2010 Fiscal Year Final Research Report
Molecular mechanism of osteoarthritis-analysis of Gadd45beta transgenic mice-
| Project/Area Number |
20591787
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kagoshima University |
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Principal Investigator |
IJIRI Kosei Kagoshima University, 医歯学総合研究科, 准教授 (00315417)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 関節病学 |
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| Research Abstract |
Pathology of the osteoarthritis (OA) is uncovered. Gadd45β(growth arrest and DNA damaged inducible 45 beta) is a small protein (18kD) which is involved in cell cycle, apoptosis, stress, and hypertrophy. Since Gadd45β is characteristically expressed in clusters of early stage of OA, we hypothesized that Gadd45β is one of the key molecules in the process of OA. This study was designed to establish the conditional transgenic mice. The promoter of COMP was used in Tet-off system. DT mice was produced and the expression of Gadd45β was confirmed. C/EBPβ, the downstream of Gadd45β, DTmice was also produced and the gene expression was confirmed.
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[Journal Article] Activation of synoviolin promoter in rheumatoid synovial cells by a novel transcription complex of interleukin enhancer binding factor 3 and GA binding protein alpha.2009
Author(s)
Izumi T, Fujii R, Izumi T, Nakazawa M, Yagishita N, Tsuchimochi K, Yamano Y, Sato T, Fujita H, Aratani S, Araya N, Azakami K, Hasegawa D, Kasaoka S, Tsuruta R, Yokouti M, Ijiri K, Beppu M, Maruyama I, Nishioka K, Maekawa T, Komiya S, Nakajima T.
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Journal Title
Arthritis Rheum. 60(1)
Pages: 63-72
Peer Reviewed
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