2010 Fiscal Year Final Research Report
Enhancement of cartilage differentiation of mesenchymal stem cells with Wnt protein stimulation
| Project/Area Number |
20591758
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
ADACHI Nobuo Hiroshima University, 病院, 准教授 (30294383)
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| Co-Investigator(Kenkyū-buntansha) |
OCHI Mitsuo 広島大学, 病院, 教授 (70177244)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 変形性関節症 / 再生医学 / Wnt / 関節軟骨 |
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| Research Abstract |
Me senchymal stem cells (MSC) have been considered as good candidate as cell source in regenerative medicine. On the other hand, it is reported that Wnt protein can affect cartilage differentiation of those cells. This study clearly demonstrated that supplementation of Wnt5a protein enhanced cartilage differentiation of MSC in three-dimensional culture system.
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