Towards molecular classification and individualized treatment of gliomas

2010 Fiscal Year Final Research Report

• Project/Area Number: 20591721
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Keio University
• Principal Investigator: SASAKI Hikaru Keio University, 医学部, 講師 (70245512)
• Co-Investigator(Kenkyū-buntansha): HIROSE Yuichi 藤田保健衛生大学, 医学部, 教授 (60218849)
• Co-Investigator(Renkei-kenkyūsha): YOSHIDA Kazunari 慶應義塾大学, 医学部, 教授 (70166940)
• Project Period (FY): 2008 – 2010
• Keywords: 脳腫瘍学

Research Abstract

We have prospectively conducted, on a daily basis, molecular studies on all resected gliomas including CGH and methylation-specific PCR of the MGMT gene. As a result, we found that adult supratentorial grade 2-3 gliomas are divided into clinically relevant subgroups by genetic profile (Hirose, 2011), and that single-copy gain of chromosome 1q is frequent in pediatric gliomas, and is associated with poor clinical outcome (Miwa, 2011). Moreover, we have treated 21 1p/19q-codeleted gliomas by neoadjuvant approach, and, of them, second-look removal after chemotherapeutic response was performed in 8 cases. There has been no recurrence in those tumors, and our results suggest efficacy of neoadjuvant approach for chemosensitive gliomas.

Research Products

• [Journal Article] Aggressive large cell medulloblastoma extending to the extracranial region in brain-dead statea. (2011)
  • Author(s): Miwa T, Oi S, Nonaka Y, Tamogami R, Sasaki H, Akiyama M, Yuza Y, Yokoi K, Yokokawa Y, Ida H
  • Journal Title: Childs Nerv Syst 原著 (in press)
  • Peer Reviewed
• [Journal Article] A glioblastoma arising from the attached region where a meningioma had been totally removed. (2011)
  • Author(s): Ohba S, Shimizu K, Shibao S, Miwa T, Nakagawa T, Sasaki H, Murakami H
  • Journal Title: Neuropathology 原著 (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Whole genome analysis from microdissected tissue revealed adult supratentorial grade II-III gliomas are divided into clinically relevant subgroups by genetic profile. (2011)
  • Author(s): Hirose Y, Sasaki H, Miwa T, Ohba S, Ikeda E, Abe M, Ikeda S, Kobayashi M, Kawase T, Hasegawa M, Yoshida K
  • Journal Title: Neurosurgery 原著 (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Rapid spontaneous regression of multicentric infantile myofibromatosis in the posterior fossa and lumbar vertebra. (2011)
  • Author(s): Miwa T, Oi S, Nonaka Y, Tamogami R, Sasaki H, Akiyama M, Yuza Y, Yokoi K, Yokokawa Y, Ida H
  • Journal Title: Childs Nerv Syst 原著 27(3) Pages: 491-6
  • Peer Reviewed
• [Journal Article] Single copy gain of chromosome 1q is a negative prognostic marker in pediatric non-ependymal, non-pilocytic gliomas. (2011)
  • Author(s): Miwa T, Hirose Y, Sasaki H, Ezaki T, Yoshida K, Kawase T
  • Journal Title: Neurosurgery 原著 68(1) Pages: 206-12
  • Peer Reviewed
• [Journal Article] 退形成性神経膠腫の多施設共同試験 -世界における動向-(総説)新時代の脳腫瘍学 -診断、治療の最前線- (2010)
  • Author(s): 佐々木光
  • Journal Title: 日本臨床(日本臨床社, 大阪) 68巻 増刊号10 Pages: 616-627
• [Journal Article] Clear cell meningiomas : three case reports with genetic characterization and review of the literature (2010)
  • Author(s): Ohba S, Sasaki H, Kimura T, Ikeda E, Kawase T
  • Journal Title: Neurosurgery 原著 67 Pages: E870-871
  • Peer Reviewed
• [Journal Article] 専門医のための最新の知識-神経膠腫の遺伝子診断に基づくテーラーメード治療。(総説) (2010)
  • Author(s): 佐々木光、吉田一成、河瀬斌
  • Journal Title: 脳神経外科速報 20 Pages: 66-71
• [Journal Article] Genetic characterization of adult infratentorial gliomas. (2009)
  • Author(s): Miwa T, Hirose Y, Sasaki H, Ikeda E, Yoshida K, Kawase T
  • Journal Title: Journal of Neuro-Oncology 原著 91 Pages: 251-5
  • Peer Reviewed
• [Journal Article] 神経膠腫における遺伝子診断と個別化治療 (2008)
  • Author(s): 佐々木光、吉田一成、河瀬斌
  • Journal Title: 脳神経外科 総説 36 Pages: 355-69
• [Presentation] Gliomaにおける-1p/19q、+7各腫瘍群の放射線学的特徴に関する検討とその生物学的意義の考察 (2011)
  • Author(s): 西山悠也、長久伸也、安達一英、吉田耕一郎、川瀬 司、長谷川光広、佐々木光、安倍雅人、片田和広、廣瀬雄一
  • Organizer: 第29回日本脳腫瘍病理学会
  • Place of Presentation: 東京(口演)
  • Year and Date: 2011-05-21
• [Presentation] Low-grade gliomaの遺伝子診断とneoadjuvant approach (2010)
  • Author(s): 佐々木光、廣瀬雄一、戸田正博、大平貴之、吉田一成
  • Organizer: 第15回日本脳腫瘍の外科学会
  • Place of Presentation: 大阪(シンポジウム)
  • Year and Date: 2010-10-02
• [Presentation] Molecular-guided neoadjuvant approach for gliomas (2010)
  • Author(s): 佐々木光
  • Organizer: 第3回三重脳腫瘍セミナー
  • Place of Presentation: 津(招待口演)
  • Year and Date: 2010-09-10
• [Presentation] Neoadjuvant approach for gliomas (2010)
  • Author(s): Sasaki H, Hirose Y, Katayama M, Yoshida K, Ohira T, Kawase T
  • Organizer: 18th International conference on brain tumor research and therapy
  • Place of Presentation: Travemunde, Germany (口演)
  • Year and Date: 2010-05-20
• [Presentation] 遺伝子解析に基づくグリオーマの個別化治療 (2009)
  • Author(s): 佐々木光、廣瀬雄一、片山真、矢崎貴仁、戸田正博、吉田一成、河瀬斌
  • Organizer: 第27回日本脳腫瘍学会
  • Place of Presentation: 大阪(シンポジウム)
  • Year and Date: 2009-11-09
• [Presentation] Glioma genetics -history and clinical application- (2009)
  • Author(s): 佐々木光
  • Organizer: Fukui Temodal Forum 2009
  • Place of Presentation: 福井(招待口演)
  • Year and Date: 2009-10-01
• [Presentation] Genetic profiling of pediatric non-ependymal gliomas associated with temozolomide resistance. (2009)
  • Author(s): Ezaki T, Miwa T, Sasaki H, Hirose Y, Yoshida K, Kawase T
  • Organizer: 3rd Quadrennial Meeting of World Federation of Neuro-Oncology (WFNO)
  • Place of Presentation: Yokohama(口演)
  • Year and Date: 2009-05-14
• [Presentation] 遺伝子解析に基づく神経膠腫の個別化治療 (2008)
  • Author(s): 佐々木光、廣瀬雄一
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋(ワークショップ)
  • Year and Date: 2008-10-30
• [Presentation] 遺伝子診断に基づく神経膠腫の個別化治療 (2008)
  • Author(s): 佐々木光、矢崎貴仁、戸田正博、廣瀬雄一、吉田一成、河瀬斌
  • Organizer: 第26回日本脳腫瘍病理学会
  • Place of Presentation: 東京(シンポジウム)
  • Year and Date: 2008-05-23
• [Book] 脳腫瘍。(著書)(山口徹、北原光夫、福井次矢編)(今日の治療指針2012) (2012)
  • Author(s): 佐々木光
  • Publisher: 医学書院,東京(in press)
• [Book] 星細胞腫の治療選択.(著書)(秋元治朗、田中聡編)(東京脳腫瘍治療懇話会)(脳腫瘍実践ケーススタディ第2巻) (2010)
  • Author(s): 佐々木光
  • Total Pages: 55-58
  • Publisher: 株式会社エサップ, 東京
• [Book] 膠芽腫の治療:PD or pseudoPD(著書)(東京脳腫瘍治療懇話会編 秋元治朗、田中聡編)(脳腫瘍実践ケーススタディ第2巻) (2010)
  • Author(s): 佐々木光
  • Total Pages: 59-62
  • Publisher: 株式会社エサップ, 東京
• [Remarks] ホームページ等
  • URL: http://web.sc.itc.keio.ac.jp/ns/index.html