2010 Fiscal Year Final Research Report
Elucidation of the mechanism involved in ischemic preconditioning using siRNA technology
| Project/Area Number |
20591803
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HAYASHI Yukio 大阪大学, 医学系研究科, 准教授 (60294063)
SHIBUTA Satoshi 大阪大学, 医学系研究科, 助教 (20324767)
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| Project Period (FY) |
2008 – 2010
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| Keywords | ラット / プレコンディショニング / 脳虚血 / 心筋虚血 / 脳死 / 心機能 |
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| Research Abstract |
We tried to elucidate the role of hypoxia inducible factor (HIF)-1α in ischemic preconditioning by regulating HIF-1α gene expression using siRNA technology, but the effect of the siRNA did not reach statistical significance. During the experiment, we found that brain damage significantly affected cardiac function, and that the mitochondrial ATP sensitive potassium channel, which is known to be another important component of preconditioning, played an important role in the phenomenon.
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