A study on genes that associated with response to biologic agents.

2010 Fiscal Year Final Research Report

• Project/Area Number: 20591791
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: MOMOHARA Shigeki Tokyo Women's Medical University, 医学部, 教授 (00190984)
• Co-Investigator(Renkei-kenkyūsha): KARI Katsunori 東京女子医科大学, 医学部, 講師 (80343557)
• Project Period (FY): 2008 – 2010
• Keywords: リウマチ病学

Research Abstract

We tried to detect the genes that associated with response to biologic agents using disease-associated polymorphisms as candidate, and found that a SNP, rs10919563, on PTPRC gene is significantly associated with response to biologic agents (P<0.05). Since the SNP is also known as anti-TNF-α therapy response polymorphism in Caucasian, it seems to be a reliable result.

Research Products

• [Journal Article] Interleukin-18 promoter polymorphisms in Japanese patients with rheumatoid arthritis: protective effect of the T allele and T/T genotype at rs360722. (2011)
  • Author(s): Sugiura T, Kawaguchi Y, Ikari K, Ichida H, Kawamoto M, Momohara S, Hara M, Yamanaka H
  • Journal Title: Mod Rheumatol.
  • Peer Reviewed
• [Journal Article] Studies of the efficacy and safety of methotrexate at dosages over 8 mg/week using the IORRA cohort database. (2011)
  • Author(s): Seto Y, Tanaka E, Inoue E, Nakajima A, Taniguchi A, Momohara S, Yamanaka H
  • Journal Title: Mod Rheumatol.
  • Peer Reviewed
• [Journal Article] Recent trends in orthopedic surgery performed in Japan for rheumatoid arthritis. (2011)
  • Author(s): Momohara S, Tanaka S, Nakamura H, Mibe J, Iwamoto T, Ikari K, Nishino J, Kadono Y, Yasui T, Takahashi K, Takenouchi K, Hashizume K, Nakahara R, Kubota A, Nakamura T, Nishida K, Suguro T
  • Journal Title: Mod Rheumatol.
  • Peer Reviewed
• [Journal Article] Reparative radiological changes of a large joint after adalimumab for rheumatoid arthritis. (2011)
  • Author(s): Momohara S, Tanaka E, Iwamoto T, Ikari K, Yamanaka H
  • Journal Title: Clin Rheumatol. 30(4) Pages: 591-2
  • Peer Reviewed
• [Journal Article] 0Prosthetic joint infection after total hip or knee arthroplasty in rheumatoid arthritis patients treated with nonbiologic and biologic disease-modifying antirheumatic drugs. (2011)
  • Author(s): Momohara S, Kawakami K, Iwamoto T, Yano K, Sakuma Y, Hiroshima R, Imamura H, Masuda I, Tokita A, Ikari K
  • Journal Title: Mod Rheumatol.
  • Peer Reviewed
• [Journal Article] Efficacy of total joint arthroplasty in patients with established rheumatoid arthritis: improved longitudinal effects on disease activity but not on health-related quality of life. (2011)
  • Author(s): Momohara S, Inoue E, Ikari K, Yano K, Tokita A, Suzuki T, Sakuma Y, Hiroshima R, Kawakami K, Masuda I, Iwamoto T, Taniguchi A, Yamanaka H
  • Journal Title: Mod Rheumatol.
  • Peer Reviewed
• [Journal Article] Effect of total knee arthroplasty on disease activity in patients with established rheumatoid arthritis : 3-year follow-up results of combined medical therapy and surgical intervention. (2010)
  • Author(s): Yano K, Ikari K, Inoue E, Tokita A, Sakuma Y, Hiroshima R, Iwamoto T, Kawakami K, Taniguchi A, Yamanaka H, Momohara S
  • Journal Title: Mod Rheumatol. 20(5) Pages: 452-7
  • Peer Reviewed
• [Journal Article] Efficacy and tolerability of tocilizumab in rheumatoid arthritis patients seen in daily clinical practice in Japan : results from a retrospective study (REACTION study). (2010)
  • Author(s): Yamanaka H, Tanaka Y, Inoue E, Hoshi D, Momohara S, Hanami K, Yunoue N, Saito K, Amano K, Kameda H, Takeuchi T
  • Journal Title: Mod Rheumatol. 21(2) Pages: 122-33
  • Peer Reviewed
• [Journal Article] A novel ER J-protein DNAJB12 accelerates ER-associated degradation of membrane proteins including CFTR. (2010)
  • Author(s): Yamamoto YH, Kimura T, Momohara S, Takeuchi M, Tani T, Kimata Y, Kadokura H, Kohno K
  • Journal Title: Cell Struct Funct. 35(2) Pages: 107-16
  • Peer Reviewed
• [Journal Article] Incidence of falls and fear of falling in Japanese patients with rheumatoid arthritis. (2010)
  • Author(s): Yamagiwa K, Iijima S, Furuya T, Ikai T, Inoue E, Taniguchi A, Momohara S, Yamanaka H
  • Journal Title: Mod Rheumatol. 21(1) Pages: 51-6
  • Peer Reviewed
• [Journal Article] Incidence of malignancy in Japanese patients with rheumatoid arthritis. (2010)
  • Author(s): Yamada T, Nakajima A, Inoue E, Tanaka E, Taniguchi A, Momohara S, Yamanaka H
  • Journal Title: Rheumatol Int.
  • Peer Reviewed
• [Journal Article] Effects of long-term corticosteroid usage on functional disability in patients with early rheumatoid arthritis, regardless of controlled disease activity. (2010)
  • Author(s): Tanaka E, Mannalithara A, Inoue E, Iikuni N, Taniguchi A, Momohara S, Singh G, Yamanaka H
  • Journal Title: Rheumatol Int.
  • Peer Reviewed
• [Journal Article] The association of a nonsynonymous single-nucleotide polymorphism in TNFAIP3 with systemic lupus erythematosus and rheumatoid arthritis in the Japanese population. (2010)
  • Author(s): Shimane K, Kochi Y, Horita T, Ikari K, Amano H, Hirakata M, Okamoto A, Yamada R, Myouzen K, Suzuki A, Kubo M, Atsumi T, Koike T, Takasaki Y, Momohara S, Yamanaka H, Nakamura Y, Yamamoto K
  • Journal Title: Arthritis Rheum. 62(2) Pages: 574-9
  • Peer Reviewed
• [Journal Article] Comparison of the second and third generation anti-cyclic citrullinated peptide antibody assays in the diagnosis of Japanese patients with rheumatoid arthritis. (2010)
  • Author(s): Shidara K, Inoue E, Tanaka E, Hoshi D, Seto Y, Nakajima A, Momohara S, Taniguchi A, Yamanaka H
  • Journal Title: Rheumatol Int. 31(5) Pages: 617-22
  • Peer Reviewed
• [Journal Article] Anti-cyclic citrullinated peptide antibody predicts functional disability in patients with rheumatoid arthritis in a large prospective observational cohort in Japan. (2010)
  • Author(s): Shidara K, Inoue E, Hoshi D, Sato E, Nakajima A, Momohara S, Taniguchi A, Yamanaka H.
  • Journal Title: Rheumatol Int.
  • Peer Reviewed
• [Journal Article] Incidence of and risk factors for interstitial pneumonia in patients with rheumatoid arthritis in a large Japanese observational cohort, IORRA. (2010)
  • Author(s): Shidara K, Hoshi D, Inoue E, Yamada T, Nakajima A, Taniguchi A, Hara M, Momohara S, Kamatani N,Yamanaka H
  • Journal Title: Mod Rheumatol. 20(3) Pages: 280-6
  • Peer Reviewed
• [Journal Article] Reparative radiological changes of the hip joint in rheumatoid arthritis : do these findings indicate the true repair of the joint? (2010)
  • Author(s): Sakuma Y, Ikari K, Iwamoto T, Tokita A, Momohara S.
  • Journal Title: Joint Bone Spine. 77(3) Pages: 278-9
  • Peer Reviewed
• [Journal Article] Single nucleotide polymorphisms of CD244 gene predispose to renal and neuropsychiatric manifestations with systemic lupus erythematosus. (2010)
  • Author(s): Ota Y, Kawaguchi Y, Takagi K, Tochimoto A, Kawamoto M, Katsumata Y, Gono T, Masuda I, Ikari K, Momohara S, Yamanaka H.
  • Journal Title: Mod Rheumatol. 20(5) Pages: 427-31
  • Peer Reviewed
• [Journal Article] Association of EMCN with susceptibility to rheumatoid arthritis in a Japanese population. (2010)
  • Author(s): Nishimoto K, Ikari K, Kaneko H, Tsukahara S, Kochi Y, Yamamoto K, Nakamura Y, Toyama Y, Taniguchi A, Yamanaka H, Momohara S
  • Journal Title: J Rheumatol. 38(2) Pages: 221-8
  • Peer Reviewed
• [Journal Article] Rheumatoid arthritis: a risk factor for deep venous thrombosis after total knee arthroplasty? Comparative study with osteoarthritis. (2010)
  • Author(s): Niki Y, Matsumoto H, Hakozaki A, Mochizuki T, Momohara S
  • Journal Title: J Orthop Sci. 15(1) Pages: 57-63
  • Peer Reviewed
• [Journal Article] Mortality and cause of death in Japanese patients with rheumatoid arthritis based on a large observational cohort, IORRA. (2010)
  • Author(s): Nakajima A, Inoue E, Tanaka E, Singh G, Sato E, Hoshi D, Shidara K, Hara M, Momohara S, Taniguchi A, Kamatani N, Yamanaka H
  • Journal Title: Scand J Rheumatol. 39(5) Pages: 360-7
  • Peer Reviewed
• [Journal Article] Neglected spontaneous rupture of the Achilles tendon in elderly patients with rheumatoid arthritis. (2010)
  • Author(s): Mikashima Y, Kawamura K, Miyawaki M, Murakoshi K, Usami N, Momohara S
  • Journal Title: J Clin Rheumatol. 16(5) Pages: 221-4
  • Peer Reviewed
• [Journal Article] A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility. (2010)
  • Author(s): Kochi Y, Okada Y, Suzuki A, Ikari K, Terao C, Takahashi A, Yamazaki K, Hosono N, Myouzen K, Tsunoda T, Kamatani N, Furuichi T, Ikegawa S, Ohmura K, Mimori T, Matsuda F, Iwamoto T, Momohara S, Yamanaka H, Yamada R, Kubo M, Nakamura Y, Yamamoto K
  • Journal Title: Nat Genet. 42(6) Pages: 515-9
  • Peer Reviewed
• [Journal Article] Efficacy and safety of tacrolimus in 101 consecutive patients with rheumatoid arthritis. (2010)
  • Author(s): Kitahama M, Okamoto H, Koseki Y, Inoue E, Kaneko H, Taniguchi A, Momohara S, Yamanaka H
  • Journal Title: Mod Rheumatol. 20(5) Pages: 478-85
  • Peer Reviewed
• [Journal Article] Clinical images : Solitary extranodal malignant lymphoma of the forearm in rheumatoid arthritis. (2010)
  • Author(s): Iwamoto T, Seto Y, Ikari K, Yamanaka H, Momohara S
  • Journal Title: Arthritis Rheum. 63(1) Pages: 304
  • Peer Reviewed
• [Journal Article] Analysis of C-reactive protein levels and febrile tendency after joint surgery in rheumatoid arthritis patients treated with a perioperative 4-week interruption of tocilizumab. (2010)
  • Author(s): Hiroshima R, Kawakami K, Iwamoto T, Tokita A, Yano K, Sakuma Y, Ikari K, Momohara S
  • Journal Title: Mod Rheumatol. 21(1) Pages: 109-11
  • Peer Reviewed
• [Journal Article] Associations between methotrexate treatment and methylenetetrahydrofolate reductase gene polymorphisms with incident fractures in Japanese female rheumatoid arthritis patients (2009)
  • Author(s): Urano W, Furuya T, Inoue E, Taniguchi A, Urano T, Kotake S, Sekita C, Inoue S, Hara M, Momohara S, Kamatani N, Yamanaka H
  • Journal Title: J Bone Miner Metab. 27(5) Pages: 574-83
  • Peer Reviewed
• [Journal Article] Medical care costs of patients with rheumatoid arthritis during the prebiologics period in Japan : a large prospective observational cohort study (2009)
  • Author(s): Tanaka E, Inoue E, Mannalithara A, Bennett M, Kamitsuji S, Taniguchi A, Momohara S, Hara M, Singh G, Yamanaka H
  • Journal Title: Mod Rheumatol. 20(1) Pages: 46-53
  • Peer Reviewed
• [Journal Article] The intra-articular efficacy of hyaluronate injections in the treatment of rheumatoid arthritis. (2009)
  • Author(s): Saito S, Momohara S, Taniguchi A, Yamanaka H
  • Journal Title: Mod Rheumatol. 19(6) Pages: 643-51
  • Peer Reviewed
• [Journal Article] Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese. (2009)
  • Author(s): Nishimoto K, Kochi Y, Ikari K, Yamamoto K, Suzuki A, Shimane K, Nakamura Y, Yano K, Iikuni N, Tsukahara S, Kamatani N, Okamoto H, Kaneko H, Kawaguchi Y, Hara M, Toyama Y, Horiuchi T, Tao K, Yasutomo K, Hamada D, Yasui N, Inoue H, Itakura M, Yamanaka H, Momohara S
  • Journal Title: Ann Rheum Dis. 69(2) Pages: 368-73
• [Journal Article] Is minimally invasive surgery in total knee arthroplasty really minimally invasive surgery? (2009)
  • Author(s): Niki Y, Mochizuki T, Momohara S, Saito S, Toyama Y, Matsumoto H.
  • Journal Title: J Arthroplasty. 24(4) Pages: 499-504
  • Peer Reviewed
• [Journal Article] Decrease in orthopaedic operations, including total joint replacements, in patients with rheumatoid arthritis between 2001 and 2007 : data from Japanese outpatients in a single institute-based large observational cohort (IORRA). (2009)
  • Author(s): Momohara S, Inoue E, Ikari K, Kawamura K, Tsukahara S, Iwamoto T, Hara M, Taniguchi A, Yamanaka H
  • Journal Title: Ann Rheum Dis. 69(1) Pages: 312-3
  • Peer Reviewed
• [Journal Article] Declining use of synovectomy surgery for patients with rheumatoid arthritis in Japan. (2009)
  • Author(s): Momohara S, Ikari K, Mochizuki T, Kawamura K, Tsukahara S, Toki H, Hara M, Kamatani N, Yamanaka H, Tomatsu T.
  • Journal Title: Ann Rheum Dis. 68(2) Pages: 291-2
  • Peer Reviewed
• [Journal Article] In vivo deep-flexion kinematics in patients with posterior-cruciate retaining and anterior-cruciate substituting total knee arthroplasty. (2009)
  • Author(s): Mikashima Y, Tomatsu T, Horikoshi M, Nakatani T, Saito S, Momohara S, Banks SA
  • Journal Title: Clin Biomech (Bristol, Avon). 25(1) Pages: 83-7
  • Peer Reviewed
• [Journal Article] T-cell leukemia translocation-associated gene (TCTA) protein is required for human osteoclastogenesis. (2009)
  • Author(s): Kotake S, Nanke Y, Kawamoto M, Yago T, Udagawa N, Ichikawa N, Kobashigawa T, Saito S, Momohara S, Kamatani N, Yamanaka H
  • Journal Title: Bone. 45(4) Pages: 627-39
  • Peer Reviewed
• [Journal Article] A case of isolated gouty tophus in a patient without a previous history of gouty arthritis. (2009)
  • Author(s): Kobayashi S, Taniguchi A, Okamoto H, Momohara S, Tomatsu T.
  • Journal Title: J Clin Rheumatol. 15(7) Pages: 373
  • Peer Reviewed
• [Journal Article] Multiple rheumatoid bursal cysts with invasion into the calcaneus. (2009)
  • Author(s): Kawamura K, Momohara S.
  • Journal Title: J Clin Rheumatol. 15(8) Pages: 430
  • Peer Reviewed
• [Journal Article] Clinical image : adductor muscle strain in an elderly patient with suspected femoral neck fracture. (2009)
  • Author(s): Kawakami K, Ikari K, Yano K, Momohara S
  • Journal Title: Arthritis Rheum. 60(11) Pages: 3446
  • Peer Reviewed
• [Journal Article] Complications and features after joint surgery in rheumatoid arthritis patients treated with tumour necrosis factor-alpha blockers : perioperative interruption of tumour necrosis factor-alpha blockers decreases complications? (2009)
  • Author(s): Kawakami K, Ikari K, Kawamura K, Tsukahara S, Iwamoto T, Yano K, Sakuma Y, Tokita A, Momohara S
  • Journal Title: Rheumatology (Oxford). 49(2) Pages: 341-7
  • Peer Reviewed
• [Journal Article] Multiple extensor tendon ruptures caused by tophaceous gout. (2009)
  • Author(s): Iwamoto T, Toki H, Ikari K, Yamanaka H, Momohara S
  • Journal Title: Mod Rheumatol. 20(2) Pages: 210-2
  • Peer Reviewed
• [Journal Article] Associated factors for falls and fear of falling in Japanese patients with rheumatoid arthritis. (2009)
  • Author(s): Furuya T, Yamagiwa K, Ikai T, Inoue E, Taniguchi A, Momohara S, Yamanaka H
  • Journal Title: Clin Rheumatol. 28(11) Pages: 1325-30
  • Peer Reviewed
• [Journal Article] A1330V polymorphism of low-density lipoprotein receptor-related protein 5 gene and self-reported incident fractures in Japanese female patients with rheumatoid arthritis. (2009)
  • Author(s): Furuya T, Urano T, Ikari K, Kotake S, Inoue S, Hara M, Momohara S, Kamatani N, Yamanaka H.
  • Journal Title: Mod Rheumatol. 19(2) Pages: 140-6
  • Peer Reviewed
• [Journal Article] Effect of matrix metalloproteinase-3 functional SNP on serum matrix metalloproteinase-3 level and outcome measures in Japanese RA patients. (2008)
  • Author(s): Tsukahara S, Shinozaki M, Ikari K, Mochizuki T, Inoue E, Tomatsu T, Hara M, Yamanaka H, Kamatani N, Momohara S
  • Journal Title: Rheumatology (Oxford). 47(1) Pages: 41-4
  • Peer Reviewed
• [Journal Article] CTLA-4 CT60 polymorphism is not an independent genetic risk marker of rheumatoid arthritis in a Japanese population (2008)
  • Author(s): Tsukahara S, Iwamoto T, Ikari K, Inoue E, Tomatsu T, Hara M, Yamanaka H, Kamatani N, Momohara S
  • Journal Title: Ann Rheum Dis. 67(3) Pages: 428-9
  • Peer Reviewed
• [Journal Article] A polymorphism in the gene encoding the Fcgamma IIIA receptor is a possible genetic marker to predict the primary response to infliximab in Japanese patients with rheumatoid arthritis. (2008)
  • Author(s): Tsukahara S, Ikari K, Sato E, Yamanaka H, Hara M, Tomatsu T, Momohara S, Kamatani N
  • Journal Title: Ann Rheum Dis. 67(12) Pages: 1791-2
  • Peer Reviewed
• [Journal Article] Iliopsoas bursitis-associated femoral neuropathy exacerbated after internal fixation of an intertrochanteric hip fracture in rheumatoid arthritis : a case report. (2008)
  • Author(s): Tokita A, Ikari K, Tsukahara S, Toki H, Miyawaki M, Mochizuki T, Kawamura K, Tomatsu T, Momohara S
  • Journal Title: Mod Rheumatol. 18(4) Pages: 394-8
  • Peer Reviewed
• [Journal Article] Infusion reaction to infliximab in a patient with rheumatoid arthritis after discontinuation over 1 year and readministration. (2008)
  • Author(s): Toki H, Momohara S, Tsukahara S, Ikari K
  • Journal Title: J Rheumatol. 35(9) Pages: 1896-7
  • Peer Reviewed
• [Journal Article] Return of infliximab efficacy after total knee arthroplasty in a patient with rheumatoid arthritis. (2008)
  • Author(s): Toki H, Momohara S, Ikari K, Kawamura K, Tsukahara S, Mochizuki T, Sato E, Yamanaka H
  • Journal Title: Clin Rheumatol. 27(4) Pages: 549-50
  • Peer Reviewed
• [Journal Article] Serum amyloid A activates nuclear factor-kappaB in rheumatoid synovial fibroblasts through binding to receptor of advanced glycation end-products. (2008)
  • Author(s): Okamoto H, Katagiri Y, Kiire A, Momohara S, Kamatani N
  • Journal Title: J Rheumatol. 35(5) Pages: 752-6
  • Peer Reviewed
• [Journal Article] Lack of association between PADI4 and functional severity in Japanese rheumatoid arthritis patients. (2008)
  • Author(s): Nishimoto K, Ikari K, Mochizuki T, Tomatsu T, Toyama Y, Hara M, Yamanaka H, Kamatani N, Momohara S
  • Journal Title: Ann Rheum Dis. 67(3) Pages: 431-2
  • Peer Reviewed
• [Journal Article] Factors affecting anteroposterior instability following cruciate-retaining total knee arthroplasty in patients with rheumatoid arthritis. (2008)
  • Author(s): Niki Y, Mochizuki T, Momohara S, Saito S, Matsumoto H, Tomatsu T
  • Journal Title: Knee. 15(1) Pages: 26-30
  • Peer Reviewed
• [Journal Article] Chondrocyte of rheumatoid arthritis serve as a source of intra-articular acute-phase serum amyloid A protein. (2008)
  • Author(s): Momohara S, Okamoto H, Yamanaka H
  • Journal Title: Clin Chim Acta. 398(1-2) Pages: 155-6
• [Journal Article] Risk factors for wrist surgery in rheumatoid arthritis. (2008)
  • Author(s): Momohara S, Inoue E, Ikari K, Tsukahara S, Kawamura K, Toki H, Hara M, Kamatani N, Yamanaka H, Tomatsu T.
  • Journal Title: Clin Rheumatol. 27(11) Pages: 1387-91
  • Peer Reviewed
• [Journal Article] A role for the aryl hydrocarbon receptor and the dioxin TCDD in rheumatoid arthritis. (2008)
  • Author(s): Kobayashi S, Okamoto H, Iwamoto T, Toyama Y, Tomatsu T, Yamanaka H, Momohara S
  • Journal Title: Rheumatology (Oxford). 47(9) Pages: 1317-22
  • Peer Reviewed
• [Journal Article] Molecular aspects of rheumatoid arthritis : role of environmental factors. (2008)
  • Author(s): Kobayashi S, Momohara S, Kamatani N, Okamoto H
  • Journal Title: FEBS J. 275(18) Pages: 4456-62
  • Peer Reviewed
• [Journal Article] Association of STAT4 with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Japanese population. (2008)
  • Author(s): Kobayashi S, Ikari K, Kaneko H, Kochi Y, Yamamoto K, Shimane K, Nakamura Y, Toyama Y, Mochizuki T, Tsukahara S, Kawaguchi Y, Terai C, Hara M, Tomatsu T, Yamanaka H, Horiuchi T, Tao K, Yasutomo K, Hamada D, Yasui N, Inoue H, Itakura M, Okamoto H, Kamatani N, Momohara S.
  • Journal Title: Arthritis Rheum. 58(7) Pages: 1940-6
  • Peer Reviewed
• [Journal Article] Molecular aspects of rheumatoid arthritis : chemokines in the joints of patients. (2008)
  • Author(s): Iwamoto T, Okamoto H, Toyama Y, Momohara S
  • Journal Title: FEBS J. 275(18) Pages: 4448-55
  • Peer Reviewed
• [Remarks] ホームページ等
  • URL: http://www.twmu.ac.jp/IOR/JointSurgery/