2010 Fiscal Year Final Research Report
Gene therapy for treatment of pulmonary hypertension using plasmid vector
| Project/Area Number |
20591810
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Yokohama City University |
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Principal Investigator |
MIZUNO Yusuke 横浜市立大学, 医学部・麻酔科, 講師 (80433192)
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| Co-Investigator(Kenkyū-buntansha) |
BABA Yasuko 横浜市立大学, 市民総合医療センター, 講師 (80453041)
KAWAKAMI Hiromasa 横浜市立大学, 医学部麻酔科, 助教 (90407958)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 肺高血圧 / 遺伝子治療 / PACAP / HO-1 / プラスミドベクター / レンチウイルスベクター |
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| Research Abstract |
We found decreased expression of neuropeptide VIP, PACAP and decreased expression of their receptors in lung of monocrotaline-induced pulmonary hypertension in rat. It was assumed that the receptor might be induced to compensate for the decrease of VIP and PACAP. Thus, we hypothesized that induction of PACAP in lung could improve pulmonary hypertension. To examine the hypethesis, we created PACAP encoding plasmid and lentivirus vectors and examined the way to introduce them to the lung.
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