2010 Fiscal Year Final Research Report
Studies in targets of SYT-SSX fusion protein in synovial sarcoma.
| Project/Area Number |
20591756
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Okayama University |
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Principal Investigator |
OUCHIDA Mamuru Okayama University, 大学院・医歯薬学総合研究科, 准教授 (80213635)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 滑膜肉腫 / 染色体転座 / 融合遺伝子 |
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| Research Abstract |
The aim of this study was identification of the target genes transcriptionally regulated by SYT-SSX fusion protein in synovial sarcomas. We found about 300 candidate targets by chromatin immunoprecipitation assay, DNA cloning and sequencing. We have screened the reagents which can block and inhibit the localization of SYT-SSX fusion protein in synovial sarcoma cells, to find new targeted therapy agents for synovial sarcoma.
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