2010 Fiscal Year Final Research Report
The Research of Intracellular Energy-Related Metabolic Regulatory Enzymes on Delayed Neuronal Cell Death
| Project/Area Number |
20591806
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Yamaguchi University |
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Principal Investigator |
FUKUDA Shiro Yamaguchi University, 大学院・医学系研究科, 講師 (70322245)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Mishiya 山口大学, 大学院・医学系研究科, 教授 (60243664)
ISHIDA Kazuyoshi 山口大学, 医学部付属病院, 講師 (80314813)
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| Project Period (FY) |
2008 – 2010
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| Keywords | AMP-activated Protein Kinase / 脳虚血 / ラット / AICAR / compound C |
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| Research Abstract |
The tendency of increasing in p-AMPKα2 and p-AMPKβ1 was observed in the brain samples 60 minutes after decapitation of rats. This result suggested that AMPK was activated by neuronal ischemia. Infarction volumes in focal ischemia with rat model were decreased by AICAR, which is one of the activators of AMPK. However, AICAR exacerbated neuronal damage in gerbil forebrain ischemia, and the same exacerbation was observed in the administration of Compound C, one of the AMPK inhibitors.
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