2010 Fiscal Year Final Research Report
Novel therapeutic strategy for osteosarcoma using sex hormones
| Project/Area Number |
20591749
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KAWANO Hirotaka The University of Tokyo, 医学部附属病院, 講師 (20345218)
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| Co-Investigator(Kenkyū-buntansha) |
KADONO Yuho 東京大学, 医学部附属病院, 助教 (70401065)
SHINODA Yusuke 東京大学, 医学部附属病院, 助教 (80456110)
KOBAYASHI Hiroshi 東京大学, 医学部附属病院, 助教 (20407951)
OKUMA Tomotake 東京大学, 医学部附属病院, 助教 (90534909)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 骨肉腫 / 性ホルモン / 治療 |
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| Research Abstract |
Therapeutic strategy for osteosarcoma has grown stagnant since 1980's. In this study, we showed the anti-tumor effect of Laroxifen (SERM: selective estrogen receptor modulator) on osteosarcoma in vitro. Moreover, in a murine sarcoma metastases model using osteosarcoma cell line LM8, female mice lived significantly longer than male mice and ovariectomized female mice. These observations indicated that female sex hormones might be candidates as new therapeutic strategy for osteosarcoma.
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