2010 Fiscal Year Final Research Report
Development of target therapy for SSX of sarcoma metastasis
| Project/Area Number |
20591771
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses |
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Principal Investigator |
YOSHIOKA Kiyoko Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses, 研究所, 研究員 (40342993)
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| Co-Investigator(Kenkyū-buntansha) |
ITOH Kazuyuki 地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), 研究所, 部長 (20301806)
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHIKAWA Hideki 大阪大学, 大学院・医学系研究科器官制御外科学, 教授 (60191558)
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| Project Period (FY) |
2008 – 2010
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| Keywords | SSX / 骨軟部腫瘍 / 浸潤 / 転移 |
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| Research Abstract |
The SSX genes were initially identified as fusion partners to the SS18 gene in synovial sarcoma. Besides adult human testis, SSX genes were highly expressed in sarcoma, and positively correlated with clinical stage, especially the metastatic case present very high SSX expression. Our results suggested that SSXs would be novel proteins regulate cancer metastasis and potential molecular target(s) under clinical setting.
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[Journal Article] Suppression of Colon Cancer Metastasis by Aes through Inhibition of Notch Signaling2011
Author(s)
Sonoshita, M., Aoki, M., Fuwa, H., Aoki K., Hosogi, H., Sakai, Y., Hashida, H., Takabayashi, A., Sasaki, M., Robine, S., Itoh K., Yoshioka K., Kakizaki, F., Kitamura, T., Oshima, M., Taketo. M.M.
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Journal Title
Cancer Cell 19
Pages: 125-137
Peer Reviewed
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[Journal Article] Mesenchymal mode of migration participates in pulmonary metastasis of mouse osteosarcoma LM8.2010
Author(s)
Yui, Y., Itoh K., Yoshioka K., Naka N., Watanabe, M., Hiraumi, Y., Matsubara, H., Watanabe, K., Sano, K., Nakahata, T., Adachi, S.
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Journal Title
Clin Exp Metastasis 27
Pages: 619-630
Peer Reviewed
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[Journal Article] Synovial Sarcoma Is a Stem Cell Malignancy.2010
Author(s)
Naka N., Takenaka S., Araki N., Miwa, T., Hashimoto, N., Yoshioka K., Joyama, S., Hamada, K., Tsukamoto, Y., Tomita, Y., Ueda, T., Yoshikawa, H., Itoh K.
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Journal Title
Stem Cells 28
Pages: 1119-1131
Peer Reviewed
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[Journal Article] Downregulation of SS18-SSX1 expression in synovial sarcoma by small interfering RNA enhances the focal adhesion pathway and inhibits anchorage-independent growth in vitro and tumor growth in vivo.2010
Author(s)
Takenaka S., Naka N., Araki N., Hashimoto, N., Ueda, T., Yoshioka K.,, Yoshikawa, H., Itoh K.
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Journal Title
Int.J.Oncology 36(4)
Pages: 823-831
Peer Reviewed
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