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2010 Fiscal Year Final Research Report

Clinical application of artificial intervertebral disc and development of novel hybrid type regenerative disc

Research Project

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Project/Area Number 20591734
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionHokkaido University

Principal Investigator

KOTANI Yoshihisa  Hokkaido University, 病院, 講師 (40312368)

Co-Investigator(Kenkyū-buntansha) ABUMI Kuniyosi  北海道大学, 大学院・医学研究科, 教授 (00159419)
MINAMI Akio  北海道大学, 大学院・医学研究科, 教授 (20133738)
Project Period (FY) 2008 – 2010
Keywords脊椎脊髄病学 / 生体材料 / 椎間板 / 再生医学
Research Abstract

For clinical application of artificial disc, we received the starting approval from PMDA and continued the negotiation with US company. For the regenerative disc research, we selected mesenchymal stem cell or cultured nucleus cell for regenerative cells. The bioabsorbable microfiber was fabricated into the three-dimensional configuration for three-dimensional scaffold.

  • Research Products

    (18 results)

All 2011 2010 2009 2008

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (3 results) Book (3 results)

  • [Journal Article] A bimimetic artificial intervertebral disc system composed of a cubic three-dimensional fabric.2010

    • Author(s)
      Shikinami Y, Kawabe Y, Yasukawa K, Tsuta K, Kotani Y, Abumi K
    • Journal Title

      The Spine Journal 10

      Pages: 142-52

    • Peer Reviewed
  • [Journal Article] A late neurological complication followig posterior correction surgery of severe cervical kyphosis.2010

    • Author(s)
      Hojo Y, Ito M, Abumi K, Kotani Y, Sudo H, Takahata M, Minami A
    • Journal Title

      Eur Spine J Epub ahead of print

    • Peer Reviewed
  • [Journal Article] Neurological recovery after surgical treatment of giant cervical pseudomeningoceles extending to lumbar spine associated with previous brachial plexus injury.2010

    • Author(s)
      Kotani Y, Abumi K, Ito M, Terae S, Hisada Y, Minami A
    • Journal Title

      Eur Spine J

      Pages: S206-10

    • Peer Reviewed
  • [Journal Article] Simultaneous double-rod rotation technique in posterior instrumentation surgery for correction of adlescent idiopathic scoliosis.2010

    • Author(s)
      Ito M, Abumi K, Kotani Y, Takahata M, Sudo H, Hojo Y, Minami A
    • Journal Title

      J Neurosurg Spine 12

      Pages: 293-300

    • Peer Reviewed
  • [Journal Article] One-stage posterior instrumentation surgery for the treatment of osteoporotic vertebral collapse with neuurological defects.2010

    • Author(s)
      Sudo H, Ito M, Abumi K, Kotani Y, Takahata M, Hojo Y, Minami A
    • Journal Title

      Eur Spine J 19

      Pages: 907-15

    • Peer Reviewed
  • [Journal Article] 脊椎脊髄外科におけるMotion Preservation Technology:脊椎可動性温存技術の現状と本邦発の人工椎間板臨床応用への取り組み2010

    • Author(s)
      小谷善久、鐙邦芳、伊東学、三浪明男
    • Journal Title

      Journal of Spine Research 1

      Pages: 8-16

    • Peer Reviewed
  • [Journal Article] Spinal cord compression by ligamentum flavum hematoma in the thoracic spine.2009

    • Author(s)
      Sudo H, Abumi K, Ito M., Kotani Y, Takahata M, Minami A
    • Journal Title

      Spine 34

      Pages: E942-4

    • Peer Reviewed
  • [Journal Article] Minimmaly invasive surgical treatment for tuberculous spondylodiscitis.2009

    • Author(s)
      Ito M, Sudo H, Abumi K, Kotani Y, Takahata M, Fujita M, Minami A
    • Journal Title

      Minim Invas Neurosurg 52

      Pages: 1-4

    • Peer Reviewed
  • [Journal Article] Minimum two-year outcome of cervical laminoplasty with deep extensor muscle preserving approach : Impact on cervical spine function and quality of life.2009

    • Author(s)
      Kotani Y, Abumi K, Ito M, Sudo H, Takahata M, Ohshima S, Hojo Y, Minami A
    • Journal Title

      Eur Spine J 18

      Pages: 663-71

    • Peer Reviewed
  • [Journal Article] Neurological recovery from pentaplegia after surgical treatment of sacral plasmacytoma presenting POEMS syndrome. Case report.2009

    • Author(s)
      Kotani Y, Ito M, Abumi K, Yasui K, Minami A
    • Journal Title

      J Neurosurg Spine 10

      Pages: 324-28

    • Peer Reviewed
  • [Journal Article] 脊椎脊髄外科におけるMotion Preservation Technology(総説)2009

    • Author(s)
      小谷善久、鐙邦芳、三浪明男
    • Journal Title

      日本腰痛学会雑誌 15(日本腰痛学会優秀論文賞受賞)

      Pages: 86-94

    • Peer Reviewed
  • [Journal Article] Clinical results and complications of circumferential spinal cord decompression through a single posterior approach for thoracic myelopathy caused by ossification of posterior longitudinal ligament.2008

    • Author(s)
      Takahata M, Ito M, Abumi K, Kotani Y, Sudo H, Minami A
    • Journal Title

      Spine. 33

      Pages: 1199-208

    • Peer Reviewed
  • [Presentation] Development and clinical application of biomimetic artificial interverte bral disc with the unique structure of three-dimensional fabric.2009

    • Author(s)
      小谷善久、鐙邦芳、三浪明男
    • Organizer
      第13回脊椎と神経を語る会
    • Place of Presentation
      横浜市
    • Year and Date
      2009-03-14
  • [Presentation] 脊椎脊髄外科におけるバイオメカニクスと最近の知見2009

    • Author(s)
      小谷善久
    • Organizer
      第4回大阪バイオメカニクス研究会
    • Place of Presentation
      大阪市
    • Year and Date
      2009-03-07
  • [Presentation] 脊椎脊髄外科におけるMotion Preservation Technology2008

    • Author(s)
      小谷善久
    • Organizer
      第16回日本腰痛学会
    • Place of Presentation
      東京(日本腰痛学会優秀論文賞受賞)
    • Year and Date
      2008-11-01
  • [Book] the Cranivertebral junction(Goel A, Cassiola F, ed.)(Occipitocervical stabilization.)2011

    • Author(s)
      Abumi K, Ito M, Kotani Y
    • Total Pages
      110-128
    • Publisher
      Thieme-Stuttgart
  • [Book] 2010 American Academy of Orthopaedic Surgeons(Cervical pedicle screw fixation. Chapter 21)2010

    • Author(s)
      Abumi K, Ito M, Kotani Y
    • Total Pages
      1-11
  • [Book] Cervical Spine Truma(Vaccaro A and Andersson P, ed.)(Subaxial injuries : Pillar (Pedicle and lateral mass) fractures.)2009

    • Author(s)
      Abumi K, Kotani Y, Ito M, Vaccaro A
    • Total Pages
      409-419
    • Publisher
      Rothman institute

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Published: 2012-01-26   Modified: 2016-04-21  

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