2010 Fiscal Year Final Research Report
Novel therapeutic modality for metastatic bone disease of breast cancer via hyaluronan inhibition
| Project/Area Number |
20591751
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Nagoya University |
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Principal Investigator |
NISHIDA Yoshihiro Nagoya University, 医学系研究科, 准教授 (50332698)
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| Co-Investigator(Kenkyū-buntansha) |
TSUKUSHI Satoshi 名古屋大学, 医学部附属病院, 病院助教 (90378109)
WASA Junji 名古屋大学, 医学部附属病院, 医員 (80547539)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 糖鎖 / 乳癌 / 骨転移 / ヒアルロン酸 / 保存的治療 |
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| Research Abstract |
4-MU (4-methylumbelliferone), an inhibitor for hyaluronan synthesis, and hyaluronan oligosaccharides, which has shown to suppress endogenous hyaluronan, effectively showed anti-tumor effect on breast and lung cancer. Moreover, these reagents significantly suppressed metastatic bone lesion of breast and lung cancer without serious complications. Together, 4-MU and hyaluronan oligosaccharides might be a promising novel therapeutic tools for metastatic bone disease.
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