2010 Fiscal Year Final Research Report
Elucidation of the regulatory mechanism of early chondrocyte differentiation and application of cartilage repair
| Project/Area Number |
20591776
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
JINNO Tetsuya Tokyo Medical and Dental University, 医学部附属病院, 講師 (90343152)
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| Co-Investigator(Renkei-kenkyūsha) |
SHINOMIYA Ken-ichi 東京医科歯科大学, 医歯学総合研究科, 教授 (20111594)
ASOU Yoshinori 東京医科歯科大学, 医学部附属病院, 助教 (50345279)
TAKEDA Shu 慶應義塾大学, 医学部, 准教授 (30376727)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 関節病学 |
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| Research Abstract |
We uncovered that, by means of Runx1 conditional mutant mice, Runx1 and Runx2 cooperatively regulates early chondrocyte differentiation thorough the induction of Sonx5 and Sox6.
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[Journal Article] Runx1 and Runx2 cooperate during sternal morphogenesis.2010
Author(s)
Kimura A, Inose H, Yano F, Fujita K, Ikeda T, Sato S, Iwasaki M, Jinno T, Ae K, Fukumoto S, Takeuchi Y, Itoh H, Imamura T, Kawaguchi H, Chung UI, Martin JF, Iseki S, Shinomiya K, Takeda S
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Journal Title
Development. 137(7)
Pages: 1159-1167
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[Journal Article] The distinct role of the Runx proteins in chondrocyte differentiation and intervertebral disc degeneration : Findings in murine models and in human disease.2008
Author(s)
Sato S, Kimura A, Ozdemir J, Asou Y, Miyazaki M, Jinno T, Ae K, Liu X, Osaki M, Takeuchi Y, Fukumoto S, Kawaguchi H, Haro H, Shinomiya K, Karsenty G, Takeda S
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Journal Title
Arthritis Rheum. 58(9)
Pages: 2764-2765
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[Presentation] 特発性大腿骨頭壊死に対する高気圧酸素治療2008
Author(s)
柳下和慶, 山見信夫, 外川誠一郎, 金剛寺純子, 岡崎史紘, 田之畑諒, 神野哲也, 古賀大介, 宗田大, 四宮謙一, 眞野喜洋
Organizer
日本高気圧環境・潜水医学会雑誌(0388-5577)43巻3号Page152
Year and Date
20080900
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[Remarks] ホームページ等
