2011 Fiscal Year Final Research Report
Studies on the operative technique and the cytokines required to reproduce a normal bone-ligament junction in the knee ligament reconstruction
| Project/Area Number |
20591769
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | Kurume University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NAGATA Kensei 久留米大学, 医学部, 教授 (50140687)
|
|---|
| Research Collaborator |
MURAKAMI Hidetaka 久留米大学, 医学部, 講師
KANAZAWA Tomonoshin 久留米大学, 医学部, 助教
KATOU Damichihiro 久留米大学, 医学部, 助教
TABUCHI Kousuke 久留米大学, 大学院, 大学院生
NOYAMA Megumi 久留米大学, 大学院, 大学院生
|
|---|
| Project Period (FY) |
2008 – 2011
|
| Keywords | 膝 / 靭帯 / 再建術 / 骨.靭帯移行部 / ACL / PCL |
|---|
| Research Abstract |
On immunohistological search of the rat, although ligament insertion site is completely bipolarized into the ligament cell which produces type I collagen at a viviparous period and the epiphysial cartilage cell which produces type II collagen, both cells re-arrange regularly to a fibrous direction after birth. In the boundary part, it seemed that a part of ligament cell transmuted into the cartilage cell and a part of cartilage cell transmuted into the ligament cell, with revelation of Sox9. (2) A direction of the anchor fiber came to agree with the mechanical axis of the grafted tendon when we changed the operation method from the conventional bone-tunnel method to our original method without bone-tunnel, although the tendon-bone junction was a fibrous union. (3) The cartilaginous bone-tendon junction through the layer of type II collagen which resembled to a normal bone-tendon junction was found by some individuals, when the bone marrow-derived mesenchymal stem cell which has multipotency and/or Sox 9 which is considered to be one of the key-factors by the experiment-1 were introduced into the our reconstruction model which established by the experiment-2.
|
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 骨-移植腱間錨着の免疫組織学的検討2009
Author(s)
金澤知之進, 副島崇, 村上秀孝, 井上貴司, 田渕幸祐, 野口幸志, 加藤田倫宏, 野山めぐみ, 永田見生
Organizer
日本整形外科学会基礎学術集会(パネルディスカッション)
Place of Presentation
横浜
Year and Date
2009-11-06
-
-
-
-
-
-
-
-
-
-
-
-
-
-
