with a malignant transformation.
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[Journal Article] The correlation between promoter methylation status and the expression level of O6-methylguanine-DNA methyltransferasein recurrent glioma.2011
Author(s)
Suzuki, T., Nakada, M., Yoshida, Y., Nambu, E., Furuyama, N., Kita, D., Hayashi, Y., Hayashi, Y., Hamada, JI.
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Journal Title
Jpn J Clin Oncol 41
Pages: 190-196
Peer Reviewed
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[Journal Article] The expression level of sphingosine-1-phosphate receptor type 1 is related to MIB-1 labeling index and predicts survival of glioblastoma patients.2010
Author(s)
Yoshida, Y., Nakada, M., Harada, T., Tanaka, S., Furuta, T., Hayashi, Y., Kita, D., Uchiyama, N., Hayashi, Y., Hamada, JI.
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Journal Title
J Neurooncol 98
Pages: 41-47
Peer Reviewed
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[Journal Article] Implication of 5-aminolevulinic acid fluorescence of the ventricular wall for postoperative communicating hydrocephalus associated with cerebrospinal fluid dissemination in patients with glioblastoma multiforme : a report of 7 cases.2010
Author(s)
Hayashi, Y., Nakada, M., Tanaka, S., Uchiyama, N., Hayashi, Y., Kita, D., Hamada, JI.
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Journal Title
J Neurosurg 112
Pages: 1015-1019
Peer Reviewed
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[Journal Article] BCL10 single nucleotide polymorphism and its association with CSF dissemination of primary intracranial germ cell tumors2009
Author(s)
Hayashi, Y., Watanabe, T., Nakada, M., Kita, D., Hayashi, Y., Uchiyama, N., Hamada, JI.
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Journal Title
Pediatr Neurosurg 45
Pages: 291-295
Peer Reviewed
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[Journal Article] Potential therapeutic effect of glycogen synthase kinase 3beta inhibition against human glioblastoma.2009
Author(s)
Miyashita, K., Kawakami, K., Nakada, M., Mai, W., Shakoori, A., Fujisawa, H., Hayashi, Y., Hamada, JI., Minamoto, T.
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Journal Title
Clin Cancer Res 15
Pages: 887-897
Peer Reviewed
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[Journal Article] A reevaluation of the primary diagnosis of hemangiopericytoma and the clinical importance of differential diagnosis from solitary fibrous tumor of the central nervous system.2009
Author(s)
Hayashi, Y., Uchiyama, N., Hayashi, Y., Nakada, M., Iwato, M., Kita, D., Higashi, R., Hirota, Y., Kai, Y., Kuratsu, J., Hamada, JI.
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Journal Title
Clin Neurol Neurosurg 111
Pages: 34-38
Peer Reviewed
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[Journal Article] Secondary anaplastic astrocytoma developing in a young adult with autoimmune lymphoproliferative syndrome (ALPS).
Author(s)
Kita, D., Hayashi, Y., Watanabe, T., Korshunov, A., vonDeimling, A., Nakada, M., Kasahara, Y., Zen, Y., Hamada, JI., Hayashi, Y.
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Journal Title
Neuropathol Appl Neurobiol in press
Peer Reviewed
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