Establishment of anti-angiogenic therapy for soft tissue sarcomsas

2010 Fiscal Year Final Research Report

• Project/Area Number: 20591762
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Sapporo Medical University
• Principal Investigator: KAYA Mitsunori Sapporo Medical University, 医学部, 講師 (10398315)
• Co-Investigator(Kenkyū-buntansha): WADA Takuro 札幌医科大学, 道民医療推進学講座, 特任教授 (00244369) ; YAMASHITA Toshihiko 札幌医科大学, 医学部, 教授 (70244366)
• Project Period (FY): 2008 – 2010
• Keywords: 軟部肉腫 / 遠隔転移 / 局所浸潤 / 血管新生

Research Abstract

To establish the anti-angiogenic therapy for soft tissue sarcomas, the risk factors of the local recurrence of myxofibrosarcoma were retrospectively analyzed. Inadequate surgical margins and bone and/or joint attachment were associated with an increased recurrence rate. Further evaluation of the role of angiogenesis to invasiveness of myxofibrosarcoma will be necessary for the establishment of anti-angiogenic therapy for soft tissue sarcoma.

Research Products

• [Journal Article] The leve of vascular endothelial growth factor as predictor of a poor prognosis in osteosarcoma. (2009)
  • Author(s): DKava M, Wada T, Nagoya S, Sasaki M, Matsumura T, Yamashita T.
  • Journal Title: J Bone Joint Surg 91B Pages: 1142-1147
  • Peer Reviewed
• [Presentation] High serum levels of VEGF predict poor prognosis for patients with osteosarcoma : A prospective study 2010 (2011)
  • Author(s): Kava M, Wada T Nagoya S, Sasaki M, Emori M, Yamashita T.
  • Organizer: 78th American Academy of Orthopedic Surgeons
  • Place of Presentation: San Diego, U S A
  • Year and Date: 20110200
• [Presentation] Risk Factors for local recurrence of myxofibrosarcoma (2010)
  • Author(s): Kava M, Wada T Nagoya S, Sasaki M, Emori M, Yamashita T.
  • Organizer: 2010 Connective tissue Oncology Society Meeting.
  • Place of Presentation: Paris
  • Year and Date: 2010-11-11
• [Presentation] High serum levels of VEGF predict poor prognosis for patients with osteosarcoma : A prospective study (2010)
  • Author(s): Kava M, Wada T Nagoya S, Sasaki M Emori M, Yamashita T.
  • Organizer: 2010 Connective tissue Oncology Society Meeting
  • Place of Presentation: Paris
  • Year and Date: 2010-11-11
• [Presentation] Risk Factors for local recurrence of zmyxofibrosarcoma. (2010)
  • Author(s): Kava M, Wada T Nagoya S, Sasaki M, Emori M, Yamashita T.
  • Organizer: The 20^<th> Japanese-Korean Comibined Orthopaedic Symposium
  • Place of Presentation: Ibusuki
  • Year and Date: 2010-06-03
• [Presentation] Radiological and histological evaluation of the infiltrative growth pattern of myxofibrosarcoma (2009)
  • Author(s): Kava M, Wada T. Nagoya S, Sasaki M, Yamashita T.
  • Organizer: International Symposium of : Lim Salvage and the Musculoskeletal Tumor Society
  • Place of Presentation: Boston, U S A
  • Year and Date: 20090923-20090926
• [Presentation] Radiological and histological evaluation of the infiltrative growth pattern of myxofibrosarcoma (2009)
  • Author(s): Kava M, Wada T Nagoya S, Sasaki M, Matsuura T, Kosukegawa I, Yamashita T.
  • Organizer: 76th American Academy of Orthopedic Surgeons
  • Place of Presentation: Las Vegas, USA
  • Year and Date: 20090225-20090228