Novel therapy for metastatic sarcoma to the lung using extracellular matrix protein : decorin.

2010 Fiscal Year Final Research Report

• Project/Area Number: 20591752
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Mie University
• Principal Investigator: MATSUMINE Akihiko Mie University, 大学院・医学系研究科, 准教授 (00335118)
• Co-Investigator(Kenkyū-buntansha): UCHIDA Atsumasa 三重大学, 学長 (40176681) ; KUSUZAKI Katsuyuki 京都府立研究開発センタ, 特認教授 (30177993) ; WAKABAYASHI Hiroki 三重大学, 医学部附属病院, 講師 (50362687) ; KUMAMOTO Tadashi 三重大学, 大学院・医学系研究科, 助教 (50362348) ; AKEDA Koji 三重大学, 医学部附属病院, 助教 (20422826)
• Project Period (FY): 2008 – 2010
• Keywords: デコリン / 細胞外基質タンパク / 悪性骨軟部腫瘍 / 肉腫 / 遠隔転移 / 肺転移

Research Abstract

We discovered that decorin suppress lung metastasis of osteosarcoma and bone metastasis of breast cancer. Furthermore, we showed that minimum active region for anti-tumor effect may be the TGF-b binding site which exists in the core protein of decorin. Decorin is a natural product and has no immunogenicity. Therefore, these results suggest that decorin represents the new therapeutic modality to prevent pulmonary metastasis in osteosarcoma.

Research Products

• [Journal Article] TNF inhibitor suppresses bone metastasis in a breast cancer cell line. (2011)
  • Author(s): Hamaguchi T, Wakabayashi H, Matsumine A, Sudo A, Uchida A.
  • Journal Title: Biochem Biophys Res Commun. in press
  • Peer Reviewed
• [Journal Article] Retrospective analysis of metastatic sarcoma patients. (2011)
  • Author(s): Nakamura T, Matsumine A, Matsubara T, Asanuma K, Niimi R, Uchida A, Sudo A.
  • Journal Title: Oncology Letters in press
  • Peer Reviewed
• [Journal Article] Sudo A Extraslkeletal subcutaneous osateosarcoma of the upper arm : A case report. (2011)
  • Author(s): Nakamura T, Matsumine A, Nishimura K, Yokoyama H, Murata T, Uchida A
  • Journal Title: Oncology Letters. 2 Pages: 75-77
  • Peer Reviewed
• [Journal Article] Recurrent ankle equinus deformity due to intramuscular hemangioma of the gastrocnemius. (2011)
  • Author(s): Nakamura T, Matsumine A, Nishiyama M, Miura Y, Matsubara T, Asanuma K, Uchida A, Sudo A.
  • Journal Title: Foot Ankle Int. in press
  • Peer Reviewed
• [Journal Article] A novel hyperthermia treatment for bone metastases using magnetic materials. (2011)
  • Author(s): Matsumine A, Takegami K, Asanuma K, Matsubara T, Nakamura T, Uchida A, Sudo A.
  • Journal Title: Int J Clin Oncol. in press
  • Peer Reviewed
• [Journal Article] Transfection of NF-κB decoy oligodeoxynucleotide suppresses pulmonary metastasis by murine osteosarcoma. (2011)
  • Author(s): Nishimura A, Akeda K, Matsubara T, Kusuzaki K, Matsumine A, Masuda K, Gemba T, Uchida A, Sudo A.
  • Journal Title: ancer Gene Ther. 18 Pages: 250-259
  • Peer Reviewed
• [Journal Article] Clinical outcomes of the KYOCERA Physio Hinge Total Knee System Type III after the resection of a bone and soft tissue tumor of the distal part of the femur. (2011)
  • Author(s): Matsumine A, Ueda T, Sugita T, Yazawa Y, Isu K, Kawai A, Abe S, Yakushiji T, Hiraga H, Sudo A, Uchida A.
  • Journal Title: J Surg Oncol in press
  • Peer Reviewed
• [Journal Article] Clinical outcomes of minimally invasive surgery using acridine orange for musculoskeletal sarcomas around theforearm, compared with conventional limb salvage surgery after wide resection. (2010)
  • Author(s): Matsubara T, Kusuzaki K, Matsumine A, Murata H, Nakamura T, Uchida A, Sudo A.
  • Journal Title: J Surg Oncol. 102 Pages: 271-275
  • Peer Reviewed
• [Journal Article] The cleavage of N-cadherin is essential for chondrocyte differentiation. (2010)
  • Author(s): Nakazora S, Matsumine A, Iino T, Hasegawa M, Kinoshita A, Uemura K, Niimi R, Uchida A, Sudo A.
  • Journal Title: Biochem Biophys Res Commun. 400 Pages: 493-499
  • Peer Reviewed
• [Journal Article] Photodynamic therapy with acridine orange in musculoskeletal sarcomas. (2010)
  • Author(s): Matsubara T, Kusuzaki K, Matsumine A, Murata H, Marunaka Y, Hosogi S, Uchida A, Sudo A.
  • Journal Title: J Bone Joint Surg Br. 92 Pages: 760-762
  • Peer Reviewed
• [Journal Article] Expression of ADAMTS4 in Ewing's sarcoma. (2010)
  • Author(s): Minobe K, Ono R, Matsumine A, Shibata-Minoshima F, Izawa K, Oki T, Kitaura J, Iino T, Takita J, Iwamoto S, Hori H, Komada Y, Uchida A, Hayashi Y, Kitamura T,Nosaka T.
  • Journal Title: Int J Oncol 37 Pages: 569-581
  • Peer Reviewed
• [Journal Article] Significance of LRP and PPAR-gamma Expression in Lipomatous Soft Tissue Tumors. (2010)
  • Author(s): Tajima T, Morii T, Kikuchi F, Matsumine A, Murata H, Nobuto H, Mochizuki K.
  • Journal Title: Open Orthop J. 4 Pages: 48-55
  • Peer Reviewed
• [Journal Article] The expression of hDlg as a biomarker of the outcome in malignant fibrous histiocytomas. (2010)
  • Author(s): Niimi R, Matsumine A, Iino T, Murata T, Shintani K, Nakazora S, Nakamura T,Uehara Y, Kusuzaki K, Akiyama T, Uchida A.
  • Journal Title: Oncol Rep. 23 Pages: 631-638
  • Peer Reviewed
• [Journal Article] Fibulin-3 negatively regulates chondrocyte differentiation. (2010)
  • Author(s): Wakabayashi T, Matsumine A, Nakazora S, Hasegawa M, Iino T, Ota H, Sonoda H,Sudo A, Uchida A.
  • Journal Title: Biochem Biophys Res Commun. 391 Pages: 1116-1121
  • Peer Reviewed
• [Journal Article] Epithelioid hemangioendothelioma after radiotherapy for congenital hemangioma : a case report. (2010)
  • Author(s): Niimi R, Matsumine A, Kusuzaki K, Shintani K, Nakamura T, Kotera H, Murata T,Uchida A.
  • Journal Title: Med Oncol. 27 Pages: 130-133
  • Peer Reviewed
• [Journal Article] Multiple cutaneous squamous cell carcinomas in a patient withinterferon gamma receptor 2 (IFN gamma R2) deficiency. (2010)
  • Author(s): Toyoda H, Ido M, Nakanishi K, Nakano T, Kamiya H, Matsumine A, Uchida A, Mizutani H, de Beaucoudrey L, Vogt G, Boisson-Dupuis S, Bustamante J, CasanovaJL, Komada Y.
  • Journal Title: J Med Genet. 47 Pages: 631-634
  • Peer Reviewed
• [Journal Article] Diffuse skeletal muscle metastasis from gastric cancer similar to inflammmatory disease : a report of two patients. (2010)
  • Author(s): Satonaka H, Hamaguchi T, Wakabayashi T, Urawa M, Inada H, Takegami K, Matsumine A, Uchida A.
  • Journal Title: Current Orthopaedic Practice 21 Pages: 310-314
  • Peer Reviewed
• [Journal Article] Three-dimensional alginate spheroid culture system of murine osteosarcoma. (2009)
  • Author(s): Akeda K, Nishimura A, Satonaka H, Shintani K, Kusuzaki K, Matsumine A, Kasai Y, Masuda K, Uchida A.
  • Journal Title: Oncol Rep. 22 Pages: 997-1003
  • Peer Reviewed
• [Journal Article] Decorin suppresses bone metastasis in a breast cancer cell line. (2009)
  • Author(s): Araki K, Wakabayashi H, Shintani K, Morikawa J, Matsumine A, Kusuzaki K, SudoA, Uchida A.
  • Journal Title: Oncology. 77 Pages: 92-99
  • Peer Reviewed
• [Journal Article] Lumbar metastasis of choriocarcinoma. (2009)
  • Author(s): Naito Y, Akeda K, Kasai Y, Matsumine A, Tabata T, Nagao K, Uchida A.
  • Journal Title: Spine 197634 Pages: 538-543
  • Peer Reviewed
• [Journal Article] Differentiation between neurofibromas and malignant peripheral nerve sheath tumors in neurofibromatosis 1 evaluated by MRI. (2009)
  • Author(s): Matsumine A, Kusuzaki K, Nakamura T, Nakazora S, Niimi R, Matsubara T, Uchida K, Murata T, Kudawara I, Ueda T, Naka N, Araki N, Maeda M, Uchida A.
  • Journal Title: J Cancer Res Clin Oncol. 135 Pages: 891-900
  • Peer Reviewed
• [Journal Article] A new therapeutic modality involving acridine orange excitation by photon energy used during reduction surgery for rhabdomyosarcomas. (2009)
  • Author(s): Matsubara T, Kusuzaki K, Matsumine A, Murata H, Satonaka H, Shintani K, Nakamura T, Hosoi H, Iehara T, Sugimoto T, Uchida A.
  • Journal Title: Oncol Rep. 21 Pages: 89-94
  • Peer Reviewed
• [Journal Article] Lung radiofrequency ablation in patients with pulmonary metastases from musculoskeletal sarcomas [corrected]. (2009)
  • Author(s): Nakamura T, Matsumine A, Yamakado K, Matsubara T, Takaki H, Nakatsuka A, Takeda K, Abo D, Shimizu T, Uchida A.
  • Journal Title: Cancer. 115 Pages: 3774-3781
  • Peer Reviewed
• [Journal Article] Management of small pulmonary nodules in patients with sarcoma. (2009)
  • Author(s): Nakamura T, Matsumine A, Niimi R, Matsubara T, Kusuzaki K, Maeda M, Tagami T, Uchida A.
  • Journal Title: Clin Exp Metastasis. 26 Pages: 713-718
  • Peer Reviewed
• [Journal Article] Malignant melanoma with a rhabdoid phenotype exhibiting numerous solid tumor masses : a case report. (2009)
  • Author(s): Nakamura T, Matsumine A, Kato H, Kusuzaki K, Nishimura K, Murata T, Shiraishi T, Oda Y, Tsuneyoshi M, Uchida A.
  • Journal Title: Oncol Rep. 21 Pages: 887-891
  • Peer Reviewed
• [Journal Article] Matrix metalloproteinase-1 is a crucial bone metastasis factor in a human breast cancer-derived highly invasive cell line. (2008)
  • Author(s): Okuyama N, Matsumine A, Kosugi R, Wakabayashi H, Uchida A.
  • Journal Title: Oncol Rep. 20 Pages: 1497-1504
  • Peer Reviewed
• [Journal Article] Asymptomatic disseminated carcinomatosis of bone marrow presenting as hyperphosphatasia : report of a case. (2008)
  • Author(s): Hori K, Sudo A, Wakabayashi H, Matsumine A, Kusuzaki K, Uchida A.
  • Journal Title: Acta Gastroenterol Belg. 71 Pages: 271-274
  • Peer Reviewed
• [Journal Article] Decorin suppresses lung metastases of murine osteosarcoma. (2008)
  • Author(s): Shintani K, Matsumine A, Kusuzaki K, Morikawa J, Matsubara T, Wakabayashi T, Araki K, Satonaka H, Wakabayashi H, Iino T, Uchida A.
  • Journal Title: Oncol Rep. 19 Pages: 1533-1539
  • Peer Reviewed
• [Journal Article] Usefulness of limb salvage surgery for bone and soft tissue sarcomas of the distal lower leg. (2008)
  • Author(s): Niimi R, Matsumine A, Kusuzaki K, Kuratsu S, Araki N, Aoki Y, Ueda T, Kudawara I, Myoui A, Ieguchi M, Hashimoto N, Yoshikawa H, Uchida A.
  • Journal Title: J Cancer Res Clin Oncol. 134 Pages: 1087-1095
  • Peer Reviewed
• [Journal Article] Prognostic implication of SYT-SSX fusion type in synovial sarcoma : a multi-institutional retrospective analysis in Japan. (2008)
  • Author(s): Takenaka S, Ueda T, Naka N, Araki N, Hashimoto N, Myoui A, Ozaki T, Nakayama T, Toguchida J, Tanaka K, Iwamoto Y, Matsumine A, Uchida A, Ieguchi M, Kaya M, Wada T, Baba I, Kudawara I, Aoki Y, Yoshikawa H.
  • Journal Title: Oncol Rep. 19 Pages: 467-476
  • Peer Reviewed
• [Journal Article] Spinal neurocutaneous melanosis without cutaneous nevi. (2008)
  • Author(s): Asanuma K, Kasai Y, Takegami K, Ito H, Yoshikawa T, Uchida A.
  • Journal Title: Spine (Phila Pa 1976). 33 Pages: 798-801
  • Peer Reviewed
• [Journal Article] Effect of osteogenic protein-1 on the matrix metabolism of bovine tendon cells. (2008)
  • Author(s): Yamada M, Akeda K, Asanuma K, Thonar EJ, An HS, Uchida A, Masuda K.
  • Journal Title: J Orthop Res. 26 Pages: 42-48
  • Peer Reviewed
• [Journal Article] Methylene blue in place of acridine orange as a photosensitizer in photodynamic therapy of osteosarcoma. (2008)
  • Author(s): Matsubara T, Kusuzaki K, Matsumine A, Satonaka H, Shintani K, Nakamura T, Uchida A.
  • Journal Title: In Vivo. 22 Pages: 297-303
  • Peer Reviewed
• [Journal Article] Histiocytic osteolysis secondary to hyperbilirubinaemia : a case report. (2008)
  • Author(s): Nakamura T, Kusuzaki K, Matsubara T, Satonaka H, Shintani K, Wakabayashi T, Matsumine A, Uchida A.
  • Journal Title: J Orthop Surg (Hong Kong). 16 Pages: 263-266
  • Peer Reviewed
• [Journal Article] A new limb salvage surgery in cases of high-grade soft tissue sarcoma using photodynamic surgery, followed by photo- and radiodynamic therapy with acridine orange. (2008)
  • Author(s): Nakamura T, Kusuzaki K, Matsubara T, Matsumine A, Murata H, Uchida A.
  • Journal Title: J Surg Oncol. 97 Pages: 523-528
  • Peer Reviewed
• [Journal Article] Foreign-body granulomas in the trunk and extremities may simulate malignant soft-tissue tumors : report of three cases. (2008)
  • Author(s): Nakamura T, Kusuzaki K, Matsubara T, Matsumine A, Uchida A.
  • Journal Title: Acta Radiol. 49 Pages: 80-83
  • Peer Reviewed
• [Presentation] Lung radiofrequency ablation in patients with lung metastases from soft tissue sarcomas. (2010)
  • Author(s): Nakamura T, Matsumine A, Yamakado K, Matsubara T, Asanuma K, Uchida A, Sudo A.
  • Organizer: CTOS 16th Annual
  • Place of Presentation: Paris
  • Year and Date: 20101011-20101113
• [Presentation] Inhibition of coagulation activity by warfarin down-regulates lung metastasis. (2010)
  • Author(s): Asanuma K, Matsumine A, Matsubara T, Nakamura T, Uchida A, Sudo A.
  • Organizer: CTOS 16th Annual Meeting
  • Place of Presentation: Paris
  • Year and Date: 20101011-20101013
• [Presentation] Novel hyperthermia for metastatic bone tumors with magnetic materials. (2010)
  • Author(s): Matsumine A, Nakamura T, Matsubara T, Asanuma K, Atsumi S, Uchida A, Sudo T.
  • Organizer: CTOS 16th Annual Meeting
  • Place of Presentation: Paris
  • Year and Date: 20101011-20101013
• [Presentation] Minimal invasive therapy for metastatic bone tumors. (2010)
  • Author(s): Matsumine A.
  • Organizer: SABI meeting
  • Place of Presentation: Shanghai
  • Year and Date: 20101011-20101013
• [Presentation] Lung radiofrequency ablation in patients with lung metastases from musculoskeletal sarcomas (2010)
  • Author(s): Nakamura T, Matsumine A, Yamakado K, Niimi R, Nakazora S, Matsubara T, Uchida A, Sudo A
  • Organizer: 8th. Asia Pacific Musculoskeletal Tumor Society Meeting
  • Place of Presentation: Cebu
  • Year and Date: 20100724-20100727
• [Presentation] Usefulness of prosthetic limb salvage surgery for the bone and soft tissue tumors around the knee (2010)
  • Author(s): Niimi R, Matsumine A, Hamaguchi T, Nakamura T, Matsubara T, Uchida A, Sudo A
  • Organizer: 8th. Asia Pacific Musculoskeletal Tumor Society Meeting
  • Place of Presentation: Cebu
  • Year and Date: 20100724-20100727
• [Presentation] Clinical Outcomes with the KYOCERA Physio Hinge Total Knee System Type III after the Resection of a bone and soft tissue tumor of the Distal Part of the Femur : from the Japanese Musculoskeletal Oncology Group (2010)
  • Author(s): Matsumine A, Kusuzaki K, Sugita T, Yazawa Y, Isu K, Kawai A, Abe S, Yakushiji T, Ueda T, Uchida A
  • Organizer: 8th. Asia Pacific Musculoskeletal Tumor Society Meeting
  • Place of Presentation: Cebu
  • Year and Date: 20100724-20100727
• [Presentation] Clinical outcome of Mie Osteosarcoma Study Protocol (MOS protocol) in the treatment of osteosarcoma patient (2010)
  • Author(s): Hori K, Matsumine A, Hamaguchi T, Niimi R, Nakamura T, Uchida A, Sudo A
  • Organizer: 8th. Asia Pacific Musculoskeletal Tumor Society Meeting
  • Place of Presentation: Cebu
  • Year and Date: 20100724-20100727
• [Presentation] Fibulin-3 suppress the chondrogenic differentiation by preventing the cleavage of N-cadherin (2009)
  • Author(s): Nakazora S, Matsumine A, Wakabayashi T, Niimi R, Nakamura T, Matsubara T, Nakoshi R, Iino T, Akeda K, Hasegawa M, Kusuzaki K, Sudo A, Uchida A.
  • Organizer: 55th Annual Meeting of the Orthopaedic Research Society
  • Place of Presentation: LasVegas
  • Year and Date: 20090722-20090725
• [Presentation] Expression of SAP97 as a biomarker of outcome in malignant fibrous histiocytomas (2009)
  • Author(s): Niimi R, Matsumine A, 1Iino T, Shintani K, Nakazora S, Nakamura T, Kusuzaki K, Uchida A.
  • Organizer: 55th Annual Meeting of the Orthopaedic Research Society
  • Place of Presentation: Las Vegas
  • Year and Date: 20090722-20090725
• [Presentation] Total femoral replacement after resection of malignant musculoskeletal tumors (2008)
  • Author(s): Nakazora S, Matsumine A, Nakamura T, Niimi R, Kusuzaki K, Uchida A.
  • Organizer: 7th. Asia Pacific Musculoskeletal Tumor Society Meeting
  • Place of Presentation: Beijing
  • Year and Date: 20080226-20080228
• [Presentation] Limb salvage surgery for bone and soft tissue of the distal lower leg (2008)
  • Author(s): Niimi R, Matsumine A, Kusuzaki K, Nakamura T, Nakazora S, Kuratsu S, Araki N, Aoki Y, Ueda T, Kudawara I, Myoui A, Ieguchi M, Hashimoto N, Yoshikawa H, Uchida A.
  • Organizer: 7th. Asia Pacific Musculoskeletal Tumor Society Meeting
  • Place of Presentation: Beijing
  • Year and Date: 20080226-20080228
• [Presentation] Novel hyperthermia for metastatic bone tumors with magnetic materials (2008)
  • Author(s): Matsumine A, Kusuzaki K, Nakamura T, Niimi R, Nakazora S, Matsubara T, Satonaka H, Uchida A.
  • Organizer: 7th. Asia Pacific Musculoskeletal Tumor Society Meeting
  • Place of Presentation: Beijing
  • Year and Date: 20080226-20080228
• [Book] 薬局増刊号、病気と薬パーフェクトBOOK2011, 骨肉腫 (2011)
  • Author(s): 松原孝夫、松峯昭彦、須藤啓広
  • Total Pages: 1784-1787
  • Publisher: 南山堂
• [Book] 腫瘍薬学-骨軟部腫瘍- (2010)
  • Author(s): 松峯昭彦
  • Total Pages: 392-400
  • Publisher: 南山堂
• [Book] 入門腫瘍内科学、骨軟部腫瘍 (2009)
  • Author(s): 松峯昭彦, 内田淳正
  • Total Pages: 214-217
  • Publisher: 篠原出版新社
• [Book] 骨・関節術後感染対策ハンドブック, 腫瘍手術後の感染症に対する治療 (2009)
  • Author(s): 松峯昭彦, 内田淳正
  • Total Pages: 134-142
  • Publisher: 南江堂
• [Remarks] ホームページ等
  • URL: http://www.medic.mie-u.ac.jp/seikeigeka/