2010 Fiscal Year Final Research Report
Mechanisms of functional modification of ion channel by anesthetics
| Project/Area Number |
20591802
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
SETO Tomoyoshi Shiga University of Medical Science, 医学部, 講師 (10335177)
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| Co-Investigator(Kenkyū-buntansha) |
OZAKI Masayuki 滋賀医科大学, 医学部, 助教 (50389459)
KAWAHITO Michio 滋賀医科大学, 医学部, 非常勤講師 (20378467)
NOSAKA Shuichi 滋賀医科大学, 医学部, 教授 (80237833)
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| Project Period (FY) |
2008 – 2010
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| Keywords | KcsA / 平面膜法 / ドッキングシミュレーション / 麻酔薬結合部位 / 麻酔メカニズム |
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| Research Abstract |
Anesthetics ( Xe, Kr, Ar ) bound to (A) lipid binding site, (B) pre-filter water site, (C) inter-helix site, (D) C-terminal domain, and (E) gate. Xenon distributed to lipid binding site. This binding site is in between protein-water and lipid-water interfaces. Pre-filter water site is structured water site which involves dehydration process of potassium ion. These xenon binding site are suggested to have important contributions to modification of KcsA function.
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