2010 Fiscal Year Final Research Report
Usefullness of novel boronated porphyrins for both BNCT and PDT
| Project/Area Number |
20591728
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Osaka Medical College |
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Principal Investigator |
KAWABATA Shinji Osaka Medical College, 医学部, 助教 (20340549)
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| Co-Investigator(Kenkyū-buntansha) |
NONOGUCHI Naosuke 大阪医科大学, 医学部, 非常勤講師 (70388263)
YAMADA Yoshitaka 大阪医科大学, 医学部, 非常勤講師 (00368101)
IKEDA Naokado 大阪医科大学, 医学部, 助教 (50434775)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 脳腫瘍 / 粒子線治療 / ポルフィリン / 中性子捕捉療法 / 神経膠腫 / 光線力学療法 / Convection enhanced delivery |
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| Research Abstract |
In the boronated porphyrin, we give it as a PDD use at initial surgery in preoperation and perform PDT as intraoperative irradiation and would be able to measure the boron contents of the tumor in the individual patient. An advantage to be able to use this actual value in a judgment of indication, dose assessment was, thereby, thought about when we performed BNCT following surgery. Because the boronated porphyrin is full of visibility and shows high accumulation for the tumor, this compound can expect effect of treatment in the both PDT and BNCT.
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[Journal Article] Boron neutron capture therapy for newly diagnosed glioblastoma.2009
Author(s)
Kawabata S, Miyatake S, Kuroiwa T,Yokoyama K, Doi A, Iida K, Miyata S,Nonoguchi N, Michiue H, Takahashi M,Inomata T, Imahori Y, Kirihata M, Sakurai Y,Maruhashi A, Kumada H, Ono K
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Journal Title
J Radiat Res(Tokyo). 50
Pages: 51-60
Peer Reviewed
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