2010 Fiscal Year Final Research Report
Prevention and treatment of joint diseases by normalization of the subchondral bone
| Project/Area Number |
20591779
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | Tottori University |
|---|
Principal Investigator |
TESHIMA Ryota Tottori University, 医学部, 教授 (50144671)
|
|---|
| Research Collaborator |
林 育太 鳥取大学, 大学院生
林原 雅子 鳥取大学, 大学院生
谷田 敦 鳥取大学, 大学院生
土海 敏幸 鳥取大学, 大学院生
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | 軟骨下骨組織 / 関節軟骨 / 関節リウマチ / 関節破壊 / 骨脆弱性 / コラーゲン誘発関節炎 |
|---|
| Research Abstract |
Prevention and treatment of joint destruction due to arthritis were studied.
A prospective 1-year study showed that incidences of fall and fracture were 50% and 2.5% in women with rheumatoid arthritis (RA), respectively. Effect of raloxifene and etanercept on joint destruction in rats with collagen-induced arthritis was investigated. Raloxifene could suppress arthritis and bone loss and etanercept could promote bone formation. Development of vertical subluxation(VS) of the axis in patients with RA was investigated using CT. VS could be induced by destruction of the lateral mass of the atlas and axis.
|
