2010 Fiscal Year Final Research Report
Therapeutic effect of the polymeric micellar antineoplastic drugs infused convection-enhanced delivery against intracranial rat glioma models
| Project/Area Number |
20591730
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Miyagi Cancer Center Research Institute |
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Principal Investigator |
YAMASHITA Yoji Miyagi Cancer Center Research Institute, 研究所, 特任研究員 (30420045)
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| Co-Investigator(Kenkyū-buntansha) |
YOKOYAMA Masayuki 東京慈恵会医科大学, 医学部, 准教授 (20220577)
SONODA Yukihiko 東北大学, 病院, 講師 (90302140)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMA Hiroshi 宮城県立がんセンター(研究所), 薬物療法学部, 部長 (10196462)
TANUMA Nobuhiro 宮城県立がんセンター(研究所), 薬物療法学部, 研究員 (40333645)
NOMURA Miyuki 宮城県立がんセンター(研究所), 薬物療法学部, 技師 (40390893)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 脳腫瘍学 / 化学療法 |
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| Research Abstract |
Convection-enhanced delivery (CED) is a local infusion technique, which delivers chemotherapeutic agents directly to the central nervous system, circumventing the blood brain barrier and reducing systemic side effects. Although it is regrettable that we could not prepare polymeric micellar alkylating agents for CED in this project, we identified the candidate molecules for the treatment of malignant glioma, CDC25A and DUSP26, in the process of screening the aberrant expression of protein phosphatases.
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[Journal Article] CDC25A mRNA levels significantly correlate with Ki-67 expression in human glioma samples.2010
Author(s)
Yamashita Y, Kasugai I, Sato M, Tanuma N, Sato I, Nomura M, Yamashita K, Sonoda Y, Kumabe T, Tominaga T, Katakura R, Shima H
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Journal Title
J Neurooncol 100
Pages: 43-49
Peer Reviewed
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[Journal Article] Convection-enhanced delivery of a synthetic retinoid Am80, loaded into polymeric micelles, prolongs the survival of rats bearing intracranial glioblastoma xenografts.2010
Author(s)
Yokosawa M, Sonoda Y, Sugiyama S, Saito R, Yamashita Y, Nishihara M, Satoh T, Kumabe T, Yokoyama M, Tominaga T
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Journal Title
Tohoku J Exp Med 221
Pages: 257-264
Peer Reviewed
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[Journal Article] Protein phosphatase Dusp26 associates with KIF3 motor and promotes N-cadherin-mediated cell-cell adhesion.2009
Author(s)
Tanuma N, Nomura M, Ikeda M, Kasugai I, Tsubaki Y, Takagaki K, Kawamura T, Yamashita Y, Sato I, Sato M, Katakura R, Kikuchi K, Shima H
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Journal Title
Oncogene 28
Pages: 752-761
Peer Reviewed
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